1 Result for "

Ro 67-4853

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Ro 67-4853" in MCE Product Catalog:

Cat. No.: HY-107506
CAS No.: 302841-89-0
Purity:  99.90%
Target:  

mGluR

Research Areas:  

Neurological Disease

Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation .
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