5 Results for "

SGD1882

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "SGD1882" in MCE Product Catalog:

Cat. No.: HY-101127
CAS No.: 1222490-34-7
Purity:  98.45%
Synonyms: PBD dimer
Target:  

ADC Payloads

Research Areas:  

Cancer

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
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Cat. No.: HY-P99238
CAS No.: 2095467-30-2

Target:  

ADC Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
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Cat. No.: HY-126678
CAS No.: 3026416-27-0
Synonyms: Dimethyl-PBD dimer
Target:  

ADC Payloads

Research Areas:  

Cancer

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication .
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Cat. No.: HY-P99881
CAS No.: 2095467-44-8
Synonyms: ABBV 176

Research Areas:  

Cancer

Rolinsatamab talirine (ABBV 176) is a prolactin receptor (PRLR)-targeting antibody-drug conjugate (ADC), compoused of Rolinsatamab (HY-P99238) and SGD-1882 (HY-101127). Rolinsatamab talirine binds to PRLR to deliver a cytotoxin to tumor cells. Rolinsatamab talirine induces DNA damage, and exhibits cytotoxicity against multiple breast tumor models, including triple negative and low PRLR-expressing models. Rolinsatamab talirine demonstrates enhanced anti-tumor activity in several breast cancer models. Rolinsatamab talirine can be used for the research of breast cancer, hepatocellular carcinoma, ovarian cancer, endometrial cancer, prostate cancer, colorectal cancer, adrenocortical carcinoma, and solid tumors .
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Cat. No.: HY-148760
CAS No.: 2057431-94-2
Research Areas:  

Others

SGD-1882-Dap-Val is an intermediate compound. SGD-1882-Dap-Val can be used in the synthesis of antibody-drug conjugates (ADCs) .
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