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Spermidine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amino Acid Derivatives (1) Bacterial (1) Biochemical Assay Reagents (7) Caspase (4) CDK (1) DNA/RNA Synthesis (1) Drug Derivative (2) Endogenous Metabolite (8) HCV (1) Isotope-Labeled Compounds (3) mAChR (1) Microtubule/Tubulin (1) mTOR (3) Nucleoside Antimetabolite/Analog (1) PAK (1) Parasite (4) Reference Standards (3) Topoisomerase (1)
By Research Areas:	Cancer (7) Infection (5) Inflammation/Immunology (1) Metabolic Disease (10)
Click Chemistry:	Alkynes (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1776

*Spermidine* 15+ Cited Publications	Endogenous Metabolite	Metabolic Disease
Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-B1776A

Spermidine hydrochloride 15+ Cited Publications	Endogenous Metabolite	Metabolic Disease
Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-B1776R

Spermidine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Spermidine (Standard) is the analytical standard of Spermidine. This product is intended for research and analytical applications. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-13610A

N1,N11-Diethylnorspermine tetrahydrochloride 4 Publications Verification Diethylnorspermine tetrahydrochloride; DENSPM tetrahydrochloride; BENSPM tetrahydrochloride	Caspase mTOR	Cancer
N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H₂O₂ production .

HY-B1776AS1

Spermidine-13C4 hydrochloride 1 Publications Verification	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Spermidine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-B1776S

Spermidine-d6 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Spermidine-d₆ is the deuterium labeled Spermidine . Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-W709575

Spermidine-d6 trihydrochloride 1 Publications Verification	Isotope-Labeled Compounds	Others
Spermidine-d6 trihydrochloride is the deuterium labeled Spermidine-d6 (trihydrochloride) (HY-W709575) .

HY-B1776AS

Spermidine-d8 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Spermidine-d₈ (hydrochloride)e is the deuterium labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-N12302

Scotanamine D N1-Dihydrocaffeoyl, N10-caffeoyl Spermidine	mAChR	Others
Scotanamine D (N1-Dihydrocaffeoyl, N10-caffeoyl spermidine) is a spermidine alkaloid. It can be isolated from S. tangutica. Scotanamine D potently and selectively inhibits the activity of the M1 muscarinic acetylcholine receptor, with an IC₅₀ of 32 nM. It can be used in studies related to Parkinson's disease .

HY-148433

SpdSyn binder-1	Parasite	Infection Inflammation/Immunology
SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria .

HY-114292A

(E)-tri-Pcoumaroylspermidine	Others	Others
(E)-tri-Pcoumaroylspermidine is a spermidine compound, that can be found in the florets of Carthamus tinctorius L .

HY-170757A

Spermidine-alkyne trihydrochloride	Biochemical Assay Reagents	Others
Spermidine-alkyne trihydrochloride is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne trihydrochloride is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .

HY-N11086

Tris(dihydrocaffeoyl)spermidine	Others	Metabolic Disease
Tris(dihydrocaffeoyl)spermidine is an active compound. Tris(dihydrocaffeoyl)spermidine can be isolated from potato (Solanum tuberosum) tubers. Tris(dihydrocaffeoyl)spermidine can be used for the research of metabolism .

HY-126171

Hypusine	Endogenous Metabolite	Others
Hypusine is a natural amino acid. The post-translational synthesis of hypusine is mainly catalyzed by deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) .

HY-42222

N1,N5-Bis-boc-spermidine	Biochemical Assay Reagents	Others
N1,N5-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W099540

OES2-0017	Bacterial	Infection
OES2-0017 shows potent synergy with polyamines and growth-inhibitory effects at the low micromolar range. OES2-0017 inhibits spermine/spermidine acetyltransferase (SpeG) (IC₅₀: 34.82 μM ) and other polyamine detoxification enzymes in low concentrations, perturbed the bacterial membrane in higher concentrations .

HY-P4757

*N1-Glutathionyl-spermidine* disulfide**	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

HY-178174

MGB4	DNA/RNA Synthesis Topoisomerase	Cancer
MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A). MGB4 can be used for the research of cancer, such as Prostate cancer .

HY-170757

Spermidine-alkyne	Biochemical Assay Reagents	Others
Spermidine-alkyne is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .

HY-B1776AR

Spermidine hydrochloride (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Spermidine (hydrochloride) (Standard) is the analytical standard of Spermidine (hydrochloride). This product is intended for research and analytical applications. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-13610B

N1,N11-Diethylnorspermine hydrobromide	Caspase	Cancer
N1,N11-Diethylnorspermine hydrobromide is a potent anticancer agent. N1,N11-Diethylnorspermine hydrobromide is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine hydrobromide induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine hydrobromide kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .

HY-13610

N1,N11-Diethylnorspermine Diethylnorspermine; BENSPM; DENSPM; BE-333	Caspase mTOR	Cancer
N1,N11-Diethylnorspermine is a synthetic analog of the naturally occurring polyamine spermine, can induce polyamine depletion and inhibit tumor cell growth. N1,N11-Diethylnorspermine activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H₂O₂ production .

HY-N3218

N1,N10-Bis(p-coumaroyl)spermidine	Others	Others
N1,N10-Bis(p-coumaroyl)spermidine is a phenylpropanoid that can be isolated from Fagales pollen .

HY-42213

N1,N4-Bis-Boc-spermidine	Biochemical Assay Reagents	Others
N1,N4-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-151148

Trypanothione synthetase-IN-1	Parasite	Infection
Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC₅₀ of 14.8 μM when triamine spermidine is as polyamine S .

HY-151150

Trypanothione synthetase-IN-2	Parasite	Infection
Trypanothione synthetase-IN-2 (Compound 3) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC₅₀ of 5.4 μM when triamine spermidine is as polyamine S .

HY-W190917

N1, N4-Bisazidospermine bistosylate	Biochemical Assay Reagents	Others
N1, N4-Bisazidospermine bistosylate is a spermine linker containing two azide groups. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.

HY-122039

Hypusine dihydrochloride	Amino Acid Derivatives	Others
Hypusine dihydrochloride is a natural amino acid found only in the eukaryotic translation initiation factor 5A (eIF-5A). Hypusine is formed by the transfer of the butylamine portion from spermidine to the ϵ-amino group of a specific lysine residue of eIF-5A precursor and by the hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety .

HY-W190905

N4,N9-di-Boc-spermine	Biochemical Assay Reagents	Others
N4, N9-di-Boc-spermine is a spermine linker containing two a Boc-protected amino groups and two amine groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.

HY-121989

cis-Trismethoxy resveratrol (Z)-3,5,4'-Trimethoxystilbene	Microtubule/Tubulin HCV CDK Akt PAK	Infection Metabolic Disease Cancer
cis-Trismethoxy resveratrol ((Z)-3,5,4'-Trimethoxystilbene) is an anti-HCV agent and Tubulin inhibitor, with an IC₅₀ of 4 μM against Tubulin. cis-Trismethoxy resveratrol induces G2/M phase cell cycle arrest, reduces DCLK1, decreases CDK1 levels, blocks phosphorylation of Akt Ser ⁴⁷³, and induces the expression of p21 ^Cip1/Waf1. cis-Trismethoxy resveratrol exhibits anti-tumor and hepatoprotective activities. cis-Trismethoxy resveratrol can be used in studies related to colon adenocarcinoma, hepatocellular carcinoma, hepatitis C, and liver injury .

HY-13610AR

N1,N11-Diethylnorspermine tetrahydrochloride (Standard) Diethylnorspermine tetrahydrochloride (Standard); DENSPM tetrahydrochloride (Standard); BENSPM tetrahydrochloride (Standard)	Caspase mTOR Reference Standards	Cancer
N1,N11-Diethylnorspermine (tetrahydrochloride) (Standard) is the analytical standard of N1,N11-Diethylnorspermine (tetrahydrochloride). This product is intended for research and analytical applications. N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .

HY-N19636

N1,N8-Bis(dihydrocaffeoyl) spermidine	Others	Others
N1,N8-Bis(dihydrocaffeoyl) spermidine (Compound B) is dihydrocaffeoyl polyamine found in Solanum tuberosum .

HY-183624

Trimer44NMe	Others	Cancer
Trimer44NMe is a polyamine transport inhibitor (PTI). Trimer44NMe inhibits the polyamine transport of putrescine (Put), spermidine (Spd), and spermine (Spm). Trimer44NMe can be used for research of Pancreatic ductal adenocarcinoma (PDAC) .

HY-N18105

(-)-(S)-Celacinnine	Drug Derivative	Others
(-)-(S)-Celacinnine (compound 1) is a 13-membered monocyclic spermidine alkaloid with the (S)-configuration.(-)-(S)-Celacinnine can be found in Maytenus arbutifolia, Tripterygium wilfordii, Maytenus serrata, Maytenus heterophylla subsp. heterophylla, and Pleurostylia africana, all from the Celastraceae plant family .

HY-180772

Bis(glutathionyl)spermine	Nucleoside Antimetabolite/Analog	Metabolic Disease
Bis(glutathionyl)spermine is a glutathione-spermidine conjugate .

HY-N12302A

(E/Z)-Scotanamine D (E/Z)-N1-Dihydrocaffeoyl, N10-caffeoyl Spermidine	Drug Derivative	Others
(E/Z)-Scotanamine D is a hydroxycinnamic acid amide found in the roots of Scopolia tangutica. (E/Z)-Scotanamine D is inactive against μ-, δ-, and κ-opioid receptors .

HY-W190953

N1,N12-Di-Boc-spermine	Biochemical Assay Reagents	Others
N1,N12-Di-boc-spermine is a spermine linker containing two a Boc-protected amino groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.

*N1-Glutathionyl-spermidine* disulfide**	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1776

*Spermidine* 15+ Cited Publications	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-B1776A

Spermidine hydrochloride 15+ Cited Publications	Natural Products other families Animals Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-B1776R

Spermidine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Spermidine (Standard) is the analytical standard of Spermidine. This product is intended for research and analytical applications. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-N12302

Scotanamine D N1-Dihydrocaffeoyl, N10-caffeoyl Spermidine	Structural Classification Phenols Polyphenols Lycium ruthenicum Murray Solanaceae Plants Source Classification	mAChR
Scotanamine D (N1-Dihydrocaffeoyl, N10-caffeoyl spermidine) is a spermidine alkaloid. It can be isolated from S. tangutica. Scotanamine D potently and selectively inhibits the activity of the M1 muscarinic acetylcholine receptor, with an IC₅₀ of 32 nM. It can be used in studies related to Parkinson's disease .

HY-114292A

(E)-tri-Pcoumaroylspermidine	Carthamus tinctorius L. Phenols Polyphenols Plants Compositae Source Classification	Others
(E)-tri-Pcoumaroylspermidine is a spermidine compound, that can be found in the florets of Carthamus tinctorius L .

HY-N11086

Tris(dihydrocaffeoyl)spermidine	Natural Products Phenols Plants Solanaceae Solanum phureja Juz. & Bukasov Source Classification	Others
Tris(dihydrocaffeoyl)spermidine is an active compound. Tris(dihydrocaffeoyl)spermidine can be isolated from potato (Solanum tuberosum) tubers. Tris(dihydrocaffeoyl)spermidine can be used for the research of metabolism .

HY-B1776AR

Spermidine hydrochloride (Standard)	Structural Classification Natural Products other families Animals Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Spermidine (hydrochloride) (Standard) is the analytical standard of Spermidine (hydrochloride). This product is intended for research and analytical applications. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-N3218

N1,N10-Bis(p-coumaroyl)spermidine	Phenols Polyphenols Plants Papaveraceae Source Classification	Others
N1,N10-Bis(p-coumaroyl)spermidine is a phenylpropanoid that can be isolated from Fagales pollen .

HY-N19636

N1,N8-Bis(dihydrocaffeoyl) spermidine	Structural Classification Solanum tuberosum L. Phenols Polyphenols Solanaceae Plants Source Classification	Others
N1,N8-Bis(dihydrocaffeoyl) spermidine (Compound B) is dihydrocaffeoyl polyamine found in Solanum tuberosum .

HY-N18105

(-)-(S)-Celacinnine	Structural Classification Alkaloids Other Alkaloids Celastraceae Gymnosporia arbutifolia (Hochst. ex A.Rich.) Loes. Plants Source Classification	Drug Derivative
(-)-(S)-Celacinnine (compound 1) is a 13-membered monocyclic spermidine alkaloid with the (S)-configuration.(-)-(S)-Celacinnine can be found in Maytenus arbutifolia, Tripterygium wilfordii, Maytenus serrata, Maytenus heterophylla subsp. heterophylla, and Pleurostylia africana, all from the Celastraceae plant family .

HY-180772

Bis(glutathionyl)spermine	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
Bis(glutathionyl)spermine is a glutathione-spermidine conjugate .

HY-N12302A

(E/Z)-Scotanamine D (E/Z)-N1-Dihydrocaffeoyl, N10-caffeoyl Spermidine	Structural Classification Alkaloids Other Alkaloids Anisodus tanguticus (Maxinowicz) Pascher Solanaceae Plants Source Classification	Drug Derivative
(E/Z)-Scotanamine D is a hydroxycinnamic acid amide found in the roots of Scopolia tangutica. (E/Z)-Scotanamine D is inactive against μ-, δ-, and κ-opioid receptors .

Cat. No.	Product Name	Chemical Structure

HY-B1776AS1

Spermidine-13C4 hydrochloride 1 Publications Verification
Spermidine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-B1776S

Spermidine-d6 1 Publications Verification
Spermidine-d₆ is the deuterium labeled Spermidine . Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-W709575

Spermidine-d6 trihydrochloride 1 Publications Verification
Spermidine-d6 trihydrochloride is the deuterium labeled Spermidine-d6 (trihydrochloride) (HY-W709575) .

HY-B1776AS

Spermidine-d8 hydrochloride
Spermidine-d₈ (hydrochloride)e is the deuterium labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

Cat. No.	Product Name		Classification

HY-170757

Spermidine-alkyne		Alkynes
Spermidine-alkyne is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .

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Spermidine

Inhibitors & Agonists

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Isotope-Labeled Compounds

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