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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
Spermidine
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "Spermidine" in MCE Product Catalog:
20
Category:
Human Gut Microbiota Metabolites Natural Products Microorganisms Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields
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20
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Natural Products other families Animals Metabolic Disease Plants Endogenous metabolite Disease Research Fields
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6
6 Cited Publications
Synonyms: Diethylnorspermine tetrahydrochloride; DENSPM tetrahydrochloride; BENSPM tetrahydrochloride
N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .
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1
1 Cited Publications
Cat. No.: HY-B1776AS1
CAS No.: 1313734-84-7
1
1 Cited Publications
Cat. No.: HY-B1776S
CAS No.: 2514812-10-1
1
1 Cited Publications
Cat. No.: HY-W709575
Cat. No.: HY-B1776AS
CAS No.: 1173019-26-5
Cat. No.: HY-N12302
CAS No.: 1698873-84-5
Synonyms: N1-Dihydrocaffeoyl, N10-caffeoyl Spermidine
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SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria .
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Cat. No.: HY-170757A
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Spermidine-alkyne trihydrochloride is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne trihydrochloride is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .
Cat. No.: HY-N11086
CAS No.: 859341-34-7
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Cat. No.: HY-126171
CAS No.: 34994-11-1
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Hypusine is a natural amino acid. The post-translational synthesis of hypusine is mainly catalyzed by deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) .
Cat. No.: HY-42222
CAS No.: 68076-39-1
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N1,N5-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Cat. No.: HY-W099540
CAS No.: 5538-95-4
OES2-0017 shows potent synergy with polyamines and growth-inhibitory effects at the low micromolar range. OES2-0017 inhibits spermine/spermidine acetyltransferase (SpeG) (IC50: 34.82 μM ) and other polyamine detoxification enzymes in low concentrations, perturbed the bacterial membrane in higher concentrations .
Cat. No.: HY-P4757
CAS No.: 108081-77-2
Cat. No.: HY-178174
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MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A). MGB4 can be used for the research of cancer, such as Prostate cancer .
Cat. No.: HY-170757
CAS No.: 1627941-31-4
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Spermidine-alkyne is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .
Cat. No.: HY-B1776AR
CAS No.: 334-50-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
