1698873-84-5
1698873-84-5
Chemical Structure
Scotanamine D
Synonym(s): N1-Dihydrocaffeoyl, N10-caffeoyl spermidine
- CAS No.: 1698873-84-5
- Formula:C25H33N3O6
- Molecular Weight:471.55
InChIKey: UKDQTQBQRCLXJK-YRNVUSSQSA-N
SMILES: OC(C=C1/C=C/C(NCCCNCCCCNC(CCC2=CC(O)=C(C=C2)O)=O)=O)=C(C=C1)O
Biological Activity: Scotanamine D (N1-Dihydrocaffeoyl, N10-caffeoyl spermidine) is a spermidine alkaloid. It can be isolated from S. tangutica. Scotanamine D potently and selectively inhibits the activity of the M1 muscarinic acetylcholine receptor, with an IC50 of 32 nM. It can be used in studies related to Parkinson's disease[1][2].
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Scotanamine D | Scotanamine D (N1-Dihydrocaffeoyl, N10-caffeoyl spermidine) is a spermidine alkaloid. It can be isolated from S. tangutica. Scotanamine D potently and selectively inhibits the activity of the M1 muscarinic acetylcholine receptor, with an IC50 of 32 nM. It can be used in studies related to Parkinson's disease. | |||||||||||||||||||||
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References
- [1]. Zhang Y, et al. Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro. Fitoterapia. 2016;108:9-12. [Content Brief]
- [2]. Ji J, et al. Synthesis of N1-caffeoyl-N10-dihydrocaffeoylspermidine (Scotanamine D)[J]. Letters in Organic Chemistry, 2024, 21(8): 720-726.
Keywords
