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Results for "

TDP1

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119372
    TDP1 Inhibitor-1

    		Phosphodiesterase (PDE) Cancer
    TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM. TDP1 Inhibitor-1 shows cytotoxicity against multiple cancer cells. TDP1 Inhibitor-1 can be used for the research of cancer, such as breast cancer [1].
    TDP1 Inhibitor-1
  • HY-110137
    Furamidine dihydrochloride
    3 Publications Verification

    DB75 dihydrochloride; NSC 305831 dihydrochloride

    		 Histone Methyltransferase Phosphodiesterase (PDE) Parasite Infection Inflammation/Immunology Cancer
    Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent [1] .
    Furamidine dihydrochloride
  • HY-157886
    TDP1 Inhibitor-3

    		Phosphodiesterase (PDE) Cancer
    TDP1 Inhibitor-3 (Compound 4E) is a (TDP1) inhibitor with an IC50 value of 0.63 μM [1].
    TDP1 Inhibitor-3
  • HY-161853
    TX-2552

    		Phosphodiesterase (PDE) Others
    TX-2552 is an orally active tyrosine DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 value of 0.62 μM. TX-2552 can enhance the clastogenic activity of Topotecan (HY-13768) in mouse bone marrow cells, as well as the anti-tumor effect of Topotecan (HY-13768) in Krebs-2 ascites tumor mice [1] .
    TX-2552
  • HY-147750
    TDP1 Inhibitor-2

    		Phosphodiesterase (PDE) Neurological Disease Cancer
    TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM [1].
    TDP1 Inhibitor-2
  • HY-W177546
    CD00509

    		Phosphodiesterase (PDE) Apoptosis Caspase DNA/RNA Synthesis Cancer
    CD00509 is a tyrosyl-DNA phosphodiesterase (PDE) Tdp1 inhibitor with an IC50 of 0.71 μM. CD00509 increases DNA damage and promotes apoptosis of MCF-7 cells. CD00509 can sensitize breast cancer cells and wild-type murine embryonic fibroblasts (MEFs) to Camptothecin (CPT) (HY-16560). CD00509 can be used for the study of cancers such as breast cancer [1] .
    CD00509
  • HY-110137A
    Furamidine

    DB75; NSC 305831

    		 Histone Methyltransferase Phosphodiesterase (PDE) Parasite Infection Inflammation/Immunology Cancer
    Furamidine (DB75) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent [1] .
    Furamidine
  • HY-RS17650
    Tdp1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tdp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tdp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tdp1 Mouse Pre-designed siRNA Set A
    Tdp1 Mouse Pre-designed siRNA Set A
  • HY-RS14332
    TDP1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TDP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TDP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TDP1 Human Pre-designed siRNA Set A
    TDP1 Human Pre-designed siRNA Set A
  • HY-175779
    TDP1-IN-4

    		Phosphodiesterase (PDE) Cancer
    TDP1-IN-4 (Compound 33) is a Tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 0.90  μM. TDP1-IN-4 has a strong synergistic effect with Camptothecin (HY-16560) in SK-Mel-2 cells, but not in cancer cells (A549, HCT-116 and MCF-7 cells) and non-cancerous Ges-1 cells. TDP1-IN-4 can be used for cancer chemotherapy and radiotherapy research [1].
    TDP1-IN-4
  • HY-RS24110
    Tdp1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tdp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tdp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tdp1 Rat Pre-designed siRNA Set A
    Tdp1 Rat Pre-designed siRNA Set A
  • HY-124486
    NSC-88915

    		Phosphodiesterase (PDE) Others
    NSC-88915 is an inhibitor of Tdp1 with an IC50 of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative [1] .
    NSC-88915
  • HY-176409
    Phosphodiesterase-IN-4

    		Phosphodiesterase (PDE) Cancer
    Phosphodiesterase-IN-4 (compound 18) is a potent Tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor. Phosphodiesterase-IN-4 inhibits colorectal cancer cells with an IC50 of 6.9 μM [1].
    Phosphodiesterase-IN-4
  • HY-183546
    TDP1-IN-6

    		Phosphodiesterase (PDE) DNA/RNA Synthesis Apoptosis Ferroptosis Cancer
    TDP1-IN-6 (Compound 16b) is a TDP1 inhibitor with an IC50 of 1.52 μM. Combination of TDP1-IN-6 with Topotecan (HY-13768) enhances DNA damage, induces Apoptosis, triggers S-phase cell cycle arrest, and promotes Ferroptosis. TDP1-IN-6 can be used for the research of cervical cancer [1].
    TDP1-IN-6
  • HY-183334
    TDP1-IN-5

    		Phosphodiesterase (PDE) Reactive Oxygen Species (ROS) DNA/RNA Synthesis Apoptosis Cancer
    TDP1-IN-5 is a tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 2.2 μM. By targeting TDP1 both intracellularly and extracellularly, TDP1-IN-5 inhibits the NHEJ repair pathway, arrests the cell cycle at the G2/M phase, upregulates PIG3 to enhance ROS, and ultimately significantly potentiates ionizing radiation (IR)-induced DNA damage and apoptosis. TDP1-IN-5 can be used in the research of colorectal cancer [1].
    TDP1-IN-5
  • HY-181080
    TOP1/TDP1-IN-1

    		Topoisomerase DNA/RNA Synthesis Apoptosis Cancer
    TOP1/TDP1-IN-1 is a DNA topoisomerase 1B (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with a TDP1 IC50 of 17.8 μM. TOP1/TDP1-IN-1directly suppresses TOP1 catalytic activity without forming a DNA-TOP1 ternary complex, inhibits TDP1-mediated repair of TOP1-induced DNA damage, and exhibits low acute toxicity. TOP1/TDP1-IN-1 disrupts DNA repair pathways, induces apoptosis, suppresses clonogenic growth, and elicits antiproliferative effects in cancer cells. TOP1/TDP1-IN-1 can be used for the research of non-small cell lung cancer, cervical cancer, colon cancer [1].
    TOP1/TDP1-IN-1
  • HY-110137R
    Furamidine dihydrochloride (Standard)

    DB75 dihydrochloride (Standard); NSC 305831 dihydrochloride (Standard)

    		 Histone Methyltransferase Phosphodiesterase (PDE) Parasite Reference Standards Infection Inflammation/Immunology Cancer
    Furamidine (dihydrochloride) (Standard) is the analytical standard of Furamidine (dihydrochloride). This product is intended for research and analytical applications. Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent [1] .
    Furamidine dihydrochloride (Standard)

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