TDP1 Inhibitor-3
Based on 1 Customer Validation
TDP1 Inhibitor-3 (Compound 4E) is a (TDP1) inhibitor with an IC50 value of 0.63 μM.
For research use only. We do not sell to patients.
- Purity: 98.10%
- CAS No.: 3074962-67-4
- Formula: C33H47NO4S2
- Molecular Weight:585.86
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Metabolism/Protease Compound Library
HY-L012
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Alzheimer's Disease Compound Library
HY-L069
-
Neurodegenerative Disease-related Compound Library
HY-L086
-
Anti-Colorectal Cancer Compound Library
HY-L103
-
Metabolic Enzyme Compound Library
HY-L146
-
MCE Bioactive Compound Library
HY-L001V
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
IC50: 0.63 μM (TDP1)[1].
Chemical Information
-
CAS No. 3074962-67-4
-
Appearance Solid
-
Molecular Weight 585.86
-
Formula C33H47NO4S2
-
Color White to off-white
-
SMILES
[H][C@@]12CC[C@@]3(C[C@](CSC4=NC5=C(S4)C=CC=C5)(CC[C@@]3([C@@]1([H])C[C@@H]([C@]6([C@@]2([H])CC[C@@H]6[C@@H](CCC(OC)=O)C)C)O)C)O)[H]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (85.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7069 mL | 8.5345 mL | 17.0689 mL | 42.6723 mL |
| 5 mM | 0.3414 mL | 1.7069 mL | 3.4138 mL | 8.5345 mL | |
| 10 mM | 0.1707 mL | 0.8534 mL | 1.7069 mL | 4.2672 mL | |
| 15 mM | 0.1138 mL | 0.5690 mL | 1.1379 mL | 2.8448 mL | |
| 20 mM | 0.0853 mL | 0.4267 mL | 0.8534 mL | 2.1336 mL | |
| 25 mM | 0.0683 mL | 0.3414 mL | 0.6828 mL | 1.7069 mL | |
| 30 mM | 0.0569 mL | 0.2845 mL | 0.5690 mL | 1.4224 mL | |
| 40 mM | 0.0427 mL | 0.2134 mL | 0.4267 mL | 1.0668 mL | |
| 50 mM | 0.0341 mL | 0.1707 mL | 0.3414 mL | 0.8534 mL | |
| 60 mM | 0.0284 mL | 0.1422 mL | 0.2845 mL | 0.7112 mL | |
| 80 mM | 0.0213 mL | 0.1067 mL | 0.2134 mL | 0.5334 mL |
TDP1 Inhibitor-3 Related Classifications
HY-157886 Related Classifications
Powered by Bioz