3115524-78-9
Chemical Structure
TDP1-IN-5
- CAS No.: 3115524-78-9
- Formula:C34H45N5O5
- Molecular Weight:603.75
InChIKey: VUSRJDJRDRLWMK-UHFFFAOYSA-N
SMILES: CN(C)CCN1C(C2=CC(OC)=C(OCCCN3CCN(CCN(C)C)CC3)C=C2C4=C1C(C=C(OCO5)C5=C6)=C6C=C4)=O
Biological Activity: TDP1-IN-5 is a tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 2.2 μM. By targeting TDP1 both intracellularly and extracellularly, TDP1-IN-5 inhibits the NHEJ repair pathway, arrests the cell cycle at the G2/M phase, upregulates PIG3 to enhance ROS, and ultimately significantly potentiates ionizing radiation (IR)-induced DNA damage and apoptosis. TDP1-IN-5 can be used in the research of colorectal cancer[1].
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TDP1-IN-5 | TDP1-IN-5 is a tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 2.2 μM. By targeting TDP1 both intracellularly and extracellularly, TDP1-IN-5 inhibits the NHEJ repair pathway, arrests the cell cycle at the G2/M phase, upregulates PIG3 to enhance ROS, and ultimately significantly potentiates ionizing radiation (IR)-induced DNA damage and apoptosis. TDP1-IN-5 can be used in the research of colorectal cancer. | |||||||||||||||||||||
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