2446767-14-0
2446767-14-0
Chemical Structure
TX-2552
- CAS No.: 2446767-14-0
- Formula:C25H25FO3
- Molecular Weight:392.46
InChIKey: ZYLGAPYUNVKATB-QGOAFFKASA-N
SMILES: O=C(O1)C=C(C2=CC=C(F)C=C2)C3=C1C=C(OC/C=C(C)/CC/C=C(C)/C)C=C3
Biological Activity: TX-2552 is an orally active tyrosine DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 value of 0.62 μM. TX-2552 can enhance the clastogenic activity of Topotecan (HY-13768) in mouse bone marrow cells, as well as the anti-tumor effect of Topotecan (HY-13768) in Krebs-2 ascites tumor mice[1][2].
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TX-2552 | 99.69% | TX-2552 is an orally active tyrosine DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 value of 0.62 μM. TX-2552 can enhance the clastogenic activity of Topotecan (HY-13768) in mouse bone marrow cells, as well as the anti-tumor effect of Topotecan (HY-13768) in Krebs-2 ascites tumor mice. | ||||||||||||||||||||
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References
- [1]. Zhanataev AK, et al. Enhancement of the Clastogenic Effects of Topotecan In Vivo by Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Bull Exp Biol Med. 2024 May;177(1):30-34. [Content Brief]
- [2]. Khomenko TM, et al. Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy. Int J Mol Sci. 2019 Dec 23;21(1):126. [Content Brief]
Keywords
