TDP1 Inhibitor-1
Based on 1 Customer Validation
TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM. TDP1 Inhibitor-1 shows cytotoxicity against multiple cancer cells. TDP1 Inhibitor-1 can be used for the research of cancer, such as breast cancer.
For research use only. We do not sell to patients.
- Purity: 98.33%
- CAS No.: 2248702-80-7
- Formula: C26H26N2O5
- Molecular Weight:446.50
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Biological Activity
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TDP1 7 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
1.53 μM
Compound: 41a
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Growth inhibition of human A549 cells after 72 hrs by MTT assay
Growth inhibition of human A549 cells after 72 hrs by MTT assay
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[PMID: 30336023] |
| CCRF-CEM | GI50 |
2.63 μM
Compound: 41a
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Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay
Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay
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[PMID: 30336023] |
| DU-145 | GI50 |
4.29 μM
Compound: 41a
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Growth inhibition of human DU145 cells after 72 hrs by MTT assay
Growth inhibition of human DU145 cells after 72 hrs by MTT assay
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[PMID: 30336023] |
| HCT-116 | GI50 |
31.04 μM
Compound: 41a
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Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
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[PMID: 30336023] |
| Huh-7 | GI50 |
2.78 μM
Compound: 41a
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Growth inhibition of human HuH7 cells after 72 hrs by MTT assay
Growth inhibition of human HuH7 cells after 72 hrs by MTT assay
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[PMID: 30336023] |
TDP1 Inhibitor-1 (Compound 41a) (100 μM) exhibits TDP1 inhibition with the percentage inhibition of 92%[1].
TDP1 Inhibitor-1 shows cytotoxicity against CCRF-CEM, DU145, A549, and Huh7 cells with IC50 values of 2.63, 4.29, 1.53 and 2.78 μM[1].
TDP1 Inhibitor-1 (1.25-5 μM, 96 h) increases the cytotoxicity of Camptothecin (HY-16560) against MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:1.25, 2.5 and 5 μM, companied with Camptothecin
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Incubation Time:96 h
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Result:Almost 60% of cells were killed at 2.5 μM.
Over 90% of cells were killed at 5 μM.
Chemical Information
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CAS No. 2248702-80-7
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Appearance Solid
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Molecular Weight 446.50
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Formula C26H26N2O5
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Color Off-white to light yellow
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SMILES
COC1=C(OC)C=C(C(OCCN2CCCC2)=NC3=C4C=CC5=CC6=C(OCO6)C=C35)C4=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 3.33 mg/mL (7.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2396 mL | 11.1982 mL | 22.3964 mL | 55.9910 mL |
| 5 mM | 0.4479 mL | 2.2396 mL | 4.4793 mL | 11.1982 mL |
TDP1 Inhibitor-1 Related Classifications
HY-119372 Related Classifications
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