27430-18-8
27430-18-8
Chemical Structure
CD00509
- CAS. Nr.: 27430-18-8
- Formula:C9H6N2O3S
- Molecular Weight:222.22
IUPAC Name: 5-(furan-2-ylmethylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
InChIKey: VQRARDATQWRHGF-UHFFFAOYSA-N
SMILES: S=C1NC(=O)C(C(N1)=O)=CC2=CC=CO2
Biological Activity: CD00509 is a tyrosyl-DNA phosphodiesterase (PDE) Tdp1 inhibitor with an IC50 of 0.71 μM. CD00509 increases DNA damage and promotes apoptosis of MCF-7 cells. CD00509 can sensitize breast cancer cells and wild-type murine embryonic fibroblasts (MEFs) to Camptothecin (CPT) (HY-16560). CD00509 can be used for the study of cancers such as breast cancer[1][2][3].
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CD00509 | 98.0% | CD00509 is a tyrosyl-DNA phosphodiesterase (PDE) Tdp1 inhibitor with an IC50 of 0.71 μM. CD00509 increases DNA damage and promotes apoptosis of MCF-7 cells. CD00509 can sensitize breast cancer cells and wild-type murine embryonic fibroblasts (MEFs) to Camptothecin (CPT) (HY-16560). CD00509 can be used for the study of cancers such as breast cancer. | ||||||||||||||||||||
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References
- [1]. Laev SS, et al. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential. Bioorg Med Chem. 2016 Nov 1;24(21):5017-5027. [Content Brief]
- [2]. Dean RA,et al. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays. J Biomol Screen. 2014 Dec;19(10):1372-82. [Content Brief]
- [3]. Dean RA, et al. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays. J Biomol Screen. 2014 Dec;19(10):1372-82. [Content Brief]
