Search Result

Results for "

TNF-R

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (38) Antibiotic (1) Apoptosis (15) Aryl Hydrocarbon Receptor (1) Autophagy (1) Bcl-2 Family (1) Cannabinoid Receptor (1) Caspase (4) COX (2) Cytochrome P450 (1) Drug Derivative (1) Environmental Pollutants (1) ERK (4) Flavivirus (4) Integrin (1) Interleukin Related (6) JNK (5) Keap1-Nrf2 (2) Mitochondrial Metabolism (1) NF-κB (16) NO Synthase (2) p38 MAPK (6) Parasite (1) PROTACs (1) RANKL/RANK (3) Reference Standards (2) Ser/Thr Kinase (1) Ser/Thr Protease (4) Small Interfering RNA (siRNA) (2) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (26) Infection (5) Inflammation/Immunology (31) Metabolic Disease (4) Neurological Disease (7)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: TNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-11109

Resatorvid Maximum Cited Publications 494 Publications Verification TAK-242; CLI-095	Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC_50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .

HY-P9970

Infliximab Maximum Cited Publications 27 Publications Verification Avakine; CT-P13; SB2; TA-650	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research . The component ratio of this product is Active ingredient : Excipients = 9 : 47.

HY-110203

R-7050 25+ Cited Publications TNF-α Antagonist III	TNF Receptor	Cancer
R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

HY-160412

Balinatunfib SAR-441566; TNFα activity modulator 3	TNF Receptor	Inflammation/Immunology
Balinatunfib (SAR-441566) is an orally active inhibitor of *TNFR1* signaling. By binding to the central pocket of the soluble TNFα (sTNFα) trimer, Balinatunfib stabilizes an asymmetric conformation, blocking its binding to *TNFR1* (without affecting TNFR2) and thus inhibiting downstream pathways. Balinatunfib has anti-inflammatory activity, and can be used in the study of autoimmune diseases .

HY-B0190A

Nafamostat mesylate 15+ Cited Publications FUT-175	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall .

HY-126741

Azadirachtin 2 Publications Verification	Environmental Pollutants Parasite Caspase NF-κB Apoptosis Bcl-2 Family	Infection Inflammation/Immunology Cancer
Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting *TNFR* activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells .

HY-P9970A

*Infliximab (Anti-TNF-α)* Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .

HY-P1860

TNF-α (31-45), human 10+ Cited Publications	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology Cancer
TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-111255

SPD304 5+ Cited Publications	TNF Receptor	Cancer
SPD304 is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

HY-134471

TNF-α-IN-2 1 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
TNF-α-IN-2 is a potent and orally active inhibitor of *tumor necrosis factor alpha (TNFα), with an IC₅₀* of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis .

HY-N0481

Roburic acid 1 Publications Verification	COX TNF Receptor NO Synthase Interleukin Related NF-κB Apoptosis p38 MAPK JNK ERK Keap1-Nrf2 RANKL/RANK	Neurological Disease Inflammation/Immunology Cancer
Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a K_i of 7.066 μM against human *TNF, an IC₅₀* of 9 μM against human COX-2, and an IC₅₀ of 5 μM against ovine COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6 in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the *TNF-TNF-R1* interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases .

HY-P991049

Atrosimab ATM-001	TNF Receptor	Metabolic Disease Inflammation/Immunology
Atrosimab is an Fv-Fc1K fusion protein with an EC₅₀ value of 0.37 nM against humans. Atrosimab inhibits TNF-induced TNFR1 activation, release of IL-6 and IL-8, and cell death, and alleviates neuroinflammation. Atrosimab is applicable to research related to inflammatory diseases, neurodegenerative diseases, acute and chronic inflammation, experimental arthritis, non-alcoholic steatohepatitis, and experimental autoimmune encephalomyelitis .

HY-171658

R1-ICR-5	PROTACs Ser/Thr Kinase TNF Receptor Toll-like Receptor (TLR) NF-κB p38 MAPK	Inflammation/Immunology Cancer
R1-ICR-5 is a highly selective RIPK1 PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1, which in turn dysregulates the *TNFR1* and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB, MAPK and IFN, and simultaneously promotes RIPK3 activation and necroptosis (necroptosis). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation .

HY-P991400

GSK1995057	TNF Receptor Apoptosis Interleukin Related NF-κB JNK p38 MAPK	Inflammation/Immunology
GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to *TNFR1, blocks the binding of TNF-α* and LT-α, and does not interfere with *TNFR2* signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, *TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1* and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury .

HY-P990008

Atrosab 1 Publications Verification	TNF Receptor Apoptosis	Inflammation/Immunology
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated Apoptosis induction and IL-6 and IL-8 production. Atrosab reduces neurological deficits. Atrosab can be used for research of inflammatory disease. The recommend isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-111255A

SPD304 dihydrochloride 5+ Cited Publications	TNF Receptor	Inflammation/Immunology Cancer
SPD304 dihydrochloride is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

HY-133807

Benpyrine 3 Publications Verification	TNF Receptor	Inflammation/Immunology
Benpyrine is a highly specific and orally active *TNF-α* inhibitor with a K_D value of 82.1 μM. Benpyrine tightly binds to *TNF-α* and blocks its interaction with TNFR1, with an IC₅₀ value of 0.109 µM. Benpyrine has the potential for *TNF-α* mediated inflammatory and autoimmune disease research .

HY-P11108

RP-182	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research .

HY-P991192

BI-1808	TNF Receptor	Cancer
BI-1808 is a human IgG1 monoclonal antibody that targets *TNFR2by blocking interaction of TNFR2 with ligand TNF*-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8 ⁺ T cells .

HY-P99812

Ragifilimab 1 Publications Verification INCAGN-1876	TNF Receptor	Inflammation/Immunology Cancer
Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab binds to and activates GITR on T cells, which stimulates the immune system to enhance its anti-tumor activity. Ragifilimab can be used for advanced or metastatic solid tumors research .

HY-118922

IW927	TNF Receptor	Neurological Disease Inflammation/Immunology Cancer
IW927 is a photochemically enhanced *TNF-α-TNFR1* interaction inhibitor that blocks the binding of *TNF-α* to TNFRc1 with an IC₅₀ value of 50 nM. IW927 binds reversibly to the TNFRc1 with weak affinity (K_d = 40-100 μM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40. IW927 disrupts TNFα-induced IκB phosphorylation with an IC₅₀ value of 600 nM. IW927 can be used to develop light-independent inhibitors .

HY-P2612

WP9QY	TNF Receptor RANKL/RANK Apoptosis	Inflammation/Immunology
WP9QY is an inhibitor targeting TNFα and RANKL, which blocks the *TNFα-TNFR1* interaction and inhibits TNFα-mediated apoptosis, cytotoxicity and bone destruction. WP9QY inhibits osteoclastogenesis and promotes osteoblast differentiation, induces chondrocyte proliferation and glycosaminoglycan production, and synergizes with TGF-β3 to promote chondrogenesis. WP9QY effectively repairs full-thickness articular cartilage defects in rabbits via intra-articular injection, and inhibits methylmercury-induced reduction of NeuN-positive cells in mouse brain slices. WP9QY can be applied to the research of diseases related to methylmercury-induced neuronal death, cartilage injury, osteoarthritis and bone loss .

HY-P99149

*Anti-Mouse TNFR2 Antibody (TR75-54.7)*	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse *TNFR2* IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer .

HY-124339

JNJ525	TNF Receptor	Neurological Disease Inflammation/Immunology Cancer
JNJ525 is a TNFα inhibitor with IC₅₀ values of 1.2 μM and 1.1 μM against *TNFR1* and *TNFR2, respectively. JNJ525 forms ordered aggregates and induces quaternary structural transition of TNFα, thereby blocking the protein-protein interaction between TNF*α and its receptors. The inhibitory activity of JNJ525 is completely lost in the presence of 0.1% Triton X-100 .

HY-P1860A

TNF-α (31-45), human TFA 10+ Cited Publications	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology
TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-B0190

Nafamostat	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat has anticancer and antivirus effect. Nafamostat induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat can be used in the development of the pathological thickening of the arterial wall .

HY-B0190AR

Nafamostat mesylate (Standard) FUT-175 (Standard)	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease Reference Standards	Infection Cancer
Nafamostat (mesylate) (Standard) is the analytical standard of Nafamostat (mesylate). This product is intended for research and analytical applications. Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall .

HY-P99692

Lenercept p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1	TNF Receptor	Inflammation/Immunology
Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble *TNF-receptor* (p55) linked to the Fc portion of human IgG1 .

HY-119420

Acetoxycycloheximide	Antibiotic Apoptosis Caspase JNK p38 MAPK TNF Receptor ERK NF-κB Mitochondrial Metabolism	Inflammation/Immunology Cancer
Acetoxycycloheximide is an antibiotic with antitumor activity. Acetoxycycloheximide a protein synthesis inhibitor. Acetoxycycloheximide significantly induces activation of procaspase-3 and subsequent apoptosis mediated by the Cytochrome c from mitochondria via activation of JNK pathway. Acetoxycycloheximide triggers the downregulation of cell surface *TNF-R1* via the activation of ERK and p38 MAPK, thereby preventing activation of the NF-κB signaling pathway by TNF-α. Acetoxycycloheximide is much more toxic to female rats than to males. Acetoxycycloheximide can be used for inflammatory and immune diseases and cancers research .

HY-P99543

Tulinercept OPRX-106; PRX-106; TNFR-Fc	TNF Receptor	Cancer
Tulinercept (OPRX-106) is a recombinant TNF receptor fusion protein fused to an IgG1 Fc domain .

HY-P991195

SIM-0235 SIM1811-03	TNF Receptor	Cancer
SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits *TNFR2*, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

HY-P11214

Hydrostatin-TL1 H-TL1	TNF Receptor Integrin NF-κB ERK p38 MAPK JNK Interleukin Related	Inflammation/Immunology
Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a *TNF-α* antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research .

HY-P11108A

RP-182 acetate	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research .

HY-178053

AHR agonist 10	Aryl Hydrocarbon Receptor Cytochrome P450 Interleukin Related	Inflammation/Immunology
AHR agonist 10 is a potent AHR agonist (EC₅₀ = 2.01 nM). AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including CYP1A1 and CYP1B1. AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR dependent signaling pathways. AHR agonist 10 can be used for psoriasis research .

HY-124954

MN-25	Cannabinoid Receptor TNF Receptor	Neurological Disease Inflammation/Immunology
MN-25 (compound 4a) is an orally active indolpyridone that serves as a novel cannabinoid ligand. MN-25 has K_i of 245 nM and 11 nM for CB1 and CB2. MN-25 has CB2 agonist activity and inhibits *TNF-R* release in human peripheral blood mononuclear cells in vitro with an IC₅₀ of 33 μM. MN-25 shows efficacy in a mouse acute inflammation model at oral doses up to 50 mg/kg ^>[1].

HY-B0190B

Nafamostat hydrochloride	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall .

HY-133807B

(R)-Benpyrine	TNF Receptor	Inflammation/Immunology
(R)-Benpyrine is the isomer of Benpyrine (HY-133807), and can be used as an experimental control. Benpyrine is a highly specific and orally active *TNF-α* inhibitor with a K_D value of 82.1 μM. Benpyrine tightly binds to *TNF-α* and blocks its interaction with TNFR1, with an IC₅₀ value of 0.109 μM. Benpyrine has the potential for *TNF-α* mediated inflammatory and autoimmune disease research .

HY-RS14810

TNFRSF1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNFRSF1A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNFRSF1A Human Pre-designed siRNA Set A TNFRSF1A Human Pre-designed siRNA Set A

HY-145492

Δ7(Z)-C14-HSL N-(3-Oxo-7Z-tetradecenoyl)-L-homoserine lactone	Drug Derivative	Inflammation/Immunology
Δ7(Z)-C14-HSL (Compound 12) is an immunosuppressive agent that can inhibit the proliferation of mouse splenic cells with an IC₅₀ of 17 μM. Δ7(Z)-C14-HSL can be used for further studying its potential as a molecular mechanism in TNF-R-driven immune diseases, especially autoimmune diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes .

HY-N0481R

Roburic acid (Standard)	Reference Standards COX TNF Receptor NO Synthase Interleukin Related NF-κB Apoptosis p38 MAPK JNK ERK Keap1-Nrf2 RANKL/RANK	Inflammation/Immunology
Roburic acid (Standard) is the analytical standard of Roburic acid. This product is intended for research and analytical applications. Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a K_i of 7.066 μM against human *TNF, an IC₅₀* of 9 μM against human COX-2, and an IC₅₀ of 5 μM against ovine COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6 in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the *TNF-TNF-R1* interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases.

HY-P992399

LBL-019	TNF Receptor NF-κB	Cancer
LBL-019 is a humanized IgG1 monoclonal antibody targeting *TNFR2. LBL-019 costimulates TNFR2* and activates the NF-κB signaling pathway in an Fc crosslinking-dependent manner. LBL-019 can be used for the research of advanced malignant tumors, including hepatocellular carcinoma and melanoma. The recommended isotype control is human IgG1 kappa (HY-P99001) .

HY-182884

TNF-α-IN-29	TNF Receptor	Inflammation/Immunology
TNF-α-IN-29 is an orally active and selective *TNF-α* inhibitor, with IC₅₀ values of 123.0 nM against human targets, and a human K_d of 45.9 nM. TNF-α-IN-29 blocks TNF-α-TNFR1 protein-protein interactions and inhibits TNF-α-mediated inflammatory signaling pathways. TNF-α-IN-29 exhibits anti-inflammatory effects in a mouse model of collagen-induced arthritis and promotes articular cartilage repair. TNF-α-IN-29 can be used for the research of rheumatoid arthritis .

HY-RS17012

Tnfrsf1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf1a Mouse Pre-designed siRNA Set A Tnfrsf1a Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P1860

TNF-α (31-45), human 10+ Cited Publications	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology Cancer
TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-P11108

RP-182	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research .

HY-P2612

WP9QY	TNF Receptor RANKL/RANK Apoptosis	Inflammation/Immunology
WP9QY is an inhibitor targeting TNFα and RANKL, which blocks the *TNFα-TNFR1* interaction and inhibits TNFα-mediated apoptosis, cytotoxicity and bone destruction. WP9QY inhibits osteoclastogenesis and promotes osteoblast differentiation, induces chondrocyte proliferation and glycosaminoglycan production, and synergizes with TGF-β3 to promote chondrogenesis. WP9QY effectively repairs full-thickness articular cartilage defects in rabbits via intra-articular injection, and inhibits methylmercury-induced reduction of NeuN-positive cells in mouse brain slices. WP9QY can be applied to the research of diseases related to methylmercury-induced neuronal death, cartilage injury, osteoarthritis and bone loss .

HY-P1860A

TNF-α (31-45), human TFA 10+ Cited Publications	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology
TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-P11214

Hydrostatin-TL1 H-TL1	TNF Receptor Integrin NF-κB ERK p38 MAPK JNK Interleukin Related	Inflammation/Immunology
Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a *TNF-α* antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research .

HY-P11108A

RP-182 acetate	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9970

Infliximab Maximum Cited Publications 27 Publications Verification Avakine; CT-P13; SB2; TA-650	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research . The component ratio of this product is Active ingredient : Excipients = 9 : 47.

HY-P9970A

*Infliximab (Anti-TNF-α)* Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .

HY-P991049

Atrosimab ATM-001	TNF Receptor	Metabolic Disease Inflammation/Immunology
Atrosimab is an Fv-Fc1K fusion protein with an EC₅₀ value of 0.37 nM against humans. Atrosimab inhibits TNF-induced TNFR1 activation, release of IL-6 and IL-8, and cell death, and alleviates neuroinflammation. Atrosimab is applicable to research related to inflammatory diseases, neurodegenerative diseases, acute and chronic inflammation, experimental arthritis, non-alcoholic steatohepatitis, and experimental autoimmune encephalomyelitis .

HY-P991400

GSK1995057	TNF Receptor Apoptosis Interleukin Related NF-κB JNK p38 MAPK	Inflammation/Immunology
GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to *TNFR1, blocks the binding of TNF-α* and LT-α, and does not interfere with *TNFR2* signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, *TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1* and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury .

HY-P990008

Atrosab 1 Publications Verification	TNF Receptor Apoptosis	Inflammation/Immunology
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated Apoptosis induction and IL-6 and IL-8 production. Atrosab reduces neurological deficits. Atrosab can be used for research of inflammatory disease. The recommend isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991192

BI-1808	TNF Receptor	Cancer
BI-1808 is a human IgG1 monoclonal antibody that targets *TNFR2by blocking interaction of TNFR2 with ligand TNF*-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8 ⁺ T cells .

HY-P99812

Ragifilimab 1 Publications Verification INCAGN-1876	TNF Receptor	Inflammation/Immunology Cancer
Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab binds to and activates GITR on T cells, which stimulates the immune system to enhance its anti-tumor activity. Ragifilimab can be used for advanced or metastatic solid tumors research .

HY-P99149

*Anti-Mouse TNFR2 Antibody (TR75-54.7)*	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse *TNFR2* IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer .

HY-P99692

Lenercept p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1	TNF Receptor	Inflammation/Immunology
Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble *TNF-receptor* (p55) linked to the Fc portion of human IgG1 .

HY-P99543

Tulinercept OPRX-106; PRX-106; TNFR-Fc	TNF Receptor	Cancer
Tulinercept (OPRX-106) is a recombinant TNF receptor fusion protein fused to an IgG1 Fc domain .

HY-P991195

SIM-0235 SIM1811-03	TNF Receptor	Cancer
SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits *TNFR2*, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

HY-P992399

LBL-019	TNF Receptor NF-κB	Cancer
LBL-019 is a humanized IgG1 monoclonal antibody targeting *TNFR2. LBL-019 costimulates TNFR2* and activates the NF-κB signaling pathway in an Fc crosslinking-dependent manner. LBL-019 can be used for the research of advanced malignant tumors, including hepatocellular carcinoma and melanoma. The recommended isotype control is human IgG1 kappa (HY-P99001) .

Species:	Human (21) Rhesus Macaque (2) Rat (4) Mouse (4) Cynomolgus (4)
Tag:	His (15) Tag Free (3) Avi (4) GST (1) Fc (14)
Source:	HEK293 (27) CHO (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78795

	TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His-Avi) TNFRSF1B; CD120b; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80; p75; p75TNFR	Human	HEK293
	The TNFRII protein is a receptor with high affinity for TNFSF2/TNF-α and low affinity for TNFSF1/lymphotoxin-α, and plays a key role in mediating the metabolic effects of TNF-α. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2 to regulate the apoptotic pathway. TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TNF RII/TNFRSF1B protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78526

	TNF RII/TNFRSF1B Protein, Human (HEK293, mFc) CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Human (HEK293, mFc) is expressed by HEK293 and has a transmembrane region (M1-D257) with mFc tag at the C-terminus.

HY-P701084

	TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B	Human	HEK293
	The TNFRII protein is a receptor with high affinity for TNFSF2/TNF-α and low affinity for TNFSF1/lymphotoxin-α, and plays a key role in mediating the metabolic effects of TNF-α. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2 to regulate the apoptotic pathway. TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TNF RII/TNFRSF1B protein, expressed by HEK293 , with C-His labeled tag.

HY-P705102

	TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, Fc-Avi) CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B	Human	HEK293

HY-P700838

	TNF RI/TNFRSF1A Protein, Cynomolgus (HEK293, His) TNF-R1; TNF-RI; FPF; TBP1; TNF-R55; TNFAR; TNFR60; p55; p60; MS5; p55-R; TNFR1-d2	Cynomolgus	HEK293
	TNFRSF1A Protein exhibits a deficiency in conserved residue(s) crucial for feature annotation propagation. TNF RI/TNFRSF1A Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TNFRSF1A protein, expressed by HEK293 , with C-His labeled tag.

HY-P71914

	TNF RII/TNFRSF1B Protein, Human (183a.a) CD120b; p75; p75 TNF receptor; p75TNFR; p80 TNF alpha receptor; p80 TNF-alpha receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R II; TNF R2; TNF R75; TNF-R2; TNF-RII; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII ; TNFrsf1b; TNR1B_HUMAN; Tumor necrosis factor beta receptor; Tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2	Human	E. coli
	The TNFRII protein is a receptor with high affinity for TNFSF2/TNF-α and low affinity for TNFSF1/lymphotoxin-α, and plays a key role in mediating the metabolic effects of TNF-α. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2 to regulate the apoptotic pathway. TNFRII Protein, Human (183a.a) is the recombinant human-derived TNFRII protein, expressed by E. coli , with tag free.

HY-P70801

	TNF RI/TNFRSF1A Protein, Human (His) Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; TNFAR; TNFR1	Human	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Human (His) is expressed by E. coli with a 6*His tag at the N-terminus.

HY-P76683

	TNF RII/TNFRSF1B Protein, Human (HEK293, His) TNF-R2; CD120b; Tumor necrosis factor receptor superfamily member 1b; p75; TNFr2	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Human (HEK293, His) is expressed by HEK293 with His tag at the C-terminus.

HY-P76108

	TNF RII/TNFRSF1B Protein, Mouse (HEK293, Fc) TNF-R2; CD120b; Tumor necrosis factor receptor superfamily member 1b; p75; TNFr2	Mouse	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Mouse (HEK293, Fc) is expressed by HEK293 and has a transmembrane region with Fc tag at the C-terminus.

HY-P74504

	TNF RI/TNFRSF1A Protein, Rat (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, His) is expressed by HEK293 and has a transmembrane region (M1-A211) with a His tag at the C-terminus.

HY-P74505

	TNF RI/TNFRSF1A Protein, Rat (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, Fc) is expressed by HEK293 and has a transmembrane region with a Fc tag at the C-terminus.

HY-P72444

	TNF RII/TNFRSF1B Protein, Cynomolgus/Rhesus Macaque (HEK293, His) TNF-R2; CD120b; Tumor necrosis factor receptor superfamily member 1b; p75; TNFr2	Rhesus Macaque;Cynomolgus	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is expressed by HEK293 with 6*His tag at the C-terminus.

HY-P77498

	TNF RII/TNFRSF1B Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) TNF-R2; CD120b; Tumor necrosis factor receptor superfamily member 1b; p75; TNFr2	Rhesus Macaque;Cynomolgus	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is expressed by HEK293 and has a transmembrane region (M1-D257) with hFc tag at the C-terminus.

HY-P72443

	TNF RI/TNFRSF1A Protein, Mouse Tumor necrosis factor receptor superfamily member 1A; TNF-R1; CD120a; TNFrsf1a	Mouse	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse is expressed by E. coli and has a transmembrane region (I22-A212).

HY-P73450

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region with a His tag at the C-terminus.

HY-P73449

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region with a Fc tag at the C-terminus.

HY-P72025

	TNF RII/TNFRSF1B Protein, Human (HEK293, hFc) 1 Publications Verification Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD120b; Etanercept; TBP-2; TBPII;	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (HEK293, hFc) is expressed by HEK293 and has a transmembrane region (L23-D257) with hFc tag at the C-terminus.

HY-P71126

	TNF RII/TNFRSF1B Protein, Human (174a.a, HEK293, His) Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; TNFRII; TNF RII	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (174a.a, HEK293, His) is expressed by HEK293 and has a transmembrane region (K288-S461) with 6*His tag at the C-terminus.

HY-P700263

	TNF RI/TNFRSF1A Protein, Human (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Human	HEK293
	The TNFR-1/CD120a protein is a receptor for TNFSF2/TNF-α and TNFSF1/lymphotoxin-α, and initiates caspase-8-mediated apoptosis upon TNF binding. It induces non-cytocidal TNF action, activates acid sphingomyelinase and establishes an antiviral state. TNFR-1/CD120a Protein, Human (HEK293, His) is the recombinant human-derived TNFR-1/CD120a protein, expressed by HEK293 , with C-8*His labeled tag.

HY-P700264

	TNF RI/TNFRSF1A Protein, Human (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Human	HEK293
	The TNFR-1/CD120a protein is a receptor for TNFSF2/TNF-α and TNFSF1/lymphotoxin-α, and initiates caspase-8-mediated apoptosis upon TNF binding. It induces non-cytocidal TNF action, activates acid sphingomyelinase and establishes an antiviral state. TNFR-1/CD120a Protein, Human (HEK293, Fc) is the recombinant human-derived TNFR-1/CD120a protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75918

	TNFRSF3/LTBR Protein, Rat (HEK293, His) Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3	Rat	HEK293
	TNFRSF3/LTBR Protein, Rat (HEK293, His) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Rat (HEK293, His) is expressed by HEK293 cells and is a transmembrane protein (M222-W245) with a His tag at the C-terminus.

HY-P77445

	TNFRSF3/LTBR Protein, Cynomolgus (HEK293, Fc) Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3	Cynomolgus	HEK293
	TNFRSF3/LTBR Protein,Cynomolgus (HEK293, Fc) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Cynomolgus (HEK293, Fc) is expressed by HEK293 cells and is a transmembrane protein (M225-W248) with a His tag at the C-terminus.

HY-P75917

	TNFRSF3/LTBR Protein, Rat (HEK293, Fc) Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3	Rat	HEK293
	TNFRSF3/LTBR Protein, Rat (HEK293, Fc) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Rat (HEK293, Fc) is expressed by HEK293 cells with a His tag at the C-terminus.

HY-P72806

	TNFRSF3/LTBR Protein, Human (HEK293, Fc) Tumor Necrosis Factor Receptor Superfamily Member 3; Lymphotoxin-Beta Receptor; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor 2-Related Protein; Tumor Necrosis Factor Receptor Type III; TNF-RIII; TNFR-III; LTBR; D12S370; TNFCR; TNFR3; TNFRSF3	Human	HEK293
	TNFRSF3/LTBR Protein, Human (HEK293, Fc) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Human (HEK293, Fc) is expressed by HEK293 cells and is a transmembrane protein (L228-W248) with a Fc tag at the C-terminus.

HY-P702570

	TRADD Protein, Human (His) TNFR1 associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; tradd; TRADD_HUMAN; Tumor necrosis factor receptor type 1 associated DEATH domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein	Human	E. coli
	The TRADD protein acts as a linker for TNFRSF1A/TNFR1 and mediates its interaction with FADD. TRADD induces TNF-induced responses: apoptosis and NF-kappa-B activation. TRADD Protein, Human (His) is the recombinant human-derived TRADD protein, expressed by E. coli , with C-6*His labeled tag.

HY-P70345

	TNFRSF3/LTBR Protein, Human (HEK293, His) rHuTumor necrosis factor receptor superfamily member 3/TNFRSF3, His; Tumor Necrosis Factor Receptor Superfamily Member 3; Lymphotoxin-Beta Receptor; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor 2-Related Protein; Tumor Necrosis Factor Receptor Type III; TNF-RIII; TNFR-III; LTBR; D12S370; TNFCR; TNFR3; TNFRSF3	Human	HEK293
	TNFRSF3/LTBR Protein, Human (HEK293, His) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Human (HEK293, His) is expressed by HEK293 cells and is a transmembrane protein (L228-W248) with a His tag at the C-terminus.

HY-P704932

	TNFRSF3/LTBR Protein, Human (HEK293, His-Avi) rHuTumor necrosis factor receptor superfamily member 3/TNFRSF3, His; Tumor Necrosis Factor Receptor Superfamily Member 3; Lymphotoxin-Beta Receptor; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor 2-Related Protein; Tumor Necrosis Factor Receptor Type III; TNF-RIII; TNFR-III; LTBR; D12S370; TNFCR; TNFR3; TNFRSF3	Human	HEK293

HY-P70683

	GITR Protein, Human (HEK293, hFc) Tumor necrosis factor receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR	Human	HEK293
	GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (HEK293, hFc) is a recombinant protein with a C-terminal Fc label, It consists of 136 amino acids (Q26-E161) and is produced in HEK293 cells.

HY-P705130

	TNFRSF3/LTBR Protein, Human (Biotinylated, HEK293, His-Avi) rHuTumor necrosis factor receptor superfamily member 3/TNFRSF3, His; Tumor Necrosis Factor Receptor Superfamily Member 3; Lymphotoxin-Beta Receptor; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor 2-Related Protein; Tumor Necrosis Factor Receptor Type III; TNF-RIII; TNFR-III; LTBR; D12S370; TNFCR; TNFR3; TNFRSF3	Human	HEK293

HY-P70822

	GITR Protein, Human (T45A, HEK293, mFc) Tumor necrosis factor receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR	Human	HEK293
	GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (T45A, HEK293, mFc) is a recombinant protein with a C-terminal Fc label and T at position 45 is mutated to A. It consists of 136 amino acids (Q26-E161) and is produced in HEK293 cells.

HY-P7305

	TNF RI/TNFRSF1A Protein, Human (CHO) rHuTNFRI; TNFRSF1A; TNFAR; CD120a	Human	CHO
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Human (CHO) is expressed by CHO and has a transmembrane region (D41-N201) .

HY-P70536

	TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) TNF-RII; TNFRII; TNF RII; Tumor necrosis factor receptor superfamily member 1B; TNFRSF1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) is expressed by HEK293 and has a transmembrane region (P24-T206) with mFc tag at the C-terminus.

HY-P71537

	TRAP1 Protein, Human (GST) Heat shock protein 75kDa; Heat shock protein 75kDa, mitochondrial; HSP 75; HSP75; HSP90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein	Human	E. coli
	As a chaperone with ATPase activity, TRAP1 protein plays a crucial role in protecting mitochondrial function and polarization, especially downstream of PINK1 and mitochondrial complex I. TRAP1 acts as a negative regulator of mitochondrial respiration, affecting the balance between oxidative phosphorylation and aerobic glycolysis. TRAP1 Protein, Human (GST) is the recombinant human-derived TRAP1 protein, expressed by E. coli , with N-GST labeled tag.

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Host:	Mouse (8) Rabbit (4)
Reactivity:	Human (11) mouse (1) rat (1) Rat (4) Mouse (8) Monkey (1)
Application:	IHC-P (5) ICC/IF (7) IF-Tissue (1) IP (5) IHC-F (1) WB (10) FC (7) ELISA (7)
Isotype:	IgG (4) IgG1 (2) IgG2a (3) IgG2b (2)
Conjugation:	Non-conjugated (12) Biotin (4)
Clonality:	Polyclonal (1) Monoclonal (5) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (8)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84158

	TNFRSF1A Antibody (YA3855) FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55	ICC/IF, FC, ELISA	Human
	TNFRSF1A Antibody (YA3855) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TNFRSF1A.

HY-P84158A

	TNFRSF1A Antibody (YA3855)(PBS only) FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55	ICC/IF, FC, ELISA	Human
	TNFRSF1A Antibody (YA3855) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TNFRSF1A.

HY-P84171

	TNF Receptor 2 Antibody (YA3868) TNFRSF1B; p75; TBPII; TNFBR; TNFR2; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II	WB, FC, ELISA	Human, Mouse
	TNF Receptor 2 Antibody (YA3868) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TNF Receptor 2.

HY-P84171A

	TNF Receptor 2 Antibody (YA3868)(PBS only) TNFRSF1B; p75; TBPII; TNFBR; TNFR2; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II	WB, FC, ELISA	Human, Mouse
	TNF Receptor 2 Antibody (YA3868) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TNF Receptor 2.

HY-P84288

	LTBR Antibody (YA3985) TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III	WB, FC, ELISA	Human, Mouse
	LTBR Antibody (YA3985) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LTBR.

HY-P84288A

	LTBR Antibody (YA3985)(PBS only) TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III	WB, FC, ELISA	Human, Mouse
	LTBR Antibody (YA3985) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LTBR.

HY-P80915

	TNF Receptor 2 Antibody CD120b; p75 TNF receptor; p80 TNF alpha receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R75; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII; TNFrsf1b	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	TNF Receptor 2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNF Receptor 2.

HY-P810217

	TNF-R1 Antibody (YA9561)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	mouse, rat
	TNF-R1 Antibody (YA9561) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TNF-R1.

HY-P82531

	TRADD Antibody (YA2276) AA930854; TNFR1 associated DEATH domain protein; tradd	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	TRADD Antibody (YA2276) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRADD.

HY-P85568

	cIAP2 Antibody (YA5260) AIP 1; AIP1; API 2; API2; API2; Apoptosis inhibitor 2; Baculoviral IAP repeat containing 3; Baculoviral IAP repeat containing protein 3; Baculoviral IAP repeat-containing protein 3; BIRC 3; BIRC3; BIRC3; BIRC3_HUMAN; C IAP2; C-IAP2; CIAP 2; CIAP 2; CIAP2; HAIP 1; HAIP1; HAIP1; HIAP 1; HIAP-1; HIAP1; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; Inhibitor of apoptosis protein 1; MALT 2; MALT2; Mammalian IAP homolog C; MIHC; MIHC; RING finger protein 49; RNF49; TNFR2 TRAF signaling complex protein 1; TNFR2 TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 1.	WB	Human, Monkey
	cIAP2 Antibody (YA5260) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to cIAP2.

HY-P83029

	p75 NGF Receptor Antibody (YA2774) CD271 antibody; CD271 antigen antibody; Gp80 LNGFR antibody; Gp80-LNGFR antibody; Low affinity nerve growth factor receptor antibody; Low affinity neurotrophin receptor p75NTR antibody; Low-affinity nerve growth factor receptor antibody; Nerve growth factor receptor antibody; Nerve growth factor receptor TNFR superfamily member 16 antibody; NGF receptor antibody; Ngfr antibody; p75 ICD antibody; p75 Neurotrophin receptor antibody; p75 NTR antibody; p75(NTR) antibody; p75NTR antibody; TNFR Superfamily Member 16 antibody; TNFRSF16 antibody; TNR16_HUMAN antibody; Tumor necrosis factor receptor superfamily member 16 antibody;	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	p75 NGF Receptor Antibody (YA2774) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p75 NGF Receptor.

HY-P83029A

	p75 NGF Receptor Antibody (YA2774)(PBS only) CD271 antibody; CD271 antigen antibody; Gp80 LNGFR antibody; Gp80-LNGFR antibody; Low affinity nerve growth factor receptor antibody; Low affinity neurotrophin receptor p75NTR antibody; Low-affinity nerve growth factor receptor antibody; Nerve growth factor receptor antibody; Nerve growth factor receptor TNFR superfamily member 16 antibody; NGF receptor antibody; Ngfr antibody; p75 ICD antibody; p75 Neurotrophin receptor antibody; p75 NTR antibody; p75(NTR) antibody; p75NTR antibody; TNFR Superfamily Member 16 antibody; TNFRSF16 antibody; TNR16_HUMAN antibody; Tumor necrosis factor receptor superfamily member 16 antibody;	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	p75 NGF Receptor Antibody (YA2774) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p75 NGF Receptor.