1049741-03-8
Chemical Structure
SPD304 dihydrochloride
- CAS No.: 1049741-03-8
- Formula:C32H34Cl2F3N3O2
- Molecular Weight:620.53
IUPAC Name: 6,7-dimethyl-3-((methyl(2-(methyl((1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)methyl)amino)ethyl)amino)methyl)-4H-chromen-4-one dihydrochloride
InChIKey: GOZMBJCYMQQACI-UHFFFAOYSA-N
SMILES: O=C1C(CN(C)CCN(C)CC2=CN(C3=CC=CC(C(F)(F)F)=C3)C4=C2C=CC=C4)=COC5=CC(C)=C(C)C=C15.[H]Cl.[H]Cl
Biological Activity: SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2].
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SPD304 dihydrochloride | 99.82% | SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α. | ||||||||||||||||||||
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SPD304 dihydrochloride (Standard) | ≥98% | SPD304 dihydrochloride (Standard) is the analytical standard of SPD304 (dihydrochloride) (HY-111255A). This product is intended for research and analytical applications. SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α. | ||||||||||||||||||||
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