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Results for "

Thalidomide-4-Br

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153368
    Zomiradomide

    KT-413

    		 PROTACs IRAK NF-κB IFNAR Cancer
    Zomiradomide is an orally active PROTAC degrader for IRAK4 (DC50=6 nM), thereby inhibiting the NF-κB signaling pathway. Zomiradomide acts also as a molecular glue, recruiting Ikaros and Aiolos, and mediating their degradation (DC50 for Ikaros is 1 nM), thereby activating the type I IFN signaling pathway . (Pink: target protein ligand PROTAC IRAK4 ligand-5 (HY-168311), Blue: E3 ligase ligand Thalidomide-4-Br (HY-W039116), Black: linker (HY-168313))
    Zomiradomide
  • HY-W039116
    Thalidomide-4-Br

    		Drug Derivative Neurological Disease Inflammation/Immunology Cancer
    Thalidomide-4-Br (compound 53) is a compound with a bromodomain. Thalidomide-4-Br can be used in the research of inflammation, tumor and neurology .
    Thalidomide-4-Br
  • HY-W458018
    Thalidomide-4-Br,7-F

    		Ligands for E3 Ligase Cancer
    Thalidomide-4-Br,7-F is an E3 ligase activator featuring a bromine and a fluorine. E3 ligase is a protein that marks other proteins for proteolytic destruction by labeling them with ubiquitin. Both halogens may be substituted for further derivitization.
    Thalidomide-4-Br,7-F

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