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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Topotecan
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Topotecan" in MCE Product Catalog:
39
39 Publications Verification
Synonyms: SKF 104864A hydrochloride; NSC 609669 hydrochloride
Category:
Alkaloids Monophenols Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer
Target:
39
39 Publications Verification
Cat. No.: HY-13768
CAS No.: 123948-87-8
Synonyms: SKF 104864A; NSC 609669
Target:
Research Areas:
Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity .
2
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Research Areas:
PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768)-induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis .
Cat. No.: HY-161853
CAS No.: 2446767-14-0
Target:
Research Areas:
TX-2552 is an orally active tyrosine DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 value of 0.62 μM. TX-2552 can enhance the clastogenic activity of Topotecan (HY-13768) in mouse bone marrow cells, as well as the anti-tumor effect of Topotecan (HY-13768) in Krebs-2 ascites tumor mice .
Cat. No.: HY-161152
CAS No.: 2190506-29-5
Target:
Research Areas:
DNA relaxation-IN-1 (Compound 27) is a DNA ligase 1 DNA Lig1) inhibitor. DNA relaxation-IN-1 inhibits DNA ligation and disrupts the DNA relaxing activity of DNA Lig1. DNA relaxation-IN-1 induces Apoptosis. DNA relaxation-IN-1, in combination with Topotecan (HY-13768), exhibits synergistic antiproliferative effects against colorectal cancer .
Cat. No.: HY-13768S1
CAS No.: 1044904-10-0
Cat. No.: HY-132685AS
CAS No.: 2701830-42-2
Cat. No.: HY-132685S
CAS No.: 1217633-79-8
Cat. No.: HY-13768C
CAS No.: 1044663-62-8
Synonyms: SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate
Target:
Research Areas:
Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity .
Cat. No.: HY-13768AR
CAS No.: 119413-54-6
Synonyms: SKF 104864A hydrochloride (Standard); NSC 609669 hydrochloride (Standard)
Cat. No.: HY-13768D
CAS No.: 123948-88-9
Synonyms: SKF 104864A acetate; NSC 609669 acetate
Target:
Research Areas:
Topotecan acetate is a topoisomerase inhibitor.
Cat. No.: HY-13768S
CAS No.: 1133355-98-2
Synonyms: SKF 104864A-d5; NSC 609669-d5
Cat. No.: HY-W740426
CAS No.: 190710-79-3
Target:
Research Areas:
N-Desmethyltopotecan is a metabolite of Topotecan (HY-13768), and it can be detected in plasma, urine and feces .
Cat. No.: HY-W740425
Cat. No.: HY-13768S2
Synonyms: SKF 104864A-d6 dihydrochloride; NSC 609669-d6 dihydrochloride
Cat. No.: HY-183546
Research Areas:
TDP1-IN-6 is a TDP1 inhibitor with an IC50 of 1.52 μM. Combination of TDP1-IN-6 with Topotecan (HY-13768) enhances DNA damage, induces Apoptosis, triggers S-phase cell cycle arrest, and promotes Ferroptosis. TDP1-IN-6 can be used for the research of cervical cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
