Topotecan acetate
Based on 15 publication(s) in Google Scholar
Topotecan acetate is a topoisomerase inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 123948-88-9
- Formula: C25H27N3O7
- Molecular Weight:481.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Topotecan acetate
More- Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]
- J Exp Clin Cancer Res. 2018 Dec 20;37(1):321. [Abstract]
- MedComm (2020). 2025 Nov 29;6(12):e70517. [Abstract]
- Cell Death Dis. 2024 Jan 18;15(1):66. [Abstract]
- Cell Commun Signal. 2024 Jun 13;22(1):325. [Abstract]
- Acta Pharmacol Sin. 2021 Jan;42(1):108-114. [Abstract]
- Cancer Immunol Res. 2023 May 3;11(5):583-599. [Abstract]
- Pharmaceutics. 2022 Nov 24;14(12):2595. [Abstract]
- J Biomed Inform. 2023 Jun:142:104383. [Abstract]
- Sci Rep. 2019 Oct 22;9(1):15099. [Abstract]
- Cancers (Basel). 2021 Dec 31;14(1):193. [Abstract]
- J Cell Mol Med. 2026 Apr;30(7):e71101. [Abstract]
- J Immunol. 2022 Jul 1;209(1):171-179. [Abstract]
- Phytochemistry. 2021 Nov:191:112910. [Abstract]
- bioRxiv. 2023 Apr 14.
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IF
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WB
All Topoisomerase Isoforms
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Biological Activity
Chemical Information
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CAS No. 123948-88-9
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Molecular Weight 481.50
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Formula C25H27N3O7
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SMILES
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.CC(O)=O
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Synonyms
SKF 104864A acetate; NSC 609669 acetate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
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Journal Impact Factor
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Most Recent
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Nat Commun
Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis. [Abstract]2019 Aug 21;10(1):3761. PMID: 31434880
Topotecan acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]
Topotecan (10 mg/kg; Intraperitoneal injection). Representative images and the apoptotic rate the indicated chemotherapy-treated xenograft tumors.
Topotecan acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]
Topotecan (10 mg/kg; Intraperitoneal injection). IB analysis of the level of cleaved-caspase 3 and cleaved-PARP1 in the indicated chemotherapy-treated xenograft tumors. GAPDH served as the loading control.
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J Exp Clin Cancer Res
Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3η/NF-κB feedback loop. [Abstract]2018 Dec 20;37(1):321. PMID: 30572915 -
MedComm (2020)
KSQ-4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1-Mediated Multidrug Resistant Cancers. [Abstract]2025 Nov 29;6(12):e70517. PMID: 41328326 -
Cell Death Dis
2024 Jan 18;15(1):66. PMID: 38238307 -
Cell Commun Signal
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo. [Abstract]2024 Jun 13;22(1):325. PMID: 38872211 -
Acta Pharmacol Sin
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway. [Abstract]2021 Jan;42(1):108-114. PMID: 32398685 -
Cancer Immunol Res
Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity. [Abstract]2023 May 3;11(5):583-599. PMID: 36921097 -
Pharmaceutics
Encorafenib Acts as a Dual-Activity Chemosensitizer through Its Inhibitory Effect on ABCC1 Transporter In Vitro and Ex Vivo. [Abstract]2022 Nov 24;14(12):2595. PMID: 36559089 -
J Biomed Inform
2023 Jun:142:104383. PMID: 37196989 -
Sci Rep
Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. [Abstract]2019 Oct 22;9(1):15099. PMID: 31641154 -
Cancers (Basel)
Targeted Disruption of E6/p53 Binding Exerts Broad Activity and Synergism with Paclitaxel and Topotecan against HPV-Transformed Cancer Cells. [Abstract]2021 Dec 31;14(1):193. PMID: 35008354 -
J Cell Mol Med
2026 Apr;30(7):e71101. PMID: 41896195 -
J Immunol
Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation. [Abstract]2022 Jul 1;209(1):171-179. PMID: 35725272 -
Phytochemistry
2021 Nov:191:112910. PMID: 34481345 -
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)