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Art. -Nr.: HY-13768D

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Topotecan acetate

Name: Topotecan acetate
Brand: MedChemExpress
SKU: HY-13768D
Availability: PreOrder

(Synonyms: SKF 104864A acetate; NSC 609669 acetate)

15 Cited Publications

Kundenbewertung

Based on 15 publication(s) in Google Scholar

Topotecan acetate is a topoisomerase inhibitor.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 123948-88-9
Formel: C₂₅H₂₇N₃O₇
Molecular Weight:481.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Topotecan acetate Chemical Structure

CAS. Nr.: 123948-88-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

Topotecan acetate is a topoisomerase inhibitor.

Alle Topoisomerase Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 123948-88-9
Molecular Weight 481.50
Formel C₂₅H₂₇N₃O₇
SMILES

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.CC(O)=O
Synonyms

SKF 104864A acetate; NSC 609669 acetate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (15)

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Journal Impact Factor

Nat Commun

Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis. [Abstract]

2019 Aug 21;10(1):3761. PMID: 31434880

Topotecan acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]

Topotecan (10 mg/kg; Intraperitoneal injection). Representative images and the apoptotic rate the indicated chemotherapy-treated xenograft tumors.

Topotecan acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]

Topotecan (10 mg/kg; Intraperitoneal injection). IB analysis of the level of cleaved-caspase 3 and cleaved-PARP1 in the indicated chemotherapy-treated xenograft tumors. GAPDH served as the loading control.
J Exp Clin Cancer Res

Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3η/NF-κB feedback loop. [Abstract]

2018 Dec 20;37(1):321. PMID: 30572915
MedComm (2020)

KSQ-4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1-Mediated Multidrug Resistant Cancers. [Abstract]

2025 Nov 29;6(12):e70517. PMID: 41328326
Cell Death Dis

Transcription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis. [Abstract]

2024 Jan 18;15(1):66. PMID: 38238307
Cell Commun Signal

BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo. [Abstract]

2024 Jun 13;22(1):325. PMID: 38872211
Acta Pharmacol Sin

Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway. [Abstract]

2021 Jan;42(1):108-114. PMID: 32398685
Cancer Immunol Res

Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity. [Abstract]

2023 May 3;11(5):583-599. PMID: 36921097
Pharmaceutics

Encorafenib Acts as a Dual-Activity Chemosensitizer through Its Inhibitory Effect on ABCC1 Transporter In Vitro and Ex Vivo. [Abstract]

2022 Nov 24;14(12):2595. PMID: 36559089
J Biomed Inform

From Centralized to Ad-Hoc Knowledge Base Construction for Hypotheses Generation. [Abstract]

2023 Jun:142:104383. PMID: 37196989
Sci Rep

Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. [Abstract]

2019 Oct 22;9(1):15099. PMID: 31641154
Cancers (Basel)

Targeted Disruption of E6/p53 Binding Exerts Broad Activity and Synergism with Paclitaxel and Topotecan against HPV-Transformed Cancer Cells. [Abstract]

2021 Dec 31;14(1):193. PMID: 35008354
J Cell Mol Med

Inactivation of CDK12 Enhances Mitochondrial Efficiency to Suppress DNA Damage. [Abstract]

2026 Apr;30(7):e71101. PMID: 41896195
J Immunol

Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation. [Abstract]

2022 Jul 1;209(1):171-179. PMID: 35725272
Phytochemistry

Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis. [Abstract]

2021 Nov:191:112910. PMID: 34481345
bioRxiv

2023 Apr 14.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kollmannsberger C, et al. Topotecan - A novel topoisomerase I inhibitor: pharmacology and clinical experience. Oncology. 1999;56(1):1-12. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Topotecan acetate

15 Cited Publications

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Biologische Aktivität
- Beschreibung
Chemical Information
Publications (15)
Reinheit & Dokumentation
Verweise

1/16
1/16

Topotecan acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]

Customer Validation
Topotecan (10 mg/kg; Intraperitoneal injection). Representative images and the apoptotic rate the indicated chemotherapy-treated xenograft tumors.
1/16

Topotecan acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]

Customer Validation
Topotecan (10 mg/kg; Intraperitoneal injection). IB analysis of the level of cleaved-caspase 3 and cleaved-PARP1 in the indicated chemotherapy-treated xenograft tumors. GAPDH served as the loading control.

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Topotecan acetate

Publications Citing Use of MedChemExpress (MCE) Topotecan acetate

Alle Topoisomerase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Chemical Information

Publications (15)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bioz

Keywords

Your Recently Viewed Products

Topotecan acetate

Publications Citing Use of MedChemExpress (MCE) Topotecan acetate

Alle Topoisomerase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Chemical Information

Publications (15)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs