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Cat. No.: HY-13768S2

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Topotecan-d₆ dihydrochloride

(Synonyms: SKF 104864A-d₆ dihydrochloride; NSC 609669-d₆ dihydrochloride)

Topotecan-d₆ dihydrochloride (SKF 104864A-d₆ dihydrochloride) is the deuterium labeled Topotecan dihydrochloride. Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity.

For research use only. We do not sell to patients.

Formula: C₂₃H₁₉D₆Cl₂N₃O₅
Molecular Weight:500.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Topotecan-d₆ dihydrochloride Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Topoisomerase Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 123948-87-8
Molecular Weight 500.40
Formula C₂₃H₁₉D₆Cl₂N₃O₅
SMILES

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])C(O)=CC=C5N=C4C3=C2)=O.Cl.Cl
Synonyms

SKF 104864A-d₆ dihydrochloride; NSC 609669-d₆ dihydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.