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4 Results for "
Vernakalant
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "Vernakalant" in MCE Product Catalog:
Cat. No.: HY-14182
CAS No.: 794466-70-9
Synonyms: RSD1235
Target:
Research Areas:
Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.
3
3 Cited Publications
Synonyms: RSD1235 hydrochloride
Target:
Research Areas:
Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na + and atria-preferred K + channel blocker. IC50 for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channel wt, Kv1.5 channel I508F, Kv1.5 channel T479A, respectively.
Cat. No.: HY-14182S
CAS No.: 866455-16-5
Synonyms: RSD1235-d6 hydrochloride
Target:
Research Areas:
AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1.1 μM for KCa2.2 (SK2) and KCa2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) .
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Protocols
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