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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Vpr
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Vpr" in MCE Product Catalog:
2
1
Target:
Cat. No.: HY-175343
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OICR-41103 is an effective, selective, cell-active DCAF1 small molecule chemical probe that targets the DCAF1 WDR domain and replaces the viral Vpr protein. The binding Ki value of OICR-41103 and DCAF1 is less than 2 nM .
Cat. No.: HY-B0751R
CAS No.: 23110-15-8
Synonyms: Amebacilin (Standard); NSC9168 (Standard)
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Target:
Cat. No.: HY-175343A
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OICR-41103N is the negative control form of OICR-41103 (HY-175343). OICR-41103 is an effective, selective, cell-active DCAF1 small molecule chemical probe (Ki<2 nM) that targets the DCAF1 WDR domain and replaces the viral Vpr protein .
Cat. No.: HY-P11640
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Research Areas:
Cat. No.: HY-176964
CAS No.: 19651-46-8
Synonyms: PheCA
N-Choloylphenylalanine (Compound 6273) (PheCA) is a VPR-induced growth arrest inhibitor. N-Choloylphenylalanine alleviates VPR-induced growth arrest. N-Choloylphenylalanine can be used in yeast and HIV-1 infection research .
Cat. No.: HY-P704060
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Vpr; Protein Vpr; R ORF protein; Viral protein R; Vpr, HIV-1 group M subtype C
Cat. No.: HY-183988
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OICR409946 is a self-dimerization-induced proximity-targeting chimera (SDIPTAC) targeting DCAF1, with a Kd value of 6200 nM. OICR409946 binds to DCAF1, induces head-to-tail homodimerization, sterically blocks the Vpr binding interface, prevents the recruitment of Vpr to the CRL4DCAF1 complex, and inhibits Vpr-dependent HIV replication. OICR409946 can be used in studies related to HIV infection (DCAF1 ligand: (HY-169390); Linker: (HY-130659)) .
Cat. No.: HY-P704061
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Vpr; Protein Vpr; R ORF protein; Viral protein R
Cat. No.: HY-P704057
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Vpr; Protein Vpr; R ORF protein; Viral protein R
Cat. No.: HY-P703270
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DCAF1; HIV-1 Vpr-Binding Protein; Prev. VprBP; MGC102804; KIAA0800; RIP; Serine/Threonine-Protein Kinase VprBP; Vpr-Binding Protein; DDB1- And CUL4-Associated Factor 1; Protein VprBP; Vpr (HIV-1) Binding Protein; VprBP; DDB1 And CUL4 Associated Factor 1;
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Source:
Cat. No.: HY-P703271
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: DCAF1; HIV-1 Vpr-Binding Protein; Prev. VprBP; MGC102804; KIAA0800; RIP; Serine/Threonine-Protein Kinase VprBP; Vpr-Binding Protein; DDB1- And CUL4-Associated Factor 1; Protein VprBP; Vpr (HIV-1) Binding Protein; VprBP; DDB1 And CUL4 Associated Factor 1;
Species:
Source:
Cat. No.: HY-B0751S
Synonyms: Amebacilin-13C26; NSC9168-13C26
Cat. No.: HY-181164
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PROTAC BRD4 Degrader-43 is a BRD4 PROTAC degrader. PROTAC BRD4 Degrader-43 recruits the DCAF1-DDB1-Cul4A E3 ligase complex via a Vpr-derived peptide moiety to induce BRD4 ubiquitination and degradation through the ubiquitin-proteasome system. PROTAC BRD4 Degrader-43 exhibits potent HIV latency-reversing activity. PROTAC BRD4 Degrader-43 can be used for the research of HIV-1 latent infection . (Pink: BRD4 ligand (HY-13030); Blue: Cul4A-DDB1-DCAF1 ligand (HY-P11640); Black: conjugate of PEG linker + cell-penetrating peptide (HY-P2483))
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
