2798-25-6
Chemical Structure
Bellidifolin
- CAS No.: 2798-25-6
- Formula:C14H10O6
- Molecular Weight:274.23
IUPAC Name: 1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one
InChIKey: JDIORNFCMMYMLF-UHFFFAOYSA-N
SMILES: O=C1C2=C(OC3=C1C(O)=CC=C3O)C=C(OC)C=C2O
Biological Activity:
Bellidifolin is an orally active compound with antiproliferative, anti-inflammatory and antioxidant properties. Bellidifolin modulates key signaling pathways including STAT3, PI3K-Akt, mTOR and BRD4, and inhibits the viral protein R (Vpr). Bellidifolin induces cell cycle arrest and apoptosis, exerts significant antifibrotic effects, and protects the heart, liver and nervous system. Bellidifolin is applicable to the research of various diseases such as lung cancer, non-alcoholic fatty liver disease, myocardial hypertrophy and ischemic cranial nerve injury[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bellidifolin | 99.74% | Bellidifolin is an orally active compound with antiproliferative, anti-inflammatory and antioxidant properties. Bellidifolin modulates key signaling pathways including STAT3, PI3K-Akt, mTOR and BRD4, and inhibits the viral protein R (Vpr). Bellidifolin induces cell cycle arrest and apoptosis, exerts significant antifibrotic effects, and protects the heart, liver and nervous system. Bellidifolin is applicable to the research of various diseases such as lung cancer, non-alcoholic fatty liver disease, myocardial hypertrophy and ischemic cranial nerve injury. |
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- [1]. Woo SY, et al. Viral protein R inhibitors from Swertia chirata of Myanmar. J Biosci Bioeng. 2019 May 7.
- [2]. Yan L, et al. Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3/COX-2 Expression and Protein Activity. J Oncol. 2020 Nov 21;2020:1723791. [Content Brief]
- [3]. Zhao ZY, et al. Protective effects of bellidifolin in hypoxia-induced in pheochromocytoma cells (PC12) and underlying mechanisms. J Toxicol Environ Health A. 2017;80(22):1187-1192. [Content Brief]
- [4]. Zhou D, et al. Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4. Cell Death Discov. 2023;9(1):279. Published 2023 Aug 1. [Content Brief]
- [5]. Xue J, et al. A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F. J Biomed Res. 2024;38(5):451-463. [Content Brief]
- [6]. Yao TT, et al. Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF-β Signalling Activation to Ameliorate Myocardial Fibrosis. Evid Based Complement Alternat Med. 2022 May 9;2022:6841276. [Content Brief]
Keywords
