OICR409946

OICR409946 (5-50000 nM; 240 s association, 0 s final dissociation) binds to the purified DCAF1 WDR domain with a K_D value of 6200 nM; meanwhile, this compound induces the formation of stable DCAF1 dimers, with the ternary complex having a K_D value of 200 nM and a residence time of 26 min^[1].
OICR409946 (0.16-20 μM; 72 h) exhibits no cytotoxicity toward primary monocyte-derived macrophages even at concentrations up to 20 μM following a 72 h incubation^[1].
OICR409946 (0.4-4 μM; pre-treatment for 2 hours, followed by 6 days post-infection) does not alter HIV-1 infection levels in primary monocyte-derived macrophages at concentrations of 0.4 μM or 4 μM^[1].
OICR409946 (0.31-10 μM; 4 days) inhibits HIV replication in activated primary CD4⁺ T cells in a dose-dependent manner (significant inhibition is observed starting at 0.31 μM in Donor 2 and at 1.25 μM in Donor 1), and induces no cytotoxicity at concentrations up to 10 μM^[1].
Incubation with OICR409946 (0.4-4 μM; 3 days) for 3 days does not significantly upregulate CD206 expression in primary monocyte-derived macrophages, even at the highest concentration of 4 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.