OICR409946 

OICR409946 is a self-dimerization-induced proximity-targeting chimera (SDIPTAC) targeting DCAF1, with a K_d value of 6200 nM. OICR409946 binds to DCAF1, induces head-to-tail homodimerization, sterically blocks the Vpr binding interface, prevents the recruitment of Vpr to the CRL4_DCAF1 complex, and inhibits Vpr-dependent HIV replication. OICR409946 can be used in studies related to HIV infection (DCAF1 ligand: (HY-169390); Linker: (HY-130659))^[1].

OICR409946 (5-50000 nM; 240 s association, 0 s final dissociation) binds to the purified DCAF1 WDR domain with a K_D value of 6200 nM; meanwhile, this compound induces the formation of stable DCAF1 dimers, with the ternary complex having a K_D value of 200 nM and a residence time of 26 min^[1].
OICR409946 (0.16-20 μM; 72 h) exhibits no cytotoxicity toward primary monocyte-derived macrophages even at concentrations up to 20 μM following a 72 h incubation^[1].
OICR409946 (0.4-4 μM; pre-treatment for 2 hours, followed by 6 days post-infection) does not alter HIV-1 infection levels in primary monocyte-derived macrophages at concentrations of 0.4 μM or 4 μM^[1].
OICR409946 (0.31-10 μM; 4 days) inhibits HIV replication in activated primary CD4⁺ T cells in a dose-dependent manner (significant inhibition is observed starting at 0.31 μM in Donor 2 and at 1.25 μM in Donor 1), and induces no cytotoxicity at concentrations up to 10 μM^[1].
Incubation with OICR409946 (0.4-4 μM; 3 days) for 3 days does not significantly upregulate CD206 expression in primary monocyte-derived macrophages, even at the highest concentration of 4 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1393.09

C₆₄H₇₀Cl₄F₄N₈O₁₄

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• [1]. Mabanglo MF, et al. Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication. J Med Chem. 2026;69(10):12240-12259.