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WSU-DLCL2

" in MedChemExpress (MCE) Product Catalog:

13

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阻害性抗体

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同位体標識化合物

製品番号 製品名 Target 研究分野 構造式
  • HY-P99349
    Loncastuximab tesirine

    Loncastuximab tesirine-lpyl; ADCT-402

    		 Antibody-Drug Conjugates (ADCs) Apoptosis Cancer
    Loncastuximab tesirine is a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC). The antibody portion is Loncastuximab (HY-P99711), and the drug-linker conjugate for ADC is Tesirine (HY-128952). Once bound to CD19 on the cell membrane, loncastuximab tesirine is rapidly internalised and triggers cell death. Loncastuximab tesirin induces cell apoptosis, it can be used for the research of diffuse large B-cell lymphoma [2].
    Loncastuximab tesirine
  • HY-107769
    Duocarmycin TM
    1 Publications Verification

    CBI-TMI

    		 ADC Payload DNA Alkylator/Crosslinker Antibiotic Cancer
    Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.
    Duocarmycin TM
  • HY-149923
    GPX4-IN-4

    		Glutathione Peroxidase Cancer
    GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer .
    GPX4-IN-4
  • HY-19551
    Apogossypolone

    ApoG2

    		 Bcl-2 Family Apoptosis Autophagy Fungal ROS Kinase Infection Cancer
    Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy [2]. Apogossypolone also has antifungal activity .
    Apogossypolone
  • HY-149726
    EZH2-IN-17

    		Histone Methyltransferase Cancer
    EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively) .
    EZH2-IN-17
  • HY-175502
    MGD-22

    		Molecular Glues IKZF Family Apoptosis Cancer
    MGD-22, a molecular glue, is an orally active IKZF1/2/3 degrader with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. MGD-22 exhibits extremely potent anti-proliferative activity against diverse hematological cancer cells. MGD-22 induces apoptosis in cancer cells. MGD-22 demonstrates potent anti-tumor efficacy in mice bearing NCI-H929 xenografts or WSU-DLCL-2 xenografts. MGD-22 can be used for the study of hematological cancers, including multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL) .
    MGD-22
  • HY-149463
    EZH2-IN-16

    		Histone Methyltransferase Cancer
    EZH2-IN-16 (Compound 24) is an inhibitor for histone methyltransferase (EZH2). EZH2-IN-16 inhibits EZH2 and EZH2 Y641F, with IC50 of 37.6 and 79.1 nM. EZH2-IN-16 inhibits proliferation of WSU-DLCL2, with GI50 of 0.2 μM .
    EZH2-IN-16
  • HY-172430S
    Epaldeudomide

    		TNF Receptor Cancer
    Epaldeudomide (Compound A406) is the inhibitor for TNF-α (>50% inhibition rate at 100 nM). Epaldeudomide inhibits the proliferation of cancer cells MM.1S (IC50 < 300 nM), WSU-DLCL-2 (IC50 < 100 nM) and Rec-1 (IC50 < 100 nM). Epaldeudomide exhibits antineoplastic activity .
    Epaldeudomide
  • HY-169958
    EZH2-IN-22

    		Histone Methyltransferase Cancer
    EZH2-IN-22 (example 92) is a potent EZH2 inhibitor with IC50 values of <0.00051, <0.00051, 0.00052 µM for EZH2 (Y641N), EZH2 (Y641F), EZH2 (wt), respectively. EZH2-IN-22 shows antiproliferation activity .
    EZH2-IN-22
  • HY-107769R
    Duocarmycin TM (Standard)

    CBI-TMI (Standard)

    		 Reference Standards ADC Payload DNA Alkylator/Crosslinker Antibiotic Cancer
    Duocarmycin TM (Standard) is the analytical standard of Duocarmycin TM (HY-107769). This product is intended for research and analytical applications. Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.
    Duocarmycin TM (Standard)
  • HY-185492
    MC-cBu-Cit-seco-CBI dimer

    		Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    MC-cBu-Cit-seco-CBI dimer (Compound 10) is a conjugate of an ADC drug toxin molecule and a linker, which consists of a DNA alkylating agent connected to a reactive maleimide via a protease-cleavable peptidomimetic linker .
    MC-cBu-Cit-seco-CBI dimer
  • HY-P11779
    Ac-RKAA-PABC-MMAE

    		Drug-Linker Conjugates for ADC Microtubule/Tubulin Cancer
    Ac-RKAA-PABC-MMAE is a Drug-Linker Conjugates for ADC. Ac-RKAA-PABC-MMAE consists of the ADC Cytotoxin MMAE (HY-15162) and a linker. Ac-RKAA-PABC-MMAE can be used for synthesis of ADCs .
    Ac-RKAA-PABC-MMAE
  • HY-182797
    NHWL071065

    		Molecular Glues IKZF Family IFNAR Cancer
    NHWL071065 is a CRBN-targeting IKZF1/IKZF3 molecular glues degrader. NHWL071065 selectively degrades IKZF1 and IKZF3 in lymphoma cells via the ubiquitin-proteasome pathway. NHWL071065 inhibits the proliferation of lymphoma cells. NHWL071065 downregulates proteins involved in cytoskeleton assembly, cell adhesion and immune regulation in cells, while upregulating proteins related to the type I IFN signaling pathway. NHWL071065 can be used in the research of lymphoma .
    NHWL071065

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