UBA6-IN-1
UBA6-IN-1 is a UBA6/UBE1L2 inhibitor (IC50 ≤50 nM) that acts by reducing the level of squalene epoxidase (SQLE). UBA6-IN-1 affects SREBP-dependent lipid metabolism processes and downstream cholesteryl ester transport, and can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1557137-61-7
- Formula: C20H21N5O4S
- Molecular Weight:427.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
UBA6-IN-1 (I-01) potently inhibits Uba6 enzyme activity, achieving 87% inhibition at 0.123 μM[1].
UBA6-IN-1 (10 μM; 6 h) alters SREBP-dependent lipid metabolism in WSU-DLCL2 cells when treated at 10 μM for 6 hours, as indicated by reduced SQLE protein levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1557137-61-7
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Molecular Weight 427.48
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Formula C20H21N5O4S
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SMILES
NS(OC[C@@H]1C[C@H](C[C@@H]1O)N2C3=NC=NC(C4=CC5=CC=CC=C5N4)=C3C=C2)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UBA6-IN-1 Related Classifications
HY-153774 Related Classifications
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