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Results for "

WT1

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

4

Peptides

1

Inhibitory Antibodies

8

Recombinant Proteins

10

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14872
    Tideglusib
    5+ Cited Publications

    NP031112

    		 GSK-3 Neurological Disease
    Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3β WT (1 h preincubation) and GSK-3β C199A (1 h preincubation), respectively.
    Tideglusib
  • HY-122913
    Borussertib

    		Akt Cancer
    Borussertib, a chemical probe, is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Akt wt .
    Borussertib
  • HY-P99650
    Grisnilimab

    WT1

    		 Transmembrane Glycoprotein Cancer
    Grisnilimab (WT1) is an IgG2a monoclonal antibody targeting CD7. Grisnilimab only binds to lymphoid tissues and T lymphocytes, with no off-target binding to normal tissues. Grisnilimab can be used to synthesize the immunotoxin WT1-SMPT-dgRTA, which exerts cytotoxic effects on T-lymphoblastic leukemia cells. Grisnilimab is applicable to relevant research on leukemia [1].
    Grisnilimab
  • HY-104036
    IDH-305
    4 Publications Verification

    		 Isocitrate Dehydrogenase (IDH) Cancer
    IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50= 27 nM (IDH1 R132H), 28 nM (IDH1 R132C), 6.14 µM (IDH1 WT)) .
    IDH-305
  • HY-RS17032
    Wt1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Wt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Wt1 Mouse Pre-designed siRNA Set A
    Wt1 Mouse Pre-designed siRNA Set A
  • HY-P11084
    WT1 126-134 peptide

    		MHC Inflammation/Immunology Cancer
    WT1 126-134 peptide is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL). WT1 126-134 peptide is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1). WT1 126-134 peptide can be used as a vaccine for T cells or as a target for antibodies [1] .
    WT1 126-134 peptide
  • HY-W143698
    PDGFRα kinase inhibitor 2

    		Bcr-Abl c-Kit PDGFR Cancer
    PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt .
    PDGFRα kinase inhibitor 2
  • HY-RS15853
    WT1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    WT1 Human Pre-designed siRNA Set A contains three designed siRNAs for WT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    WT1 Human Pre-designed siRNA Set A
    WT1 Human Pre-designed siRNA Set A
  • HY-P11084A
    WT1 126-134 peptide acetate

    		MHC Inflammation/Immunology Cancer
    WT1 126-134 peptide acetate is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL). WT1 126-134 peptide acetate is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide acetate/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1). WT1 126-134 peptide acetate can be used as a vaccine for T cells or as a target for antibodies [1] .
    WT1 126-134 peptide acetate
  • HY-RS23476
    Wt1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Wt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Wt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Wt1 Rat Pre-designed siRNA Set A
    Wt1 Rat Pre-designed siRNA Set A
  • HY-120765
    BRD2879

    		Isocitrate Dehydrogenase (IDH) Cancer
    BRD2879 is a potent IDH1-R132H inhibitor with IC50 values of 0.05, 2.5, >20, >20 µM for IDH1-R132H, IDH1-R132C, IDH1-WT, IDH2-R140Q, respectively. BRD2879 reduces (R)-2-hydroxyglutarate (R-2HG) levels [1].
    BRD2879
  • HY-104036R
    IDH-305 (Standard)

    		Reference Standards Isocitrate Dehydrogenase (IDH) Cancer
    IDH-305 (Standard) is the analytical standard of IDH-305 (HY-104036). This product is intended for research and analytical applications. IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50= 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (IDH1WT)) .
    IDH-305 (Standard)

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