PDGFRα kinase inhibitor 2
Based on 1 Customer Validation
PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt.
For research use only. We do not sell to patients.
- Purity: 98.95%
- CAS No.: 404844-11-7
- Formula: C24H20ClN5O
- Molecular Weight:429.90
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Abl1 6.95 μM (IC50) |
KIT 2.45 μM (IC50) |
PDGFR 1.39 μM (IC50) |
Chemical Information
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CAS No. 404844-11-7
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Appearance Solid
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Molecular Weight 429.90
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Formula C24H20ClN5O
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Color Off-white to light yellow
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SMILES
O=C(C1=CC=C(CCl)C=C1)NC2=CC=C(C)C(NC3=NC(C4=CN=CC=C4)=CC=N3)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 17.5 mg/mL (40.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3261 mL | 11.6306 mL | 23.2612 mL | 58.1531 mL |
| 5 mM | 0.4652 mL | 2.3261 mL | 4.6522 mL | 11.6306 mL | |
| 10 mM | 0.2326 mL | 1.1631 mL | 2.3261 mL | 5.8153 mL | |
| 15 mM | 0.1551 mL | 0.7754 mL | 1.5507 mL | 3.8769 mL | |
| 20 mM | 0.1163 mL | 0.5815 mL | 1.1631 mL | 2.9077 mL | |
| 25 mM | 0.0930 mL | 0.4652 mL | 0.9304 mL | 2.3261 mL | |
| 30 mM | 0.0775 mL | 0.3877 mL | 0.7754 mL | 1.9384 mL | |
| 40 mM | 0.0582 mL | 0.2908 mL | 0.5815 mL | 1.4538 mL |
PDGFRα kinase inhibitor 2 Related Classifications
HY-W143698 Related Classifications
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