2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl c-Kit PDGFR
  4. PDGFRα kinase inhibitor 2

PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt.

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PDGFRα kinase inhibitor 2

PDGFRα kinase inhibitor 2 Chemische Struktur

CAS. Nr. : 404844-11-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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PDGFRα kinase inhibitor 2 Related Antibodies

Top Publications Citing Use of Products

Alle Bcr-Abl Isoform-spezifische Produkte anzeigen:

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Abl Bcr-Abl

Alle PDGFR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
PDGFR PDGFRβ PDGFRα

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Beschreibung

PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt[1].

IC50 & Target[1]

Abl1

6.95 μM (IC50)

KIT

2.45 μM (IC50)

PDGFR

1.39 μM (IC50)

Molekulargewicht

429.90

Formel

C24H20ClN5O
CAS. Nr.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(CCl)C=C1)NC2=CC=C(C)C(NC3=NC(C4=CN=CC=C4)=CC=N3)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 17.5 mg/mL (40.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3261 mL 11.6306 mL 23.2612 mL
5 mM 0.4652 mL 2.3261 mL 4.6522 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 98.95%

SDS (393 KB)

COA (245 KB) HNMR (267 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3261 mL 11.6306 mL 23.2612 mL 58.1531 mL
5 mM 0.4652 mL 2.3261 mL 4.6522 mL 11.6306 mL
10 mM 0.2326 mL 1.1631 mL 2.3261 mL 5.8153 mL
15 mM 0.1551 mL 0.7754 mL 1.5507 mL 3.8769 mL
20 mM 0.1163 mL 0.5815 mL 1.1631 mL 2.9077 mL
25 mM 0.0930 mL 0.4652 mL 0.9304 mL 2.3261 mL
30 mM 0.0775 mL 0.3877 mL 0.7754 mL 1.9384 mL
40 mM 0.0582 mL 0.2908 mL 0.5815 mL 1.4538 mL
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PDGFRα kinase inhibitor 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDGFRα kinase inhibitor 2404844-11-7PDGFRα kinase inhibitor2PDGFRα kinase inhibitor-2Bcr-Ablc-KitPDGFRSCFRCD117Platelet-derived growth factor receptorCovalentirreversibleABL1KITPDGFRRInhibitorinhibitorinhibit

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