404844-11-7
404844-11-7
Chemical Structure
PDGFRα kinase inhibitor 2
- CAS No.: 404844-11-7
- Formula:C24H20ClN5O
- Molecular Weight:429.90
IUPAC Name: 4-(chloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
InChIKey: WUGWDFMSJPJUEZ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(CCl)C=C1)NC2=CC=C(C)C(NC3=NC(C4=CN=CC=C4)=CC=N3)=C2
Biological Activity: PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt[1].
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PDGFRα kinase inhibitor 2 | 98.95% | PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt. | ||||||||||||||||||||
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