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Cat. No.: HY-P99650

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Biologically Validated

Grisnilimab

(Synonyms: WT1)

Customer Review

Based on 1 Customer Validation

Grisnilimab (WT1) is an IgG2a monoclonal antibody targeting CD7. Grisnilimab only binds to lymphoid tissues and T lymphocytes, with no off-target binding to normal tissues. Grisnilimab can be used to synthesize the immunotoxin WT1-SMPT-dgRTA, which exerts cytotoxic effects on T-lymphoblastic leukemia cells. Grisnilimab is applicable to relevant research on leukemia.

For research use only. We do not sell to patients.

Purity: 99.43%
CAS No.: 2367001-70-3
Molecular Weight:146.39 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Grisnilimab Chemical Structure

CAS No.: 2367001-70-3

Size

Price

Stock

Quantity

Sample (0.1mg)

In-stock

(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Isotype

Mouse IgG2a

Recommend Isotype Controls

Mouse IgG2a kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CD7

In Vitro

Grisnilimab (2.5 μg/mL) specifically binds to human lymphoid tissues (T zone pattern) and scattered T lymphocytes, and shows no binding activity to other tested normal human tissues^[1].
Grisnilimab (3 μL of 1 mg/mL solution; 30 min) binds to the CD7 antigen on the surface of peripheral blood mononuclear cells from rhesus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

924 [NCBI]

Accession

P09564

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG2a-lambda

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Human CD7 Protein (His Tag) can bind Grisnilimab. The EC₅₀ for this effect is 22.65 ng/mL.

Chemical Information

CAS No. 2367001-70-3
Appearance Liquid
Molecular Weight 146.39 kDa
Color Colorless to light yellow
SMILES

[Grisnilimab]
Synonyms

WT1
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (256 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Hertler AA, et al. An immunotoxin for the treatment of T-acute lymphoblastic leukemic meningitis: studies in rhesus monkeys. Cancer Immunol Immunother. 1989;28(1):59-66. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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