CD7 - CD7 molecule Gene
Also Known as GP40; TP41; Tp40; LEU-9
Species: Homo sapiens
About CD7
This gene has 7 transcripts (splice variants) and 89 orthologues. Biased expression in spleen (RPKM 5.2), appendix (RPKM 4.1) and 12 other tissues.
Summary
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]
CD7 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_006137.7 | NP_006128.1 | T-cell antigen CD7 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
28514442 | GOA |
| enables transmembrane signaling receptor activity |
IDA
IDA: Inferred from direct assay
|
10652336 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of T cell cytokine production |
IDA
IDA: Inferred from direct assay
|
10652336 | GOA |
CD7 Protein Structure
V-set: Immunoglobulin V-set domain (27 - 131)
- 0
- 100
- 200
- 240 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
T-cell antigen CD7 |
|
CD7 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CD7 | P09564 | PTRH2 | Homo sapiens | Q9Y3E5 | 33961781 | |
|
Intra
|
CD7 | P09564 | PTRH2 | Homo sapiens | Q9Y3E5 | 28514442 | |
|
Intra
|
CD7 | P09564 | SEC22A | Homo sapiens | Q96IW7 | 32296183 |
Recombinant CD7 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70497 | CD7 Protein, Human (HEK293, His) | P09564 (A26-P180) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72361 | CD7 Protein, Human (Biotinylated, HEK293, His-Avi) | P09564 (A26-P180) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78414 | CD7 Protein, Human (HEK293, His-Avi) | P09564 (A26-P180) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P700854 | CD7 Protein, Human (HEK293, hFc) | P09564 (A26-P180) | ≥ 95%, as determined by reducing SDS-PAGE. |
CD7 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81660 | CD7 Antibody (YA1405) | WB, IHC-P, ICC/IF, FC | Human |
| HY-P81660A | CD7 Antibody (YA1405)(PBS only) | ||
| HY-P84029 | CD7 Antibody (YA3726) | IHC-P, FC, ELISA | Human |
| HY-P84029A | CD7 Antibody (YA3726)(PBS only) | IHC-P, FC, ELISA | Human |
| HY-P85897 | CD7 Antibody (YA5589) | IHC-P, WB, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Mycosis Fungoides |
|
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| Lymphoblastic Lymphoma |
|
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| Follicular Mucinosis |
|
|
| Mixed Phenotype Acute Leukemia, T/Myeloid |
|
|
| Sezary'S Disease |
|
|
| Strongyloidiasis |
|
|
| Parapsoriasis |
|
|
| Acute Leukemia |
|
|
| T-Cell Adult Acute Lymphocytic Leukemia |
|
|
| Aggressive Nk-Cell Leukemia |
|
|
| Primary Cutaneous Gamma-Delta T-Cell Lymphoma |
|
|
| Hepatosplenic T-Cell Lymphoma |
|
|
| Mature T-Cell And Nk-Cell Lymphoma |
|
|
| Rectum Lymphoma |
|
|
| Leukemia |
|
|
| Spongiotic Dermatitis |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| T-Cell Prolymphocytic Leukemia |
|
|
| Inflammatory Bowel Disease 16 |
|
|
| Acute Biphenotypic Leukemia |
|
|
| Breast Implant-Associated Anaplastic Large Cell Lymphoma |
|
|
| Adult Acute Lymphocytic Leukemia |
|
|
| Disseminated Eosinophilic Collagen Disease |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| T-Cell Large Granular Lymphocyte Leukemia |
|
|
| Lethal Midline Granuloma |
|
|
| B-Lymphoblastic Leukemia/Lymphoma With Hypodiploidy |
|
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| Adult T-Cell Leukemia/Lymphoma |
|
|
| Myeloproliferative Syndrome, Transient |
|
|
| Angioimmunoblastic T-Cell Lymphoma |
|
|
| Central Nervous System Leukemia |
|
|
| Chronic Nk-Cell Lymphocytosis |
|
|
| Myeloid Sarcoma |
|
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| Prolymphocytic Leukemia |
|
|
| Intrahepatic Bile Duct Adenoma |
|
|
| Mesothelioma, Malignant |
|
|
| Peripheral T-Cell Lymphoma |
|
|
| Childhood T-Cell Acute Lymphoblastic Leukemia |
|
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| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
|
| Paranasal Sinus Lymphoma |
|
|
| Precursor T-Cell Acute Lymphoblastic Leukemia |
|
|
| Anal Paget'S Disease |
|
|
| B-Lymphoblastic Leukemia/Lymphoma |
|
|
| Deficiency Anemia |
|
|
| Skin Disease |
|
|
| Acute Megakaryocytic Leukemia |
|
|
| Pancytopenia |
|
|
| Appendix Lymphoma |
|
|
| Leukemia, Acute Myeloid |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Celiac Disease 1 |
|
|
| Myelodysplastic Syndrome |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CD7 | MGD | MGI:88344 |
| Rattus norvegicus | CD7 | RGD | RGD:1310015 |
| Bos taurus | CD7 | VGNC | VGNC:27044 |
| Canis familiaris | CD7 | VGNC | VGNC:38969 |
| Macaca mulatta | CD7 | VGNC | VGNC:104593 |
| Felis catus | CD7 | VGNC | VGNC:98785 |
| Others | CD7 | NCBI |