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Borussertib 

Cat. No.: HY-122913
Handling Instructions

Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt.

For research use only. We do not sell to patients.

Borussertib Chemical Structure

Borussertib Chemical Structure

CAS No. : 1800070-77-2

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Description

Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1].

IC50 & Target[1]

Aktwt

0.8 nM (IC50)

Aktwt

2.2 nM (Ki)

In Vitro

Borussertib exhibits excellent cellular activity in the nanomolar range with superior profile against clinical candidate Akt inhibitors as well as the cytostatic drug doxorubicin. The EC50 values are 191±90 nM, 48±15 nM, 5±1 nM, 277±90 nM, 373±54 nM, 7770±641 nM in AN3CA (endometrium), T47D (breast), ZR-75-1 (breast), MCF-7 (breast), BT-474 (breast) and KU-19-19 (bladder) cell lines, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

596.68

Formula

C₃₆H₃₂N₆O₃

CAS No.

1800070-77-2

SMILES

C=CC(NC1=CC=C(N2)C(N(C3CCN(CC4=CC=C(C5=NC6=C(C(NC=C6)=O)C=C5C7=CC=CC=C7)C=C4)CC3)C2=O)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Borussertib
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Borussertib

Cat. No.: HY-122913