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Wd40

" in MedChemExpress (MCE) Product Catalog:

By Targets:	WDR5 (8) APC (1) Ligands for Target Protein for PROTAC (2) Mitosis (1) PROTACs (4)
By Research Areas:	Cancer (9)

Inhibitors & Agonists

Antibodies

Targets Recommended: WDR5

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110287

Apcin 5+ Cited Publications	APC Mitosis	Cancer
Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .

HY-141796

MS67	PROTACs WDR5	Cancer
MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a K_d of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects .

HY-141799

Dimethyl-F-OICR-9429-COOH	Ligands for Target Protein for PROTAC WDR5	Cancer
Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs .

HY-150403

XF067-68	PROTACs WDR5	Cancer
XF067-68 (example 132) is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5). XF067-68 can be usde for the study of WDR5-mediated diseases. (Pink: target protein ligand (HY-141799); Blue: E3 ligase ligand (HY-173627); Black: linker (HY-Y0966); E3 ligase ligand + linker: HY-176517) .

HY-141798

OICR-9429-N-C2-NH2	Ligands for Target Protein for PROTAC WDR5	Cancer
OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs .

HY-150400

XF056-132 free base	PROTACs WDR5	Cancer
XF056-132 free base is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader .

HY-159993

MR44397	WDR5	Cancer
MR44397 is a WD40 repeat (WDR) 5 ligand, can be used for cancer research .

HY-183959

DC_M5_2	WDR5	Cancer
DC_M5_2 is a WD40 repeat domain protein 5 (WDR5) inhibitor with an IC₅₀ of 9.63 μM and a K_D of 13.8 μM. DC_M5_2 binds to the WDR5 pocket that interacts with the MLL1 peptide, blocking the WDR5-MLL1 protein-protein interaction . DC_M5_2 can be used in leukemia-related research .

HY-169389

OICR41114	PROTACs WDR5	Cancer
OICR41114 is a WDR5 PROTAC degrader with an EC₅₀ of 40 nM. OICR41114 binds both DCAF1 and WDR5, and its binding affinity for DCAF1 is significantly enhanced in the presence of WDR5 (K_D increases from 59 nM to 5 nM). OICR41114 exerts antiproliferative effects on MV4-11 cells. OICR41114 can be used for the research of acute myeloid leukemia .

Host:	Mouse (2)
Reactivity:	Human (2) Rat (1) Mouse (1)
Application:	ICC/IF (2) IF-Tissue (1) IP (1) WB (2) ELISA (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85481

	WDR79 Antibody (YA5173) WRAP53; TCAB1; WdR79; Telomerase Cajal body protein 1; Wd repeat-containing protein 79; Wd40 repeat-containing protein encoding RNA antisense to p53	WB, ICC/IF, IP, ELISA, IF-Tissue	Human
	WDR79 Antibody (YA5173) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to WDR79.

HY-P85617

	RbBP5 Antibody (YA5309) RBBP 5; RBBP-5; RBBP5; RBBP5_HUMAN; RBQ 3; RBQ3; Retinoblastoma binding protein 5; Retinoblastoma binding protein RBQ3; Retinoblastoma binding protein5; Retinoblastoma-binding protein 5; Retinoblastoma-binding protein RBQ-3; SWd1; SWd1, Set1c Wd40 repeat protein, homolog.	WB, ICC/IF	Human, Mouse, Rat
	RbBP5 Antibody (YA5309) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to RbBP5.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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