WDR5 Protein, Human (sf9, His)
WDR5 Protein, Human (sf9, His) is the recombinant human-derived WDR5, expressed by Sf9 insect cells , with N-6*His labeled tag. ,
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
WDR5 Protein, Human (sf9, His) is the recombinant human-derived WDR5, expressed by Sf9 insect cells , with N-6*His labeled tag. ,
Background
WDR5 is a protein involved in histone modification, contributing to the positioning of the N-terminus of histone H3 for efficient trimethylation at Lys-4 (PubMed:16829960). As part of the MLL1/MLL complex, it participates in methylation and dimethylation of histone H3 at Lys-4 (PubMed:19556245), with H3 Lys-4 methylation serving as a specific tag for epigenetic transcriptional activation (PubMed:18840606). Within the NSL complex, it may be involved in the acetylation of nucleosomal histone H4 at multiple lysine residues (PubMed:19103755, PubMed:20018852). By similarity, it may regulate osteoblast differentiation. Additionally, in association with RBBP5 and ASH2L, WDR5 stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A, and SETD1B (PubMed:21220120, PubMed:22266653).
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-6*His
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Accession
P61964 (A2-C334)
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Gene ID11091
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Molecular Construction
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N-term
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6*His
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WDR5 (A2-C334)
Accession # P61964 -
C-term
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Protein Length
Full Length
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Synonyms
WDR5; WD Repeat Domain 5; CFAP89; BIG-3; SWD3; Cilia And Flagella Associated Protein 89; WD Repeat-Containing Protein 5; BMP2-Induced 3-Kb Gene Protein; BMP-2-Induced Gene 3 Kb; BIG3; SWD3, Set1c WD40 Repeat Protein, Homolog (S. Cerevisiae); SWD3, Set1c W
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AA Sequence
ATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
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Predicted Molecular Mass
37.5 kDa
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Molecular Weight
Approximately 38 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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