Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
XR
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "XR" in MCE Product Catalog:
57
57 Publications Verification
Synonyms: XR9576
Target:
Research Areas:
Tariquidar (XR9576) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM) .
57
57 Publications Verification
Synonyms: XR9576 methanesulfonate, hydrate
Target:
Research Areas:
Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of P-glycoprotein (P-gp) with a Kd of 5.1 nM.
2
2 Cited Publications
Target:
Research Areas:
AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of about 10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth .
XR8-89 is a potent papain-like protease (PL pro) inhibitor with an IC50 value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research .
Target:
Research Areas:
DACA (XR 5000) is a potential and blood-brain barrier-penetrating topoisomerase I and II inhibitor. DACA can be used in the research of colorectal cancer, leukemia and lung cancer .
Target:
Research Areas:
XR5944 is an anti-tumor compound with DNA-targeting activity. As a topoisomerase inhibitor, XR5944 can effectively inhibit the activities of topoisomerase I and II. XR5944 shows excellent anti-tumor activity against human and mouse tumor cells in vitro and in vivo. XR5944 exhibits significant potency in multiple cell lines, with IC50 values of 0.04-0.4 nM. XR5944 is not affected by atypical drug resistance in cells and remains significantly active even in cells overexpressing P-glycoprotein or multidrug resistance-related proteins. XR5944 showed anti-tumor efficacy in human tumor models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in most animals in the HT29 model. XR5944 can be used to study biological processes related to colon and lung cancer .
Cat. No.: HY-10550R
CAS No.: 206873-63-4
Synonyms: XR9576 (Standard)
Target:
Research Areas:
Tariquidar (Standard) is the analytical standard of Tariquidar. This product is intended for research and analytical applications. Tariquidar (XR9576) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM) .
Cat. No.: HY-110377
CAS No.: 1992047-62-7
Synonyms: XR9576 dihydrochloride
Target:
Research Areas:
Tariquidar dihydrochloride (XR9576 dihydrochloride) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM) .
Cat. No.: HY-125669
CAS No.: 247090-97-7
Target:
Research Areas:
XR 3054 is an inhibitor for Farnesyl Transferase, that inhibits farnesylation of CAAX recognition peptide with IC50 of 50 μM. XR 3054 suppresses the farnesylation of p21 ras and activation of MAP kinase. XR 3054 inhibits the proliferation of prostate cancer cell and colon cancer cell, with IC50 of 8.8-21.4 μM .
Synonyms: XR-543
Target:
Research Areas:
DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer .
Cat. No.: HY-10550B
CAS No.: 625375-84-0
Synonyms: XR9576 dimesylate
Target:
Research Areas:
Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (P-gp) inhibitor. Tariquidar dimesylate increases the concentration of the drug in the brain by binding to P-glycoprotein, preventing it from transporting the drug from inside to outside the brain. Tariquidar dimesylate can be used in the study of blood-brain barrier penetration and multidrug resistance .
Cat. No.: HY-117537
CAS No.: 174766-49-5
Target:
Research Areas:
XR 5118 hydrochloride is an inhibitor of plasminogen activator inhibitor 1 (PAI-1) (IC50: 12 µM). XR5118 binds to PAI-1 and reduces plasma PAI-1 activity levels. XR5118 hydrochloride promotes endogenous thrombolysis and inhibits thrombus accretion. XR 5118 hydrochloride can be used for research of cancer and thrombotic disease .
Cat. No.: HY-123143
CAS No.: 346689-77-8
Synonyms: MLN576
Target:
Research Areas:
XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC50: 6-47 nM) .
Cat. No.: HY-13776
CAS No.: 762219-35-2
Target:
Research Areas:
XR9051 is an orally active and specific modulator of P-glycoprotein-mediated multidrug resistance (MDR) .
Cat. No.: HY-13776A
CAS No.: 180422-22-4
Target:
Research Areas:
XR9051 hydrochloride is an orally active and specific modulator of P-glycoprotein-mediated multidrug resistance (MDR) .
Cat. No.: HY-RS14262
Target:
Research Areas:
TBL1XR1 Human Pre-designed siRNA Set A contains three designed siRNAs for TBL1XR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20223
Target:
Research Areas:
Tbl1xr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tbl1xr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26730
Target:
Research Areas:
Tbl1xr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tbl1xr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS03602
Target:
Research Areas:
DCXR Human Pre-designed siRNA Set A contains three designed siRNAs for DCXR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
