2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. XR9051 hydrochloride

XR9051 hydrochloride is an orally active and specific modulator of P-glycoprotein-mediated multidrug resistance (MDR).

For research use only. We do not sell to patients.

XR9051 hydrochloride Chemical Structure

XR9051 hydrochloride Chemical Structure

CAS No. : 180422-22-4

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XR9051 hydrochloride Related Antibodies

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Description

XR9051 hydrochloride is an orally active and specific modulator of P-glycoprotein-mediated multidrug resistance (MDR)[1].

In Vitro

XR9051 is able to reverse resistance to a variety of cytotoxic drugs, including doxorubicin, etoposide and vincristine, which are associated with classical MDR[1].
XR9051 is highly active and gave at least a 15- to 20- fold decrease in the doxorubicin IC50, in the acquired resistance cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XR9051 hydrochloride Related Antibodies
In Vivo

XR9051 (20-40 mg/kg, ip) shows significant modulatory activity in mice bearing MDR human ovarian (2780AD and CH1/DOXr) and SCLC (H69/LX) xenografts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice (20-25 g)[2].
Dosage: I.V.
Administration: 20 mg/kg at various times (5 min to 24 h).
Result: The area under the concentration time curves (AUC) from time 0-∞ for plasma was 11.9 µg. h mL-1. The ratio between AUC for tissue:plasma for liver, heart and brain were 79.6, 16.9 and 0.3 respectively.
Animal Model: MDR 2780AD ovarian carcinoma xenografts[2].
Dosage: I.P.
Administration: 20, 30, 40 mg/kg daily with Epirubicin i.v. (10 mg/kg).
Result: Significantly reduced growth rate of MDR 2780AD ovarian carcinoma xenografts compared with either drug alone.
Molecular Weight

679.20

Formula

C39H39ClN4O5
CAS No.
SMILES

O=C(NC1=CC=C(CCN2CC3=C(C=C(OC)C(OC)=C3)CC2)C=C1)C4=CC=CC(/C=C(C(N(C)/C5=C\C6=CC=CC=C6)=O)\NC5=O)=C4.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XR9051 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XR9051180422-22-4XR 9051XR-9051P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243P-gtycoproteinmultidrug resistanceMDRovarian cancercolon carcinoma leukaemiaInhibitorinhibitorinhibit

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XR9051 hydrochloride
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