174766-49-5
Chemical Structure
XR 5118 hydrochloride
- CAS No.: 174766-49-5
- Formula:C20H22ClN3O2S2
- Molecular Weight:435.99
IUPAC Name: (Z)-3-((Z)-benzylidene)-6-((5-((2-(dimethylamino)ethyl)thio)thiophen-2-yl)methylene)piperazine-2,5-dione hydrochloride
InChIKey: RNEFNOPEPDWDPT-GZLFPKDFSA-N
SMILES: O=C(/C(NC/1=O)=C/C2=CC=C(SCCN(C)C)S2)NC1=C/C3=CC=CC=C3.Cl
Biological Activity: XR 5118 hydrochloride is an inhibitor of plasminogen activator inhibitor 1 (PAI-1) (IC50: 12 µM). XR5118 binds to PAI-1 and reduces plasma PAI-1 activity levels. XR5118 hydrochloride promotes endogenous thrombolysis and inhibits thrombus accretion. XR 5118 hydrochloride can be used for research of cancer and thrombotic disease[1][2].
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XR 5118 hydrochloride | XR 5118 hydrochloride is an inhibitor of plasminogen activator inhibitor 1 (PAI-1) (IC50: 12 µM). XR5118 binds to PAI-1 and reduces plasma PAI-1 activity levels. XR5118 hydrochloride promotes endogenous thrombolysis and inhibits thrombus accretion. XR 5118 hydrochloride can be used for research of cancer and thrombotic disease. | |||||||||||||||||||||
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- [1]. Friederich PW,et al. Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits. Circulation. 1997 Aug 5;96(3):916-21. [Content Brief]
- [2]. Einholm AP, et al. Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1. Biochem J. 2003 Aug 1;373(Pt 3):723-32. [Content Brief]
Keywords
