XR 5118 hydrochloride

Cat. No.: HY-117537: Ficha de datos Instrucciones de manejo
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XR 5118 hydrochloride is an inhibitor of plasminogen activator inhibitor 1 (PAI-1) (IC₅₀: 12 µM). XR5118 binds to PAI-1 and reduces plasma PAI-1 activity levels. XR5118 hydrochloride promotes endogenous thrombolysis and inhibits thrombus accretion. XR 5118 hydrochloride can be used for research of cancer and thrombotic disease.

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XR 5118 hydrochloride Estructura química

No. CAS : 174766-49-5

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Descripciòn	XR 5118 hydrochloride is an inhibitor of plasminogen activator inhibitor 1 (PAI-1) (IC₅₀: 12 µM). XR5118 binds to PAI-1 and reduces plasma PAI-1 activity levels. XR5118 hydrochloride promotes endogenous thrombolysis and inhibits thrombus accretion. XR 5118 hydrochloride can be used for research of cancer and thrombotic disease^[1]^[2].
Peso molecular	435.99
Fòrmula	C₂₀H₂₂ClN₃O₂S₂
No. CAS	174766-49-5
SMILES	O=C(/C(NC/1=O)=C/C2=CC=C(SCCN(C)C)S2)NC1=C/C3=CC=CC=C3.Cl
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (268 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Friederich PW,et al. Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits. Circulation. 1997 Aug 5;96(3):916-21. [Content Brief] [2]. Einholm AP, et al. Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1. Biochem J. 2003 Aug 1;373(Pt 3):723-32. [Content Brief]