XR 5118 hydrochloride
XR 5118 hydrochloride is an inhibitor of plasminogen activator inhibitor 1 (PAI-1) (IC50: 12 µM). XR5118 binds to PAI-1 and reduces plasma PAI-1 activity levels. XR5118 hydrochloride promotes endogenous thrombolysis and inhibits thrombus accretion. XR 5118 hydrochloride can be used for research of cancer and thrombotic disease.
For research use only. We do not sell to patients.
- CAS No.: 174766-49-5
- Formula: C20H22ClN3O2S2
- Molecular Weight:435.99
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 174766-49-5
-
Molecular Weight 435.99
-
Formula C20H22ClN3O2S2
-
SMILES
O=C(/C(NC/1=O)=C/C2=CC=C(SCCN(C)C)S2)NC1=C/C3=CC=CC=C3.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Friederich PW,et al. Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits. Circulation. 1997 Aug 5;96(3):916-21. [Content Brief]
[2]. Einholm AP, et al. Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1. Biochem J. 2003 Aug 1;373(Pt 3):723-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XR 5118 hydrochloride Related Classifications
HY-117537 Related Classifications
Powered by Bioz