2. Anti-infection
  3. SARS-CoV
  4. XR8-89

XR8-89 is a potent papain-like protease (PLpro) inhibitor with an IC50 value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research.

For research use only. We do not sell to patients.

XR8-89 Chemical Structure

XR8-89 Chemical Structure

CAS No. : 2817811-16-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 444 In-stock
Solution
10 mM * 1 mL in DMSO USD 444 In-stock
Solid
5 mg USD 400 In-stock
10 mg USD 680 In-stock
25 mg USD 1350 In-stock
50 mg USD 2200 In-stock
100 mg USD 3400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

XR8-89 Related Antibodies

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  • Purity & Documentation

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Description

XR8-89 is a potent papain-like protease (PLpro) inhibitor with an IC50 value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research[1].

IC50 & Target

IC50: 0.1 μM (papain-like protease)[1]
In Vitro

XR8-89 induces conformational changes manly in BL2 region and increases the activity against PLpro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XR8-89 Related Antibodies
Molecular Weight

504.69

Formula

C29H36N4O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=CC=C(NC2CNC2)C=C1C(N[C@H](C)C3=CC=CC(C4=CC=C(S4)CN[C@@H]5C[C@H](O)CC5)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (99.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9814 mL 9.9071 mL 19.8141 mL
5 mM 0.3963 mL 1.9814 mL 3.9628 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9814 mL 9.9071 mL 19.8141 mL 49.5354 mL
5 mM 0.3963 mL 1.9814 mL 3.9628 mL 9.9071 mL
10 mM 0.1981 mL 0.9907 mL 1.9814 mL 4.9535 mL
15 mM 0.1321 mL 0.6605 mL 1.3209 mL 3.3024 mL
20 mM 0.0991 mL 0.4954 mL 0.9907 mL 2.4768 mL
25 mM 0.0793 mL 0.3963 mL 0.7926 mL 1.9814 mL
30 mM 0.0660 mL 0.3302 mL 0.6605 mL 1.6512 mL
40 mM 0.0495 mL 0.2477 mL 0.4954 mL 1.2384 mL
50 mM 0.0396 mL 0.1981 mL 0.3963 mL 0.9907 mL
60 mM 0.0330 mL 0.1651 mL 0.3302 mL 0.8256 mL
80 mM 0.0248 mL 0.1238 mL 0.2477 mL 0.6192 mL
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XR8-89 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XR8-892817811-16-6SARS-CoVSARS coronaviruspapain-like proteaseSARS-CoV-2conformationalInhibitorinhibitorinhibit

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