2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. Tariquidar dimesylate

Tariquidar dimesylate  (Synonyms: XR9576 dimesylate)

Cat. No.: HY-10550B
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Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (P-gp) inhibitor. Tariquidar dimesylate increases the concentration of the drug in the brain by binding to P-glycoprotein, preventing it from transporting the drug from inside to outside the brain. Tariquidar dimesylate can be used in the study of blood-brain barrier penetration and multidrug resistance.

For research use only. We do not sell to patients.

CAS No. : 625375-84-0

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Tariquidar dimesylate Related Antibodies

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56 Publications Citing Use of MCE Tariquidar dimesylate

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Cell Imaging/Staining
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    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Cell. 2023 Dec 7;186(25):5500-5516.e21.  [Abstract]

    Survival curves of mice under SD (SR means 48 h of recovery after SD) with i.p. administration of tariquidar (n = 5) or vehicle (n = 5).

    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2021 Aug 5;7(1):204.  [Abstract]

    MCF-7ADR cells were treated with ADR (2μM) alone or together with Tariquidar (TQ; 0.5 μM) for 48h. Cell viability was detected using the CCK8 assays.

    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2021 Jun 11;10(6):949.  [Abstract]

    Tariquidar (1.5 μM; 72 h). Western blotting results show the specific inhibition of both MRP1/ABCC1 and MDR1/ABCB1 after tariquidar treatment for 72 h in both control and DEHP-exposed MDA-MB-231 clones.

    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2021 Jun 11;10(6):949.  [Abstract]

    Tariquidar (1.5 μM; 2 h). Enhanced Dox accumulation was observed following 2 h of Tariquidar pretreatment in DEHP-exposed MDA-MB-231 clones #1 and #2, analyzed by a BD Accuri TW C6 flow cytometer.

    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Small. 2020 Nov;16(44):e2004172.  [Abstract]

    In vitro tumor penetration of the DOX-loaded liposomes in BxPC3 MTS. The BxPC3 MTS were prestained with or without a Pg-p inhibitor Tariquidar (10 nM) for 3 h. Subsequently, the MTS were cultured with DOX-loaded liposomes for 6 h. The MTS were visualized using CLSM in Z-stacks with 25 µm intervals. DOX (red).

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    Description

    Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (P-gp) inhibitor. Tariquidar dimesylate increases the concentration of the drug in the brain by binding to P-glycoprotein, preventing it from transporting the drug from inside to outside the brain. Tariquidar dimesylate can be used in the study of blood-brain barrier penetration and multidrug resistance[1].

    Clinical Trial
    Molecular Weight

    838.94

    Formula

    C40H46N4O12S2
    CAS No.
    SMILES

    O=C(NC1=CC(OC)=C(C=C1C(NC2=CC=C(C=C2)CCN3CC4=C(CC3)C=C(C(OC)=C4)OC)=O)OC)C5=CC6=CC=CC=C6N=C5.OS(=O)(C)=O.OS(=O)(C)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Tariquidar dimesylate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tariquidar dimesylate625375-84-0XR9576 dimesylateP-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Blood-brain barrierMultidrug resistanceInhibitorinhibitorinhibit

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