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Results for "

atrial

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adenosine Receptor (6) Adrenergic Receptor (16) Akt (1) Amyloid-β (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (5) Apoptosis (4) Autophagy (4) Biochemical Assay Reagents (2) Calcium Channel (16) Calmodulin (3) Carbonic Anhydrase (4) Claudin (1) COX (1) Cytochrome P450 (4) Drug Derivative (3) Drug Intermediate (1) Drug Metabolite (3) Endogenous Metabolite (4) Endothelin Receptor (8) ERK (1) Factor Xa (2) Fluorescent Dye (2) Gap Junction Protein (2) Guanylate Cyclase (3) Histamine Receptor (1) Histone Methyltransferase (1) Interleukin Related (2) Isotope-Labeled Compounds (8) JAK (1) JNK (1) mAChR (11) MMP (1) Monoamine Oxidase (2) Na+/K+ ATPase (3) Natriuretic Peptide Receptor (NPR) (10) Neprilysin (7) NF-κB (2) NO Synthase (1) NOD-like Receptor (NLR) (2) P-glycoprotein (1) p38 MAPK (1) Phosphodiesterase (PDE) (2) PI3K (1) PKA (1) PKC (1) PKG (3) Potassium Channel (52) Prolyl Endopeptidase (PREP) (2) Reactive Oxygen Species (ROS) (1) Reference Standards (18) Ser/Thr Protease (1) Sodium Channel (32) Thrombin (6) Transthyretin (TTR) (1) α-synuclein (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (144) Endocrinology (10) Infection (1) Inflammation/Immunology (19) Metabolic Disease (17) Neurological Disease (19)

By Targets:

5-HT Receptor (2)

Adenosine Receptor (6)

Adrenergic Receptor (16)

Akt (1)

Amyloid-β (1)

Androgen Receptor (1)

Angiotensin-converting Enzyme (ACE) (5)

Apoptosis (4)

Autophagy (4)

Biochemical Assay Reagents (2)

Calcium Channel (16)

Calmodulin (3)

Carbonic Anhydrase (4)

Claudin (1)

COX (1)

Cytochrome P450 (4)

Drug Derivative (3)

Drug Intermediate (1)

Drug Metabolite (3)

Endogenous Metabolite (4)

Endothelin Receptor (8)

ERK (1)

Factor Xa (2)

Fluorescent Dye (2)

Gap Junction Protein (2)

Guanylate Cyclase (3)

Histamine Receptor (1)

Histone Methyltransferase (1)

Interleukin Related (2)

Isotope-Labeled Compounds (8)

JAK (1)

JNK (1)

mAChR (11)

MMP (1)

Monoamine Oxidase (2)

Na+/K+ ATPase (3)

Natriuretic Peptide Receptor (NPR) (10)

Neprilysin (7)

NF-κB (2)

NO Synthase (1)

NOD-like Receptor (NLR) (2)

P-glycoprotein (1)

p38 MAPK (1)

Phosphodiesterase (PDE) (2)

PI3K (1)

PKA (1)

PKC (1)

PKG (3)

Potassium Channel (52)

Prolyl Endopeptidase (PREP) (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (18)

Ser/Thr Protease (1)

Sodium Channel (32)

Thrombin (6)

Transthyretin (TTR) (1)

α-synuclein (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (144)

Endocrinology (10)

Infection (1)

Inflammation/Immunology (19)

Metabolic Disease (17)

Neurological Disease (19)

167

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0016

Dronedarone 4 Publications Verification SR 33589	mAChR Sodium Channel Calcium Channel Adrenergic Receptor Cytochrome P450 Autophagy	Cardiovascular Disease
Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4 .

HY-10274

Dabigatran etexilate 4 Publications Verification BIBR 1048	Thrombin	Cardiovascular Disease
Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation .

HY-B0588

Brinzolamide Maximum Cited Publications 7 Publications Verification AL-4862	Carbonic Anhydrase	Cardiovascular Disease Others Neurological Disease
Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research .

HY-B0432A

Propafenone hydrochloride 2 Publications Verification SA-79 hydrochloride	Sodium Channel	Cardiovascular Disease
Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

HY-P1235A

Carperitide acetate 3 Publications Verification atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.

HY-P1236

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse atrial natriuretic factor (1-28) (rat, mouse)	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

HY-103175

PSB36 1 Publications Verification	Adenosine Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
PSB36 is a highly selective A₁ adenosine receptor antagonist, with a K_i of 0.12 nM and a K_d of 0.7 nM. Systemic administration of PSB36 reduces formalin- and Carrageenan (HY-125474)-induced edema in mice and decreases pain-related behaviors, with no local paw activity. PSB36 prolongs the APD₉₀ of rat and human atria, produces a frequency-dependent prolongation of rat atrial ERP, increases the diastolic threshold of rat atria, and shortens the duration of atrial fibrillation episodes. PSB36 can be used in research related to inflammatory pain, inflammatory hyperalgesia, edema and atrial fibrillation .

HY-P1419

AP 811	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K_i of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation .

HY-12533

Disopyramide 2 Publications Verification Dicorantil; SC-7031	Sodium Channel Potassium Channel	Cardiovascular Disease
Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action .

HY-106225

Rotigaptide 1 Publications Verification ZP123	Gap Junction Protein	Cardiovascular Disease
Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically atrial fibrillation .

HY-16738A

Eleclazine hydrochloride 2 Publications Verification GS 6615 hydrochloride	Sodium Channel Potassium Channel	Cardiovascular Disease
Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC₅₀ value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias .

HY-12533A

Disopyramide phosphate 2 Publications Verification Dicorantil phosphate; SC-7031 phosphate	Potassium Channel Sodium Channel	Cardiovascular Disease
Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action .

HY-10274A

Dabigatran etexilate mesylate 4 Publications Verification BIBR 1048MS; Dabigatran etexilate methanesulfonate	Thrombin	Cardiovascular Disease
Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation .

HY-34350

2-(Aminomethyl)phenol 2-Hydroxybenzylamine; o-Hydroxybenzylamine; 2-HOBA	Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology
2-(Aminomethyl)phenol (2-Hydroxybenzylamine) is a selective dicarbonyl scavenger. 2-(Aminomethyl)phenol is an antioxidant and scavanger of free radicals and isolevuglandins (IsoLGs). 2-(Aminomethyl)phenol can prevent early recurrence of atrial fibrillation. 2-(Aminomethyl)phenol can reduce inflammation and plaque apoptotic cells and promote efferocytosis and features of stable plaques. 2-(Aminomethyl)phenol can reduce malondialdehyde (MDA)-LDL and MDA-HDL levels in Ldlr ^-/- mouse model. 2-(Aminomethyl)phenol can be studied in the research of inflammation and cardiovascular disease, such as atherosclerosis, early recurrence of atrial fibrillation (AF) and arrhythmias .

HY-136933

Gitoxin	Na+/K+ ATPase	Cardiovascular Disease
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure .

HY-17494

Timolol (S)-L-714,465; MK 950 free base	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .

HY-100712

DPO-1 1 Publications Verification	Potassium Channel Calcium Channel NOD-like Receptor (NLR) Interleukin Related	Cardiovascular Disease Inflammation/Immunology
DPO-1 is a potent Kv1.5 and Kv1.3 (EC₅₀ = 3.1 μM) channels inhibitor with potential immunomodulatory and anti-inflammatory effects. DPO-1 reduces Kv1.3 current density, blunts Ca ²⁺ influx in Ca ²⁺-depleted Jurkat cells, and inhibits IL-2 secretion in activated Jurkat cells. DPO-1 inhibits Uric acid sodium (HY-B2130A) (MSU)-induced NLRP3 inflammasome activation by blocking Kv1.5-mediated K ⁺ efflux. DPO-1 can be used for the study of immunologic disorders and atrial fibrillation .

HY-119124

Edoxaban M4 D21-2393	Factor Xa	Cardiovascular Disease Inflammation/Immunology
Edoxaban M4 (D21-2393) is an orally active and selective Factor Xa inhibitor with a human Factor Xa IC₅₀ of 1.8 nM. Edoxaban M4 exhibits anticoagulant activity via Factor Xa inhibition. Edoxaban M4 can be used for the research of non-valvular atrial fibrillation, venous thromboembolisms, pulmonary embolism .

HY-P1236A

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA atrial natriuretic factor (1-28) (rat, mouse) TFA	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

HY-157557

AP30663	Potassium Channel	Cardiovascular Disease
AP30663 is a KCa2 channel inhibitor that can be used for the study of atrial fibrillation .

HY-N5016

Guvacoline hydrochloride	mAChR	Cardiovascular Disease
Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors .

HY-P1526

ANP [Des18-22] 4-23 amide (rat)	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C .

HY-P1604

ATX-II 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-P1604A

ATX-II TFA 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II TFA is a selective sodium channel modulator toxin. ATX-II TFA enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II TFA has pro-arrhythmic effect. ATX-II TFA slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II TFA can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-P2281A

Atrial natriuretic factor (1-28) (human, porcine) TFA 1 Publications Verification atrial natriuretic peptide (1-28) TFA	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Atrial natriuretic factor (1-28) (human, porcine) TFA exhibits blood pressure lowering activity by increasing sodium and urine excretion. Atrial natriuretic factor (1-28) (human, porcine) TFA inhibits the release of pituitary adrenocorticotropic hormone (ACTH) and beta-endorphin through inhibition of pro-opiomelanocortin (POMC) expression. Atrial natriuretic factor (1-28) (human, porcine) TFA increases cGMP levels in RMIC cells with an IC₅₀ of 1.2 nM .

HY-P5792

Atrial natriuretic peptide (3-28) (human) ANP (3-28) (human)	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) is a peptide hormone that is synthesized and secreted by the atrial myocardium. Atrial natriuretic peptide (3-28) (human) is involved in the regulation of blood pressure, fluid balance, and electrolyte homeostasis .

HY-P2491

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled	Fluorescent Dye	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriuretic peptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide has the potential for cardiovascular diseases research .

HY-116490

Guvacoline hydrobromide	mAChR	Cardiovascular Disease
Guvacoline hydrobromide, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal mAChR .

HY-108579

UCL 1684 dibromide	Potassium Channel	Cardiovascular Disease
UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of I_Na. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness .

HY-A0236

Aprindine	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine is an Ib-class anti-arrhythmic agent. Aprindine mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-P1235

Carperitide atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.

HY-100795A

Pirmenol hydrochloride (±)-Pirmenol hydrochloride; CI-845	mAChR Potassium Channel	Cardiovascular Disease
Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits I_K.ACh (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation .

HY-W002450

L-Cyclohexylalanine	Drug Derivative	Cardiovascular Disease
L-Cyclohexylalanine is an amino acid derivative. L-Cyclohexylalanine modifies an atrial natriuretic peptide, regulates homeostasis of body fluid and blood pressure homeostasis and vasodilation activity .

HY-122033

MK-0448	Potassium Channel	Cardiovascular Disease
MK-0448 is a specific Kv1.5 inhibitor used in the research of atrial fibrillation .

HY-A0236A

Aprindine hydrochloride	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-P3763

Atrial Natriuretic Peptide (7-28), human, canine	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Atrial Natriuretic Peptide (7-28), human, canine is a peptide fragment of atrial natriuretic peptide, can be used as a peptide tag .

HY-118387

AVE-0118	Potassium Channel	Cardiovascular Disease
AVE-0118 is a Kv1.5 potassium channel blocker and antiarrhythmic agent. AVE-0118 blocks neuronal Kv1.5 potassium channels, thereby enhancing the release of norepinephrine. AVE-0118 enhances field stimulation-induced neurogenic contraction, an effect sensitive to α1-adrenergic receptor blockade. AVE-0118 terminates persistent atrial fibrillation in some dogs. AVE-0118 is applicable to research related to atrial fibrillation and persistent atrial fibrillation .

HY-P3758

BNP (1-21), Pro (Human)	Natriuretic Peptide Receptor (NPR)	Others
BNP (1-21), Pro (Human) is a peptide containg 21 amino acids. B-Type Natriuretic Peptide (BNP), a cardiac natriuretic hormone. BNP together with the highly homologous atrial natriuretic peptide, it forms a dual natriuretic peptide system of the heart. BNP is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life .

HY-B0588A

Brinzolamide hydrochloride AL-4862 hydrochloride	Carbonic Anhydrase	Neurological Disease
Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research .

HY-10274R

Dabigatran etexilate (Standard) BIBR 1048 (Standard)	Reference Standards Thrombin	Cardiovascular Disease
Dabigatran etexilate (Standard) is the analytical standard of Dabigatran etexilate. This product is intended for research and analytical applications. Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation .

HY-P3772

[Mpr7, DAla9] ANP (7-28), amide, rat	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
[Mpr7, DAla9] ANP (7-28), amide, rat is an atrial peptide .

HY-16738

Eleclazine 2 Publications Verification GS-6615	Sodium Channel Potassium Channel	Cardiovascular Disease
Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC₅₀ of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias .

HY-U00171

SQ28603 SQ28,603; Squibb 28603	Neprilysin	Metabolic Disease
SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).

HY-P3762

ANP (1-30), frog	Endothelin Receptor	Cardiovascular Disease Endocrinology
ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide derived from frog. ANP (1-30), frog has natriuretic, diuretic, and vasorelaxant effects.

HY-100795

Pirmenol (±)-Pirmenol; CI-845 free base	mAChR Potassium Channel	Cardiovascular Disease
Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits I_K.ACh (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation .

HY-123793

MK-1832	Potassium Channel P-glycoprotein	Cardiovascular Disease
MK-1832 (Compound 32) is a selective Kv1.5 inhibitor (IC₅₀ = 86 nM). MK-1832 is a P-glycoprotein substrate. MK-1832 can be used in atrial fibrillation research .

HY-14834

Budiodarone ATI-2042	Potassium Channel Sodium Channel Calcium Channel	Cardiovascular Disease
Budiodarone (ATI-2042) is an analogue of Amiodarone (HY-14187) with a half-life of 7 h. Budiodarone inhibits sodium, potassium, and calcium ion channels. Budiodarone is an antiarrhythmic agent and can be used for the research of atrial fibrillation .

HY-P10259

BNP(1-32), porcine pBNP-32	Natriuretic Peptide Receptor (NPR)	Neurological Disease
BNP(1-32), porcine (pBNP-32) is a cardiac hormone. BNP(1-32), porcine is an atrial natriuretic peptide, which exhibits natriuretic, diuretic and vasorelaxant effects. BNP(1-32), porcine affects passive avoidance learning in rats with dopaminergic, cholinergic, α-and β-adrenergic mediation .

HY-106225R

Rotigaptide (Standard) ZP123 (Standard)	Reference Standards Gap Junction Protein	Cardiovascular Disease
Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation .

HY-14182

Vernakalant RSD1235	Potassium Channel	Cardiovascular Disease
Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.

Cat. No.	Product Name	Target	Research Area

HY-P1235A

Carperitide acetate 3 Publications Verification atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.

HY-P1236

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse atrial natriuretic factor (1-28) (rat, mouse)	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

HY-P1419

AP 811	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K_i of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation .

HY-P1236A

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA atrial natriuretic factor (1-28) (rat, mouse) TFA	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

HY-P1526

ANP [Des18-22] 4-23 amide (rat)	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C .

HY-P1604

ATX-II 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-P1604A

ATX-II TFA 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II TFA is a selective sodium channel modulator toxin. ATX-II TFA enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II TFA has pro-arrhythmic effect. ATX-II TFA slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II TFA can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-P2281A

Atrial natriuretic factor (1-28) (human, porcine) TFA 1 Publications Verification atrial natriuretic peptide (1-28) TFA	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Atrial natriuretic factor (1-28) (human, porcine) TFA exhibits blood pressure lowering activity by increasing sodium and urine excretion. Atrial natriuretic factor (1-28) (human, porcine) TFA inhibits the release of pituitary adrenocorticotropic hormone (ACTH) and beta-endorphin through inhibition of pro-opiomelanocortin (POMC) expression. Atrial natriuretic factor (1-28) (human, porcine) TFA increases cGMP levels in RMIC cells with an IC₅₀ of 1.2 nM .

HY-P4811

*Prepro-Atrial* Natriuretic Factor (26-55) (human)**	Peptides	Metabolic Disease
Prepro-Atrial Natriuretic Factor (26-55) (human) is a polypeptide that increases renal cortical and medullary cyclic GMP levels. Prepro-Atrial Natriuretic Factor (26-55) (human) increases renal guanylate cyclase activity .

HY-P5792

Atrial natriuretic peptide (3-28) (human) ANP (3-28) (human)	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) is a peptide hormone that is synthesized and secreted by the atrial myocardium. Atrial natriuretic peptide (3-28) (human) is involved in the regulation of blood pressure, fluid balance, and electrolyte homeostasis .

HY-P2491

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled	Fluorescent Dye	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriuretic peptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide has the potential for cardiovascular diseases research .

HY-P3769

Prepro-ANF (56-92), human	Guanylate Cyclase	Cardiovascular Disease
Prepro-ANF (56-92), human is a human atrial natriuretic factor precursor. Prepro-ANF (56-92), human is also a guanylate cyclase activator that enhances particulate guanylate cyclase activity in the renal membrane and renal unit .

HY-P1235

Carperitide atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.

HY-W002450

L-Cyclohexylalanine	Drug Derivative	Cardiovascular Disease
L-Cyclohexylalanine is an amino acid derivative. L-Cyclohexylalanine modifies an atrial natriuretic peptide, regulates homeostasis of body fluid and blood pressure homeostasis and vasodilation activity .

HY-P3763

Atrial Natriuretic Peptide (7-28), human, canine	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Atrial Natriuretic Peptide (7-28), human, canine is a peptide fragment of atrial natriuretic peptide, can be used as a peptide tag .

HY-P4906

Atrial Natriuretic Factor (5-27) (human)	Peptides	Others
Atrial Natriuretic Factor (5-27) (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3765

Auriculin A	Peptides	Cardiovascular Disease
Auriculin A is a synthetic atrial natriuretic factor (ANF) with hemodynamic effect. Auriculin A antagonizes renal vasoconstriction in the dog, and influences on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits .

HY-P3758

BNP (1-21), Pro (Human)	Natriuretic Peptide Receptor (NPR)	Others
BNP (1-21), Pro (Human) is a peptide containg 21 amino acids. B-Type Natriuretic Peptide (BNP), a cardiac natriuretic hormone. BNP together with the highly homologous atrial natriuretic peptide, it forms a dual natriuretic peptide system of the heart. BNP is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life .

HY-P3772

[Mpr7, DAla9] ANP (7-28), amide, rat	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
[Mpr7, DAla9] ANP (7-28), amide, rat is an atrial peptide .

HY-P3762

ANP (1-30), frog	Endothelin Receptor	Cardiovascular Disease Endocrinology
ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide derived from frog. ANP (1-30), frog has natriuretic, diuretic, and vasorelaxant effects.

HY-P10278

Anantin	Peptides	Endocrinology
Anantin binds competitively to the *receptor of atrial* natriuretic factor (ANF) from bovine adrenal cortex (K_d = 0.6 μM) and acts as natriuretic peptide receptor A** antagonist .

HY-P1556

Vasonatrin Peptide (VNP)	PKG	Cardiovascular Disease
Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .

HY-P10259

BNP(1-32), porcine pBNP-32	Natriuretic Peptide Receptor (NPR)	Neurological Disease
BNP(1-32), porcine (pBNP-32) is a cardiac hormone. BNP(1-32), porcine is an atrial natriuretic peptide, which exhibits natriuretic, diuretic and vasorelaxant effects. BNP(1-32), porcine affects passive avoidance learning in rats with dopaminergic, cholinergic, α-and β-adrenergic mediation .

HY-P3774

*[Tyr8]-Atrial* Natriuretic Peptide (5-27), rat**	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease Endocrinology
[Tyr8]-Atrial Natriuretic Peptide (5-27), rat is an atrial natriuretic peptide (ANP) analog that relaxes smooth muscle without affecting cGMP levels .

HY-P2281

Atrial natriuretic factor (1-28) (human, porcine) atrial natriuretic peptide (1-28)	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Atrial natriuretic factor (1-28) (human, porcine) exhibits blood pressure lowering activity by increasing sodium and urine excretion. Atrial natriuretic factor (1-28) (human, porcine) inhibits the release of pituitary adrenocorticotropic hormone (ACTH) and beta-endorphin through inhibition of pro-opiomelanocortin (POMC) expression. Atrial natriuretic factor (1-28) (human, porcine) increases cGMP levels in RMIC cells with an IC₅₀ of 1.2 nM .

HY-P10279

Anaritide Human atrial natriuretic factor (102–126)	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease Others
Anaritide is a synthetic form of atrial natriuretic peptide (ANP) composed of 25 amino acids. Anaritide increases glomerular filtration rate by dilating into and contracting out the bulbar arterioles. Anaritide can be used to study the effects on patients with acute tubular necrosis, particularly in improving dialysis free survival .

HY-P3767

Auriculin B ANP (126-150) (Rat); atrial natriuretic peptide(126-150)(rat)	Peptides	Cardiovascular Disease Metabolic Disease
Auriculin B (ANP (126-150) (Rat)) is a rat-derived atrial natriuretic peptide. Auriculin B has potent vasodilatory and diuretic properties .

HY-P1419A

AP 811 acetate	Endothelin Receptor	Cardiovascular Disease
AP 811 acetate is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K_i of 0.48 nM. AP 811 acetate displays >20000-fold selectivity for NPR3 over NPR1. AP 811 acetate abolishes ANP-induced pump stimulation .

HY-P10260

BNP(7-32), porcine pBNP-26	Biochemical Assay Reagents	Others
BNP (7-32), porcine (pBNP-26) is an atrial natriuretic peptide, which utilized in radioimmunoassay .

HY-P10248

Atriopeptin I (rat, mouse)	Androgen Receptor	Endocrinology
Atriopeptin I rat, mouse is an atrial natriuretic peptide, which stimulates the testosterone production with half-maximum stimulation of 38 nM .

HY-P3060

Atriopeptin II (rat, mouse)	Peptides	Cardiovascular Disease
Atriopeptin II rat, mouse is an atrial natriuretic peptide, which acts as diuretic and natriuretic agent, and a potent relaxant of vascular smooth muscle .

HY-P1980

A-71915 TFA	Apoptosis	Metabolic Disease
A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriuretic peptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells .

HY-P5978

Atriopeptin III (rat) ANP 127-150 (rat)	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Atriopeptin III (ANP 127-150) (rat), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent. Atriopeptin III (rat) improves renal functions and decreases blood pressure in a ureter-obstructed rat kidney model. Atriopeptin III (rat) can be used for research of chronic renal failure .

HY-P1556A

Vasonatrin Peptide (VNP) TFA	PKG	Metabolic Disease
Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .

HY-P11210

A68828	Biochemical Assay Reagents	Inflammation/Immunology
A68828 is an atrial natriuretic factor (ANF) analog. A68828 can improve renal function in an acute model of postischemic acute renal failure. A68828 can be studied in research on ischemic acute renal failure .

HY-P11367

Boc-Ala-Gly-Pro-Arg-AMC	Fluorescent Dye Ser/Thr Protease	Infection Metabolic Disease
Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113283

Homogentisic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin
Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as *Aβ_1-42, α-synuclein, SAA, Transthyretin (TTR), atrial* natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin** pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .

HY-A0154

Deslanoside Deacetyllanatoside C; Desacetyllanatoside C	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Cardiacglycosides Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Na+/K+ ATPase Drug Metabolite
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-Y0265

Isatin Indoline-2,3-dione	Cardiovascular Disease Alkaloids other families Neurological Disease Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification	Monoamine Oxidase Apoptosis
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-34350

2-(Aminomethyl)phenol 2-Hydroxybenzylamine; o-Hydroxybenzylamine; 2-HOBA	Cardiovascular Disease Monophenols Reseda odorata L. Oleaceae Classification of Application Fields Phenols Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species (ROS)
2-(Aminomethyl)phenol (2-Hydroxybenzylamine) is a selective dicarbonyl scavenger. 2-(Aminomethyl)phenol is an antioxidant and scavanger of free radicals and isolevuglandins (IsoLGs). 2-(Aminomethyl)phenol can prevent early recurrence of atrial fibrillation. 2-(Aminomethyl)phenol can reduce inflammation and plaque apoptotic cells and promote efferocytosis and features of stable plaques. 2-(Aminomethyl)phenol can reduce malondialdehyde (MDA)-LDL and MDA-HDL levels in Ldlr ^-/- mouse model. 2-(Aminomethyl)phenol can be studied in the research of inflammation and cardiovascular disease, such as atherosclerosis, early recurrence of atrial fibrillation (AF) and arrhythmias .

HY-136933

Gitoxin	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Na+/K+ ATPase
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure .

HY-N5016

Guvacoline hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Pyridine Alkaloids Plants Palmae Areca triandra Roxb. Disease Research Fields Source Classification	mAChR
Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors .

HY-101245

Pilsicainide hydrochloride SUN-1165; Pilzicainidehydrochloride	Pyrrolizidine Alkaloids Alkaloids	Sodium Channel
Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent .

HY-N3931

Gardneramine	Alkaloids Nepenthes mirabilis (Lour.) Druce Plants Nepenthaceae Source Classification	Others
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines .

HY-129665

GS-389 (±)-O,O-Dimethylcoclaurine	Alkaloids Cocculus laurifolius DC. Plants Isoquinoline Alkaloids Menispermaceae Source Classification	Endogenous Metabolite
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K ⁺ in rat aortic rings .

HY-N5170

Aselacin A	Natural Products Microorganisms Source Classification	Endothelin Receptor
Aselacin A targets endothelin-1 receptor (ET-1 receptor), inhibits the the binding of ET-1 to ETA receptor and ETB receptor. Aselacin A inhibits the ET-1 binding to bovine atrial membrane and porcine cerebral membrane with IC₅₀ of 22 μg/mL and 20 μg/mL. Aselacin A can be used for research of cardiovascular diseases .

HY-A0154R

Deslanoside (Standard) Deacetyllanatoside C (Standard); Desacetyllanatoside C (Standard)	Digitalis purpurea Linn. Structural Classification Cardiacglycosides Scrophulariaceae Plants Steroids Source Classification	Reference Standards Na+/K+ ATPase Drug Metabolite
Deslanoside (Standard) is the analytical standard of Deslanoside. This product is intended for research and analytical applications. Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-N0747R

Oxypeucedanin (Standard)	Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Reference Standards Potassium Channel Apoptosis PI3K NF-κB Akt p38 MAPK ERK COX NO Synthase JNK
Oxypeucedanin (Standard) is a furanocoumarin derivative found in Angelica dahurica. Oxypeucedanin (Standard) is an orally active PI3K/AKT/NF-κB, MAPK, and ROS inhibitor. Oxypeucedanin (Standard) induces cell cycle arrest and apoptosis. Oxypeucedanin (Standard) inhibits hKv1.5 channel currents (IC₅₀: 76 nM). Oxypeucedanin (Standard) exhibits anticancer, anti-inflammatory, antioxidant and antiarrhythmic activities .

HY-121239

Lemnalol	Structural Classification Natural Products Animals Source Classification	NF-κB
Lemnalol is a potent agent for neuropathic pain. Lemnalol possesses potent anti-inflammatory, analgesic and anti-tumor activities. Lemnalol has the capacity to attenuate hyperalgesia and allodynia by modulation of neuroinflammatory processes in neuropathy. Lemnalol modulates LPS-induced alterations of left atrial (LA) calcium homeostasis and blocks the NF-κB pathways, which may contribute to the attenuation of lipopolysaccharide (LPS)-induced arrhythmogenesis and neuropathic pain. Lemnalolis a ylangene-type sesquiterpenoid compound, isolated from Lemnalia cervicorni .

HY-Y0265R

Isatin (Standard) Indoline-2,3-dione (Standard)	Alkaloids Structural Classification other families Plants Indole Alkaloids Source Classification	Reference Standards Monoamine Oxidase Apoptosis
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

Species:	Human (2)
Tag:	His (1) Avi (1) Fc (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703923

	NPR1/NPRA Protein, Human (HEK293, Fc) atrial natriuretic peptide receptor 1; NPR1; NPRA; GC-A; ANPRA; NPR-A	Human	HEK293
	NPR1 Protein, a receptor for atrial natriuretic peptide NPPA/ANP and brain natriuretic peptide NPPB/BNP, initiates signaling cascades with guanylate cyclase activity upon ligand binding. Essential vasoactive hormones, these peptides regulate cardiovascular homeostasis. NPR1 significantly contributes to vascular tone and fluid balance regulation in the cardiovascular system through its role as a receptor for these natriuretic peptides. NPR1/NPRA Protein, Human (HEK293, Fc) is the recombinant human-derived NPR1 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P704143

	NPR1/NPRA Protein, Human (Biotinylated, HEK293, His, Avi) atrial natriuretic peptide receptor 1; NPR1; NPRA; GC-A; ANPRA; NPR-A	Human	HEK293
	NPR1 Protein, a receptor for atrial natriuretic peptide NPPA/ANP and brain natriuretic peptide NPPB/BNP, initiates signaling cascades with guanylate cyclase activity upon ligand binding. Essential vasoactive hormones, these peptides regulate cardiovascular homeostasis. NPR1 significantly contributes to vascular tone and fluid balance regulation in the cardiovascular system through its role as a receptor for these natriuretic peptides. NPR1/NPRA Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived NPR1/NPRA protein, expressed by HEK293, with C-His and C-Avi labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0432AS4

Propafenone-(phenyl-d5) hydrochloride
Propafenone-(phenyl-dd₅) (hydrochloride) is the deuterium labeled Propafenone hydrochloride[1]. Propafenone hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[2].

HY-10274S

Dabigatran etexilate-d13
Dabigatran etexilate-d₁₃ is the deuterium labeled Dabigatran etexilate. Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran. Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation .

HY-A0016S

Dronedarone-d6 hydrochloride

Dronedarone-d₆ (hydrochloride) is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4 .

HY-B0432AS2

Propafenone-d5 hydrochloride
Propafenone-d₅ (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79) hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].

HY-A0016S3

Dronedarone-d6

Dronedarone-d₆ (SR 33589-d₆) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4 .

HY-B0432AS3

Propafenone-d5 hydrochloride(Ethyl)
Propafenone-d₅ Ethyl (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79）hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias .

HY-W705434

Dabigatran etexilate-d11
Dabigatran etexilate-d₁₁ (BIBR 1048-d₁₁) is the deuterium labeled Dabigatran etexilate (HY-10274). Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation .

HY-B0588AS

Brinzolamide-d5 hydrochloride

Brinzolamide-d₅ (hydrochloride) is the deuterium labeled Brinzolamide hydrochloride . Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research .

HY-17494S1

Timolol-d9 maleate

Timolol-d₉ (maleate) is deuterium labeled Timolol. Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .

HY-18600AS

Azimilide-d8 dihydrochloride

Azimilide-d₈ (NE-10064-d₈) dihydrochloride is the deuterium labeled Azimilide dihydrochloride (HY-18600A). Azimilide dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of I_Ks (IC₅₀ = 2.6 μM (2mM [K⁺]ₑ)) and I_Kr (IC₅₀ = 1 μM (4 mM [K⁺])). Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC₅₀s of 1.4 μM and 5.2 μM respectively. Azimilide dihydrochloride also inhibits L-type calcium current (I_Ca) (IC₅₀ = 17.8 μM) and sodium current (I_Na) (IC₅₀ = 19 μM). Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation .

Host:	Rabbit (2)
Reactivity:	Human (2) mouse (1) rat (1)
Application:	WB FC ICC/IF (1) IP (1) WB (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2) Biotin (1)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810474

	NPR3 Antibody (YA9772) NPR3, Natriuretic Peptide Receptor 3, C5orf23, GUCY2B, ANPRC, NPRC, Natriuretic Peptide Receptor C/Guanylate Cyclase C (Atrionatriuretic Peptide Receptor C), atrial Natriuretic Peptide Clearance Receptor, atrial Natriuretic Peptide Receptor Type C, atrial Natriuretic Peptide Receptor 3, Atrionatriuretic Peptide Receptor C, Guanylate Cyclase C, FLJ14054, ANPR-C, ANP-C, NPR-C, Chromosome 5 Open Reading Frame 23, Natriuretic Peptide Receptor C, BOMOS	WB FC ICC/IF	Human, mouse, rat
	NPR3 Antibody (YA9772) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to NPR3.

HY-P81636

	Natriuretic Peptides A Antibody (YA1381) ANF antibody; ANF_HUMAN antibody; ANP antibody; ATFB6 antibody; atrial natriuretic factor antibody; atrial natriuretic peptide antibody; Atriopeptin antibody; Cardiodilatin antibody; Cardiodilatin related peptide antibody; Cardiodilatin-related peptide antibody; Cardionatrin antibody; CDD ANF antibody; CDD antibody; CDD-ANF antibody; CDP antibody; Natriuretic peptide A antibody; Natriuretic peptide precursor A antibody; NPPA antibody; PND antibody; Prepronatriodilatin antibody	WB, IP	Human
	Natriuretic Peptides A Antibody (YA1381) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Natriuretic Peptides A.