197431-02-0
Chemical Structure
Debutyldronedarone hydrochloride
Synonym(s): SR35021 hydrochloride
- CAS No.: 197431-02-0
- Formula:C27H37ClN2O5S
- Molecular Weight:537.11
IUPAC Name: N-(2-butyl-3-(4-(3-(butylamino)propoxy)benzoyl)benzofuran-5-yl)methanesulfonamide hydrochloride
InChIKey: ZDXBTJLIQYUYSZ-UHFFFAOYSA-N
SMILES: O=C(C1=C(CCCC)OC2=C1C=C(NS(=O)(C)=O)C=C2)C3=CC=C(C=C3)OCCCNCCCC.Cl
Biological Activity: Debutyldronedarone hydrochloride (SR35021 hydrochloride) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone hydrochloride inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone hydrochloride reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone hydrochloride can be used in studies related to ventricular fibrillation and atrial fibrillation[1][2].
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Debutyldronedarone hydrochloride | 98.32% | Debutyldronedarone hydrochloride (SR35021 hydrochloride) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone hydrochloride inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone hydrochloride reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone hydrochloride can be used in studies related to ventricular fibrillation and atrial fibrillation. | ||||||||||||||||||||
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Debutyldronedarone hydrochloride (Standard) | ≥98% | Debutyldronedarone hydrochloride (Standard) (SR35021 hydrochloride (Standard)) is the analytical standard of Debutyldronedarone (hydrochloride) (HY-12753A). This product is intended for research and analytical applications. Debutyldronedarone hydrochloride (SR35021 hydrochloride) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone hydrochloride inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone hydrochloride reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone hydrochloride can be used in studies related to ventricular fibrillation and atrial fibrillation. | ||||||||||||||||||||
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Debutyldronedarone-d7 hydrochloride | Debutyldronedarone-d7 hydrochloride (SR35021-d7 hydrochloride) is the deuterated-labeled Debutyldronedarone (hydrochloride) (HY-12753A). Debutyldronedarone hydrochloride (SR35021 hydrochloride) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone hydrochloride inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone hydrochloride reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone hydrochloride can be used in studies related to ventricular fibrillation and atrial fibrillation. | |||||||||||||||||||||
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- [1]. Therapeutic Goods Administration. Australian Public Assessment Report for Dronedarone Hydrochloride, submission PM-2008-3045-3, Australian Government Department of Health and Ageing, 2008.
- [2]. Van Beeren HC, et al. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology. 2003 Feb;144(2):552-8. [Content Brief]
