1. DPO-1

DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype Kv1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia.

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DPO-1 Chemical Structure

DPO-1 Chemical Structure

CAS No. : 43077-30-1

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 138 In-stock
Solution
10 mM * 1 mL in DMSO USD 138 In-stock
Solid
5 mg USD 125 In-stock
10 mg USD 200 In-stock
25 mg USD 440 In-stock
50 mg USD 750 In-stock
100 mg USD 1200 In-stock
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Description

DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype Kv1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia[1][2].

Molecular Weight

340.44

Formula

C22H29OP

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC([C@H]1[C@@H](P(C2=CC=CC=C2)(C3=CC=CC=C3)=O)C[C@H](C)CC1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (29.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9374 mL 14.6869 mL 29.3738 mL
5 mM 0.5875 mL 2.9374 mL 5.8748 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9374 mL 14.6869 mL 29.3738 mL 73.4344 mL
5 mM 0.5875 mL 2.9374 mL 5.8748 mL 14.6869 mL
10 mM 0.2937 mL 1.4687 mL 2.9374 mL 7.3434 mL
15 mM 0.1958 mL 0.9791 mL 1.9583 mL 4.8956 mL
20 mM 0.1469 mL 0.7343 mL 1.4687 mL 3.6717 mL
25 mM 0.1175 mL 0.5875 mL 1.1750 mL 2.9374 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DPO-1
Cat. No.:
HY-100712
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