Cat. No.: HY-100712

DPO-1

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

DPO-1 is a potent Kv1.5 and Kv1.3 (EC₅₀ = 3.1 μM) channels inhibitor with potential immunomodulatory and anti-inflammatory effects. DPO-1 reduces Kv1.3 current density, blunts Ca²⁺ influx in Ca²⁺-depleted Jurkat cells, and inhibits IL-2 secretion in activated Jurkat cells. DPO-1 inhibits Uric acid sodium (HY-B2130A) (MSU)-induced NLRP3 inflammasome activation by blocking Kv1.5-mediated K⁺ efflux. DPO-1 can be used for the study of immunologic disorders and atrial fibrillation.

For research use only. We do not sell to patients.

Purity: 98.39%
CAS No.: 43077-30-1
Formula: C₂₂H₂₉OP
Molecular Weight:340.44

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

DPO-1 Chemical Structure

CAS No.: 43077-30-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Calcium Channel Isoforms :

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	30 nM Compound: 1, DPO-1	Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay	[PMID: 20304642]

In Vitro

DPO-1 (1-10 μM) inhibits outward K⁺ currents in mesenteric artery VSMCs from wild-type (Kcna5^+/+) mice, with a more potent inhibitory effect than in VSMCs from Kcna5^-/- mice^[1].
DPO-1 (10 μM, 30 min) induces stable vasocontraction in mesenteric artery rings without PVAT in Kcna5^+/+ and Kcna5^-/- mice^[1].
DPO-1 (0.3-30 μM) blocks Kv1.3 current in a voltage-dependent and concentration-dependent manner in Jurkat cells and human peripheral blood T cells, with IC₅₀ values of 2.58 μM (Jurkat cells) and 3.11 μM (human peripheral blood T cells)^[2].
DPO-1 (1-10 μM, 24 h) decreases Kv1.3 current density at +40 mV in Jurkat cells and reduces Kv1.3 protein expression^[2].
DPO-1 (0.1-3 μM, 24 h) blunts Ca²⁺ influx in Ca²⁺-depleted Jurkat cells induced by Thapsigargin (TG) (HY-13433)^[2].
DPO-1 (3-10 μM, 24 h) inhibits IL-2 secretion in activated Jurkat cells^[2].
DPO-1 (0-100 μM, 6 h) concentration-dependently reduces caspase-1 (p20) and IL-1β (p17) protein levels, prevents intracellular K⁺ concentration decrease, suppresses ASC oligomerization and speck formation in LPS (HY-D1056)-primed J774.1 mouse macrophages^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 43077-30-1
Appearance Solid
Molecular Weight 340.44
Formula C₂₂H₂₉OP
Color White to off-white
SMILES

CC([C@H]1[C@@H](P(C2=CC=CC=C2)(C3=CC=CC=C3)=O)C[C@H](C)CC1)C
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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2025 Nov 12.

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (29.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9374 mL

14.6869 mL

29.3738 mL

5 mM

0.5875 mL

2.9374 mL

5.8748 mL

10 mM

0.2937 mL

1.4687 mL

2.9374 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tsvetkov D, et al. The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of Vascular Tone. Front Physiol. 2016 Aug 4;7:335. [Content Brief]

[2]. Zhao N, et al. Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. PLoS One. 2013 May 22;8(5):e64629. [Content Brief]

[3]. Li P, et al. Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. Mol Biol Rep. 2022 Jul;49(7):5939-5952. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9374 mL	14.6869 mL	29.3738 mL	73.4344 mL
	5 mM	0.5875 mL	2.9374 mL	5.8748 mL	14.6869 mL
	10 mM	0.2937 mL	1.4687 mL	2.9374 mL	7.3434 mL
	15 mM	0.1958 mL	0.9791 mL	1.9583 mL	4.8956 mL
	20 mM	0.1469 mL	0.7343 mL	1.4687 mL	3.6717 mL
	25 mM	0.1175 mL	0.5875 mL	1.1750 mL	2.9374 mL

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DPO-1

Immunology/Inflammation Compound Library

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

NF-κB Signaling Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Pyroptosis Compound Library

Anti-Alzheimer's Disease Compound Library

Neuroprotective Compound Library

Neurodegenerative Disease-related Compound Library

Angiogenesis-Related Compound Library

Antidepressant Compound Library

Calcium Channel Blocker Library

Potassium Channel Compound Library

Antihypertensive Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Cytokine Inhibitors Library

Ion Channel Compound Library

Inflammasomes related Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Pattern Recognition Receptors Library

Publications Citing Use of MedChemExpress (MCE) DPO-1

All Calcium Channel Isoforms

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

DPO-1 Related Classifications

HY-100712 Related Classifications