27 Results for "

cd40-ligand

" in MedChemExpress (MCE) Product Catalog:
Products (27)

27 Results for "cd40-ligand" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P72907
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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2
2 Cited Publications
Cat. No.: HY-P72908
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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Cat. No.: HY-P990083
CAS No.: 2628092-47-5
Synonyms: AT-1501

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Tegoprubart (AT-1501) is a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. Tegoprubart suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart is applicable to research related to kidney transplantation and kidney transplant rejection .
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Cat. No.: HY-P99625
CAS No.: 2515463-86-0
Synonyms: SAR441344; INX-021

Target:  

TNF Receptor

Frexalimab (SAR441344) is a second-generation monoclonal antibody targeting the CD40 ligand (CD40L) with a good safety profile. Frexalimab inhibits the binding between CD40 and CD40L to modulate immune response. Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sj gren’s syndrome and type I diabetes research .
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Cat. No.: HY-P99325
CAS No.: 252662-47-8
Synonyms: IDEC-131; Anti-Human cd40 ligand Recombinant Antibody

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab is an immunosuppressive agent. Toralizumab can lead to increased thrombosis. Toralizumab can be studied in research for diseases such as multiple sclerosis, systemic lupus erythematosus (SLE), and Crohn’s disease .
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Cat. No.: HY-P991557

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

ABI793 is a human IgG1 anti-human CD154 (CD40 ligand) monoclonal antibody. ABI793 inhibits immune response by blocking the CD154-CD40 (IC50 = 75 nM) signaling pathway. ABI793 effectively prevents kidney transplant rejection. ABI793 can be used for research on immunological rejection .
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Cat. No.: HY-P705466
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; TRAP; Tumor necrosis factor ligand superfa; cd40 ligand; cd154; cd40lg; cd40l; Tnfsf5
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Cat. No.: HY-P990083A
CAS No.: 2628092-47-5
Synonyms: AT-1501 (powder)

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Tegoprubart (powder) (AT-1501 (powder)) is a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. Tegoprubart (powder) suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart (powder) preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart (powder) is applicable to research related to kidney transplantation and kidney transplant rejection .
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Cat. No.: HY-174737
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CD40LG mRNA encodes the human CD40 ligand (CD40LG) protein, a protein that is expressed on the surface of T cells. CD40LG regulates B cell function by engaging CD40 on the B cell surface.
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Cat. No.: HY-P72121
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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Cat. No.: HY-P72122
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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Cat. No.: HY-D1236
CAS No.: 16090-02-1
Fluorescent brightener 71 (FB71) is an inhibitor targeting deubiquitinases UCHL5 and USP14, as well as a CD40 ligand. Fluorescent brightener 71 blocks enzymatic activity, induces apoptosis, inhibits cell growth and triggers reactive oxygen species production. Meanwhile, Fluorescent brightener 71 upregulates the expression of oxidative stress-related genes gpx-4 and sod-4, and reversibly increases the protein levels of UCHL5 and USP14 through a feedback response. Fluorescent brightener 71 inhibits the growth, movement and reproductive capacity of Caenorhabditis elegans, and also exhibits concentration-dependent toxic effects. Fluorescent brightener 71 can be applied to scientific research in related fields such as breast cancer .
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Cat. No.: HY-P72907AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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Cat. No.: HY-P810855
Synonyms: cd154, cd40L, TNFSF5, TRAP, cd40LG, cd40 ligand, cd40-L, T-cell antigen Gp39, TNF-related activation protein, Tumor necrosis factor ligand superfamily member 5

Host:  

Rabbit

Application:  

WB, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P78934
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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Cat. No.: HY-P71910
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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Cat. No.: HY-P70609
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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Cat. No.: HY-P70808
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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Cat. No.: HY-P72358
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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Cat. No.: HY-P75407
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: cd40LG; T-BAM; Prev. TNFSF5; Tumor Necrosis Factor (ligand) Superfamily Member 5; Prev. HIGM1; Tumor Necrosis Factor ligand Superfamily Member 5; Prev. IMD3; T-B Cell-Activating Molecule; cd40-L; cd40 Antigen ligand; cd40L; T-Cell Antigen Gp39; TRAP; Tumo
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