Copy Link Print Information

Tegoprubart

(Synonyms: AT-1501)
Customer Review

Based on 1 Customer Validation

Tegoprubart (AT-1501) is a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. Tegoprubart suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart is applicable to research related to kidney transplantation and kidney transplant rejection.

For research use only. We do not sell to patients.

  • Purity: 99.86%
  • CAS No.: 2628092-47-5
  • Molecular Weight:145.56 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tegoprubart
  • Experimental Validation Results for Tegoprubart
  • Experimental Validation Results for Tegoprubart
  • Experimental Validation Results for Tegoprubart
  • Tegoprubart Chemical Structure
    Tegoprubart Chemical Structure
CAS No.: 2628092-47-5
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Tegoprubart:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

All TNF Receptor Isoforms

More
Keywords
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized CD40L/CD154/TRAP Protein, Human (His, HY-P72907) can bind Tegoprubart. The EC50 for this effect is 4.211 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 500 ng/mL anti-CD3 stimulated Jurkat cells(24h) with Tegoprubart (HY-P990083, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Loaded Tegoprubart on ProA biosensor, can bind CD40L/CD154/TRAP Protein, Human (HY-P7144) with an affinity constant of 4.923E-10 M as determined in BLI assay.

  • Tegoprubart Chemical Structure
    1/16
  • Tegoprubart
  • Immobilized CD40L/CD154/TRAP Protein, Human (His, HY-P72907) can bind Tegoprubart. The EC50 for this effect is 4.211 ng/mL.
  • Flow cytometric analysis of 1X106 500 ng/mL anti-CD3 stimulated Jurkat cells(24h) with Tegoprubart (HY-P990083, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Loaded Tegoprubart on ProA biosensor, can bind CD40L/CD154/TRAP Protein, Human (HY-P7144) with an affinity constant of 4.923E-10 M as determined in BLI assay.