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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
chymase
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "chymase" in MCE Product Catalog:
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Fulacimstat is an orally available chymase inhibitor, with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively.
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1 Cited Publications
Cat. No.: HY-P4159
CAS No.: 133972-52-8
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1 Cited Publications
Cat. No.: HY-P4159A
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1 Cited Publications
Cat. No.: HY-P4476
CAS No.: 72682-69-0
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1 Cited Publications
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TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
Cathepsin C is a lysosomal cysteine protease essential for catalytic activation of many serine proteases, including proteinase 3 (PR3), neutrophil elastase (NE), cathepsin G (CTSG), granzyme A/B/C, and mast cell chymase .
Cat. No.: HY-122161
CAS No.: 518062-14-1
Synonyms: RWJ-355871
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JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity .
Cat. No.: HY-100269
CAS No.: 862090-74-2
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Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
Cat. No.: HY-131162
CAS No.: 97501-92-3
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Chymase is a protein-digester enzyme found primarily in mast cells (MC), fibroblasts, and vascular endothelial cells. Chymase is released into the extracellular stroma in the context of inflammatory signals, tissue injury and cellular stress. Chymase is also involved in angiotensin II (Ang II) production, which is used in cardiovascular disease studies .
Cat. No.: HY-P4159B
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Cat. No.: HY-U00282
CAS No.: 936366-22-2
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Chymase-IN-2 is a chymase modulator which is useful in the treatment of inflammatory and serine protease mediated disorders.
Cat. No.: HY-16707
CAS No.: 252557-97-4
Synonyms: Z-Ile-Glu-Pro-Phe-Ome
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Cat. No.: HY-P1347
CAS No.: 1160928-63-1
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Cat. No.: HY-P1347A
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Cat. No.: HY-168904
CAS No.: 1236524-95-0
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BI-1942, a chemical probe, is a chymase inhibitor and has an IC50 of 0.4 nM for human chymase. BI-1942 can be used in the research of ophthalmic diseases .
Cat. No.: HY-RS02853
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CMA1 Human Pre-designed siRNA Set A contains three designed siRNAs for CMA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-12514
CAS No.: 204460-24-2
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NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein .
Cat. No.: HY-126988
CAS No.: 70857-49-7
Synonyms: α-MAPI
SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase .
Cat. No.: HY-Y0370
CAS No.: 56341-37-8
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6-Chlorooxindole (compound 2) is a selective chymase inhibitor with an IC50 of 470 μM. 6-Chlorooxindole shows >100-fold selectivity for chymase over cathepsin G. 6-Chlorooxindole can be used for the study of cardiovascular disease .
Cat. No.: HY-P74252
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Alpha-chymase; Mast cell chymase 1; Mast cell protease 5; mMCP-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
