1160928-63-1
1160928-63-1
Chemical Structure
RETF-4NA
- CAS No.: 1160928-63-1
- Formula:C32H43N9O10
- Molecular Weight:713.74
IUPAC Name: (S)-4-((S)-2-acetamido-5-guanidinopentanamido)-5-(((2S,3R)-3-hydroxy-1-(((S)-1-((4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxobutan-2-yl)amino)-5-oxopentanoic acid
InChIKey: MGCWUIJMQAZRNY-SJYYQWPBSA-N
SMILES: O=C(NC1=CC=C(C=C1)[N+]([O-])=O)[C@@H](NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)=O)CC2=CC=CC=C2
Biological Activity: RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α2M[1][2].
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RETF-4NA | RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α2M. | |||||||||||||||||||||
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References
- [1]. Wilfred W Raymond, et al. Alpha 2-macroglobulin Capture Allows Detection of Mast Cell Chymase in Serum and Creates a Reservoir of Angiotensin II-generating Activity. J Immunol. 2009 May 1;182(9):5770-7. [Content Brief]
- [2]. Katariina Maaninka, et al. Human Mast Cells Arise From a Common Circulating Progenitor. J Allergy Clin Immunol. 2013 Aug;132(2):463-9.e3. [Content Brief]
Keywords
