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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
cigarette smoke
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "cigarette smoke" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W015635
CAS No.: 2179-57-9
1
1 Cited Publications
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PHA-408 is a highly selective, orally active and ATP-competitive IKK-2 inhibitor with an IC50 of 40 nM. PHA-408 blocks NF-κB signaling by suppressing IκBα phosphorylation and degradation, p65 phosphorylation, and pro-inflammatory cytokine production, and prevents TNF-α-induced premature senescence in HUVECs. PHA-408 alleviates LPS-and cigarette smoke-triggered pulmonary inflammation, reduces LPS-stimulated serum TNF-α release, and ameliorates joint damage in SCW-induced arthritis in rats. PHA-408 is applicable for the research of rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and Duchenne muscular dystrophy .
Cat. No.: HY-W089538
CAS No.: 1687-64-5
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β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .
Cat. No.: HY-W008030
CAS No.: 2243-47-2
3-Aminobiphenyl is a chemical isomer of 4-ABP. 3-Aminobiphenyl can inhibit the growth of human intestinal bacteria Bifidobacterium infantis ATCC 15697, B. bifidium ATCC 11863, Clostridium perfringens ATCC 13124, Escherichia coli ATCC 25922, E. coli ATCC 35218, Enterobacter cloacae ATCC 13047 and Salmonella typhimurium TA98, TA100, YG1041. 3-Aminobiphenyl can be used as a biomarker of exposure to aromatic amines from cigarette smoke .
Synonyms: 2-Amino-α-carboline; AαC
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AalphaC (AαC) is a potential carcinogen with carcinogenic activity. AalphaC is an important biomarker in tobacco smoke and is associated with tobacco smoke exposure. Urinary concentrations of AalphaC are significantly higher in dedicated smokers than in non-smokers, indicating its importance in monitoring tobacco exposure. AalphaC levels increase significantly with increasing serum nicotine levels, indicating its close relationship with tobacco use. In addition, consuming high-temperature cooked beef significantly increases the amount of AalphaC in urine, while consuming vegetables is associated with a decrease in AalphaC concentrations. Smoking half a pack of cigarettes is associated with a significant increase in the amount of AalphaC, which further confirms the biological activity of AalphaC and its association with dietary habits .
Cat. No.: HY-W587741
CAS No.: 144889-50-9
Synonyms: Dihydroxybutyl mercapturic acid; DHBMA
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N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (Dihydroxybutyl mercapturic acid) is a biomarkersof 1,3-butadiene exposure. 1,3-Butadiene is a known human carcinogen present in cigarette smoke and in automobile exhaust.
Cat. No.: HY-113086
CAS No.: 16711-66-3
Synonyms: 16:1(9Z) CE; 16:1(9Z) Cholesterol ester; Cholesterol Palmitoleate
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CE(16:1(9Z)) (16:1(9Z) CE) is a cholesterol ester. Plasma levels of cholesteryl palmitoleate are increased in ApoE -/- mice exposed to cigarette smoke and in pediatric patients with biliary atresia. Cholesteryl palmitoleate has been used as a standard for the identification of cholesterol esters in human meibomian gland secretions.
Cat. No.: HY-W004681
CAS No.: 1121-78-4
Synonyms: 6-Methyl-3-pyridinol
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6-Methyl-3-pyridinol (5-hydroxy-2-methylpyridine) is a starting compound for the synthesis of L-azatyrosine (HY-W048303). 6-Methyl-3-pyridinol can be isolated from cigarette smoke condensate. 6-Methyl-3-pyridinol aggravates Collagen-induced arthritis in mice .
Cat. No.: HY-W089538R
CAS No.: 1687-64-5
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Cat. No.: HY-100702
CAS No.: 701976-54-7
SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke .
Cat. No.: HY-W700491
CAS No.: 1189920-50-0
Synonyms: 2-Amino-α-carboline-15N3; AαC-15N3
Cat. No.: HY-W015635R
CAS No.: 2179-57-9
Cat. No.: HY-122010
CAS No.: 300842-59-5
NVP-AAD777 is a specific inhibitor of VEGFR-2, demonstrated in vivo by its effective suppression of phospho-VEGFR-2 (Tyr1175) signaling in rat lung tissues. Unlike the nonspecific VEGFR inhibitor SUG-5416, NVP-AAD777 did not induce emphysematous changes in the lungs after three weeks of treatment, even when combined with exposure to cigarette smoke. Additionally, there were no alterations observed in vascular density compared to control animals. This indicates NVP-AAD777's targeted action in inhibiting VEGFR-2 without adverse pulmonary effects, highlighting its potential therapeutic utility in managing conditions associated with aberrant VEGFR-2 signaling .
Cat. No.: HY-160844
CAS No.: 2417155-47-4
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CT-133 is a selective and potent CRTH2 Receptor antagonist, with a Ki value of 2.2 nM. The Ki value for the DP1 receptor is greater than 3800 nM. CT-133 inhibits neutrophil migration induced by PGD2 (HY-101988). CT-133 significantly alleviates lung inflammation and improves lung function impairment in a mouse model of acute lung injury (ALI) induced by cigarette smoke. CT-133 effectively inhibits the excessive expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokines (KC), and reverses the inhibition of the anti-inflammatory factor IL-10. CT-133 can be used for the study of ALI .
Cat. No.: HY-W697750
CAS No.: 497-03-0
Synonyms: Tiglaldehyde
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Cat. No.: HY-W653722
CAS No.: 71267-22-6
Synonyms: (S)-N-NAT; (S)-N'-Nitrosoanatabine
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(S) -N-Nitrosoanatabine ( (S) -N-NAT) is a potent carcinogen and biomarker of exposure to cigarette smoke. It′s found in a variety of tobacco products and oral snuff.
Cat. No.: HY-118614R
CAS No.: 487-19-4
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β-Nicotyrine (Standard) is the analytical standard of β-Nicotyrine. This product is intended for research and analytical applications. β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .
Cat. No.: HY-121621
CAS No.: 1123155-95-2
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RO5101576 is a potent LTB4 receptor antagonist with activity to inhibit LTB4-induced calcium mobilization and chemotaxis of human neutrophils. RO5101576 significantly attenuated LTB4-induced pulmonary eosinophilia in guinea pigs. RO5101576 inhibited allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy comparable to that of budesonide. RO5101576 had no effect on LPS-induced neutrophilia in guinea pigs and cigarette smoke-induced neutrophilia in mice and rats. RO5101576 performed well in toxicology studies and was well tolerated .
Cat. No.: HY-135446
CAS No.: 141595-53-1
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BQ-610 is a selective antagonist of the endothelin A receptor (ETA receptor). BQ-610 specifically blocks the ETA receptor, competitively inhibiting the binding of endothelin-1 (ET-1) (a vasoconstrictive peptide) to the receptor, thereby blocking the effects of ET-1 such as vascular smooth muscle contraction, cell mitosis, and inhibition of hormone secretion. BQ-610 significantly alleviates cerebral vasospasm in rabbits. BQ-610 blocks the bronchial epithelial and pulmonary vascular cell proliferation caused by cigarette smoke in rat models. BQ-610 can delay the natural luteal regression in the cow's uterus. BQ-610 can be used for research on vasospasm, abnormal cell proliferation, and reproductive endocrine disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
