2179-57-9
Chemical Structure
Diallyl disulfide
- CAS No.: 2179-57-9
- Formula:C6H10S2
- Molecular Weight:146.27
IUPAC Name: 1,2-diallyldisulfane
InChIKey: PFRGXCVKLLPLIP-UHFFFAOYSA-N
SMILES: C=CCSSCC=C
Biological Activity: Diallyl disulfide is an orally active decomposition product of allicin and has a pungent odor. Diallyl disulfide can act as a hydrogen sulfide donor. Diallyl disulfide has inhibitory activity against squalene monooxygenase with an IC50 of 400 μM. Diallyl disulfide can alleviate the cytotoxicity and apoptosis of intestinal and liver cells induced by Ethyl Carbamate (HY-B1207). Diallyl disulfide can prevent emphysema induced by cigarette smoke. Diallyl disulfide also has anti-colon cancer and anti-inflammatory neurogenic activities, and can reverse the depressive-like behavior of mice[1][2][3][4][5].
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Diallyl disulfide | 99.8% | Diallyl disulfide is an orally active decomposition product of allicin and has a pungent odor. Diallyl disulfide can act as a hydrogen sulfide donor. Diallyl disulfide has inhibitory activity against squalene monooxygenase with an IC50 of 400 μM. Diallyl disulfide can alleviate the cytotoxicity and apoptosis of intestinal and liver cells induced by Ethyl Carbamate (HY-B1207). Diallyl disulfide can prevent emphysema induced by cigarette smoke. Diallyl disulfide also has anti-colon cancer and anti-inflammatory neurogenic activities, and can reverse the depressive-like behavior of mice. | ||||||||||||||||||||
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Diallyl disulfide (Standard) | ≥98% | Diallyl disulfide (Standard) is the analytical standard of Diallyl disulfide. This product is intended for research and analytical applications. Diallyl disulfide is an orally active decomposition product of allicin and has a pungent odor. Diallyl disulfide can act as a hydrogen sulfide donor. Diallyl disulfide has inhibitory activity against squalene monooxygenase with an IC50 of 400 μM. Diallyl disulfide can alleviate the cytotoxicity and apoptosis of intestinal and liver cells induced by Ethyl Carbamate (HY-B1207). Diallyl disulfide can prevent emphysema induced by cigarette smoke. Diallyl disulfide also has anti-colon cancer and anti-inflammatory neurogenic activities, and can reverse the depressive-like behavior of mice. | ||||||||||||||||||||
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Similarity Score 0.93
HY-117235RDiallyl Trisulfide (Standard) -
Similarity Score 0.88
HY-N9515Diallyl tetrasulfide -
Similarity Score 0.73
HY-106784Ajoene -
Similarity Score 0.73
HY-106784A(E)-Ajoene -
Similarity Score 0.73
HY-134900Allyl methyl trisulfide -
Similarity Score 0.71
HY-W106486Diallyldimethylammonium chloride (60% in water) -
Similarity Score 0.70
HY-W142921SAllyl methyl disulfide-d3 -
Similarity Score 0.68
HY-128447Allyl methyl sulfide -
Similarity Score 0.67
HY-W157144Diethyl disulfide -
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References
- [1]. Gupta N, et al. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. J Nutr. 2001;131(6):1662-1667. [Content Brief]
- [2]. You-Sheng Huang, et al. Diallyl disulfide inhibits the proliferation of HT-29 human colon cancer cells by inducing differentially expressed genes. Mol Med Rep. 2011 May-Jun;4(3):553-9. [Content Brief]
- [3]. Xiaoyou Wei, et al. Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress. Inflammation. 2021 Aug;44(4):1381-1395. [Content Brief]
- [4]. Aline de Oliveira Pontes Cardoso, et al. Diallyl disulfide prevents cigarette smoke-induced emphysema in mice. Pulm Pharmacol Ther. 2021 Aug:69:102053. [Content Brief]
- [5]. Sanchez CA, et al. Diallyl Disulfide Reduces Ethyl Carbamate-Induced Cytotoxicity and Apoptosis in Intestinal and Hepatic Cells. Chem Res Toxicol. 2025 Apr 21;38(4):623-634. [Content Brief]
