Cat. No.: HY-134900

Allyl methyl trisulfide

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Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities.

For research use only. We do not sell to patients.

Purity: 40.00%
CAS No.: 34135-85-8
Formula: C₄H₈S₃
Molecular Weight:152.30

Storage:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Allyl methyl trisulfide Chemical Structure

CAS No.: 34135-85-8

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Biological Activity
- Description
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities^[1].

In Vivo

Allyl methyl trisulfide (AMS) (50-200 mg/kg, orally, daily, 30 days) has protective effect in STZ-induced hyperglycemia rats. It can lead to a significant decrease in the expression of blood glucose and pro-inflammatory markers TNF-α, IL-6, and NF-κB p65, while increasing plasma insulin levels, and has some antioxidant activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats (170-190 g)^[1]
Dosage:

50, 100 and 200 mg/kg
Administration:

orally in the daily morning for 30 days
Result:

Enhanced body, organ weight and reduced food, water intake.
Dose-dependently decreased plasma glucose and enhanced insulin.
Attenuated the oxidative stress stimulated by STZ in hepatocytes.
Increased activity of hepatotoxicity markers AST, ALT and ALP.
Significantly downregulated the expression of pro-inflammatory proteins, cytokines (TNF-α and IL-6) and transcription factors (NF-κB p65).

Chemical Information

CAS No. 34135-85-8
Appearance Liquid
Molecular Weight 152.30
Formula C₄H₈S₃
Color Colorless to light yellow
SMILES

CSSSCC=C
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 200 mg/mL (1313.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.5660 mL

32.8299 mL

65.6599 mL

5 mM

1.3132 mL

6.5660 mL

13.1320 mL

10 mM

0.6566 mL

3.2830 mL

6.5660 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (32.83 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kathiroli Sujithra, et al. Allyl methyl sulfide, an organosulfur compound alleviates hyperglycemia mediated hepatic oxidative stress and inflammation in streptozotocin - induced experimental rats. Biomed Pharmacother. 2018 Nov;107:292-302. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.5660 mL	32.8299 mL	65.6599 mL	164.1497 mL
	5 mM	1.3132 mL	6.5660 mL	13.1320 mL	32.8299 mL
	10 mM	0.6566 mL	3.2830 mL	6.5660 mL	16.4150 mL
	15 mM	0.4377 mL	2.1887 mL	4.3773 mL	10.9433 mL
	20 mM	0.3283 mL	1.6415 mL	3.2830 mL	8.2075 mL
	25 mM	0.2626 mL	1.3132 mL	2.6264 mL	6.5660 mL
	30 mM	0.2189 mL	1.0943 mL	2.1887 mL	5.4717 mL
	40 mM	0.1641 mL	0.8207 mL	1.6415 mL	4.1037 mL
	50 mM	0.1313 mL	0.6566 mL	1.3132 mL	3.2830 mL
	60 mM	0.1094 mL	0.5472 mL	1.0943 mL	2.7358 mL
	80 mM	0.0821 mL	0.4104 mL	0.8207 mL	2.0519 mL
	100 mM	0.0657 mL	0.3283 mL	0.6566 mL	1.6415 mL

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Allyl methyl trisulfide

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Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Allyl methyl trisulfide Related Classifications

HY-134900 Related Classifications