Allyl methyl trisulfide
Based on 1 Customer Validation
Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities.
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- Pureza : 40.00%
- No. CAS: 34135-85-8
- Fòrmula: C4H8S3
- Peso molecular:152.30
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Almacenamiento:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (170-190 g)[1]
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Dosage:50, 100 and 200 mg/kg
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Administration:orally in the daily morning for 30 days
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Result:Enhanced body, organ weight and reduced food, water intake.
Dose-dependently decreased plasma glucose and enhanced insulin.
Attenuated the oxidative stress stimulated by STZ in hepatocytes.
Increased activity of hepatotoxicity markers AST, ALT and ALP.
Significantly downregulated the expression of pro-inflammatory proteins, cytokines (TNF-α and IL-6) and transcription factors (NF-κB p65).
Chemical Information
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No. CAS 34135-85-8
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Appearance Liquid
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Peso molecular 152.30
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Fòrmula C4H8S3
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Color Colorless to light yellow
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SMILES
CSSSCC=C
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : ≥ 200 mg/mL (1313.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocolo
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.5660 mL | 32.8299 mL | 65.6599 mL | 164.1497 mL |
| 5 mM | 1.3132 mL | 6.5660 mL | 13.1320 mL | 32.8299 mL | |
| 10 mM | 0.6566 mL | 3.2830 mL | 6.5660 mL | 16.4150 mL | |
| 15 mM | 0.4377 mL | 2.1887 mL | 4.3773 mL | 10.9433 mL | |
| 20 mM | 0.3283 mL | 1.6415 mL | 3.2830 mL | 8.2075 mL | |
| 25 mM | 0.2626 mL | 1.3132 mL | 2.6264 mL | 6.5660 mL | |
| 30 mM | 0.2189 mL | 1.0943 mL | 2.1887 mL | 5.4717 mL | |
| 40 mM | 0.1641 mL | 0.8207 mL | 1.6415 mL | 4.1037 mL | |
| 50 mM | 0.1313 mL | 0.6566 mL | 1.3132 mL | 3.2830 mL | |
| 60 mM | 0.1094 mL | 0.5472 mL | 1.0943 mL | 2.7358 mL | |
| 80 mM | 0.0821 mL | 0.4104 mL | 0.8207 mL | 2.0519 mL | |
| 100 mM | 0.0657 mL | 0.3283 mL | 0.6566 mL | 1.6415 mL |
Allyl methyl trisulfide Related Classifications
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