2417155-47-4
Chemical Structure
CT-133
- CAS No.: 2417155-47-4
- Formula:C20H19FN3NaO4S
- Molecular Weight:439.44
IUPAC Name: (R)-2-(8-((4-fluoro-N-methylphenyl)sulfonamido)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetic acid, sodium salt
InChIKey: NSSNWWSMPAEYGJ-PFEQFJNWSA-M
SMILES: O=C(O[Na])CC1=C2N(C[C@@H](CC2)N(C)S(=O)(C3=CC=C(C=C3)F)=O)C4=NC=CC=C41
Biological Activity: CT-133 is a selective and potent CRTH2 Receptor antagonist, with a Ki value of 2.2 nM. The Ki value for the DP1 receptor is greater than 3800 nM. CT-133 inhibits neutrophil migration induced by PGD2 (HY-101988). CT-133 significantly alleviates lung inflammation and improves lung function impairment in a mouse model of acute lung injury (ALI) induced by cigarette smoke. CT-133 effectively inhibits the excessive expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokines (KC), and reverses the inhibition of the anti-inflammatory factor IL-10. CT-133 can be used for the study of ALI[1].
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CT-133 | CT-133 is a selective and potent CRTH2 Receptor antagonist, with a Ki value of 2.2 nM. The Ki value for the DP1 receptor is greater than 3800 nM. CT-133 inhibits neutrophil migration induced by PGD2 (HY-101988). CT-133 significantly alleviates lung inflammation and improves lung function impairment in a mouse model of acute lung injury (ALI) induced by cigarette smoke. CT-133 effectively inhibits the excessive expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokines (KC), and reverses the inhibition of the anti-inflammatory factor IL-10. CT-133 can be used for the study of ALI. | |||||||||||||||||||||
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Keywords
