300842-59-5
Chemical Structure
NVP-AAD777
- CAS No.: 300842-59-5
- Formula:C22H14F6N4
- Molecular Weight:448.36
IUPAC Name: N-(3,4-bis(trifluoromethyl)phenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
InChIKey: BSIYFOACHNHUPJ-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC=C(C=C1C(F)(F)F)NC2=NN=C(C3=C2C=CC=C3)CC4=CC=NC=C4
Biological Activity: NVP-AAD777 is a specific inhibitor of VEGFR-2, demonstrated in vivo by its effective suppression of phospho-VEGFR-2 (Tyr1175) signaling in rat lung tissues. Unlike the nonspecific VEGFR inhibitor SUG-5416, NVP-AAD777 did not induce emphysematous changes in the lungs after three weeks of treatment, even when combined with exposure to cigarette smoke. Additionally, there were no alterations observed in vascular density compared to control animals. This indicates NVP-AAD777's targeted action in inhibiting VEGFR-2 without adverse pulmonary effects, highlighting its potential therapeutic utility in managing conditions associated with aberrant VEGFR-2 signaling[1].
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NVP-AAD777 | NVP-AAD777 is a specific inhibitor of VEGFR-2, demonstrated in vivo by its effective suppression of phospho-VEGFR-2 (Tyr1175) signaling in rat lung tissues. Unlike the nonspecific VEGFR inhibitor SUG-5416, NVP-AAD777 did not induce emphysematous changes in the lungs after three weeks of treatment, even when combined with exposure to cigarette smoke. Additionally, there were no alterations observed in vascular density compared to control animals. This indicates NVP-AAD777's targeted action in inhibiting VEGFR-2 without adverse pulmonary effects, highlighting its potential therapeutic utility in managing conditions associated with aberrant VEGFR-2 signaling. | |||||||||||||||||||||
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Keywords
