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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
common gamma chain
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "common gamma chain" in MCE Product Catalog:
9
9 Publications Verification
Synonyms: PF-06651600
Target:
Research Areas:
Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
9
9 Publications Verification
Synonyms: PF-06651600 tosylate
Target:
Research Areas:
Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
Cat. No.: HY-P99410
CAS No.: 879293-15-9
Synonyms: AMG 714; PRV-015
Target:
Research Areas:
Cat. No.: HY-P991201
Target:
Research Areas:
Cat. No.: HY-P990292
Target:
Research Areas:
Cat. No.: HY-100754A
CAS No.: 2140301-97-7
Synonyms: PF-06651600 malonate
Target:
Research Areas:
Ritlecitinib (PF-06651600) malonate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib malonate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib malonate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
Cat. No.: HY-174622
Target:
Research Areas:
Human IL21 mRNA encodes the human interleukin 21 (IL21) protein, a member of the common-gamma chain family of cytokines. IL21 plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells.
Cat. No.: HY-P74805
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Cat. No.: HY-P74806
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Cat. No.: HY-P74807
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Cat. No.: HY-P70556
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Cat. No.: HY-P70693
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Cat. No.: HY-P77591
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Species:
Source:
Cat. No.: HY-P700858
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Cat. No.: HY-P78083
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Cat. No.: HY-P78401
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Cat. No.: HY-P705045
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Species:
Source:
Cat. No.: HY-P705160
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL2RG; IL-2 Receptor Subunit gamma; Prev. SCIDX1; CD132 Antigen; Prev. CIDX; IL-2RG; Prev. IMD4; common Cytokine Receptor gamma chain; Cytokine Receptor common Subunit gamma; Combined Immunodeficiency, X-Linked; gammaC; Severe Combined Immunodeficiency; C
Cat. No.: HY-100754R
CAS No.: 1792180-81-4
Synonyms: PF-06651600 (Standard)
Research Areas:
Ritlecitinib (Standard) is the analytical standard of Ritlecitinib (HY-100754). This product is intended for research and analytical applications. Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
