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Results for "

cul4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Apoptosis (3) Autophagy (3) Casein Kinase (1) CDK (2) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (3) Epigenetic Reader Domain (7) HIV (2) Integrin (1) Ligands for E3 Ligase (4) Molecular Glues (9) PROTACs (3) Reference Standards (1) Small Interfering RNA (siRNA) (6) SWI/SNF Complex (1) WDR5 (1)
By Research Areas:	Cancer (19) Infection (3) Inflammation/Immunology (3) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14658

Thalidomide Maximum Cited Publications 25 Publications Verification	Ligands for E3 Ligase Autophagy Apoptosis Molecular Glues	Inflammation/Immunology Cancer
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K_d of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.

HY-14571

E7820 5 Publications Verification ER68203-00	Molecular Glues Integrin	Infection Metabolic Disease Cancer
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 ^DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC₅₀ of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .

HY-156828

MMH2	Molecular Glues Epigenetic Reader Domain	Cancer
MMH2 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4_BD2) .

HY-156827

MMH1	Molecular Glues Epigenetic Reader Domain	Cancer
MMH1 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4_BD2) .

HY-170859

AH078	PROTACs Casein Kinase	Cancer
AH078 is a PROTAC-based CK1δ/ε degrader (DC₅₀=0.55 μM, D_max=70%) that lacks subtype selectivity between CK1δ and CK1ε. AH078 induces target protein degradation either by recruiting the CUL4-CRBN E3 ligase complex and proteasome, or via the VHL- and ubiquitin-dependent pathway. AH078 also exhibits selectivity for CK1α, and is widely applicable to research related to colon cancer, pancreatic cancer, breast cancer, ovarian cancer, chronic lymphocytic leukemia, acute myeloid leukemia, glioma, and metastatic breast adenocarcinoma .

HY-14658R

Thalidomide (Standard)	Ligands for E3 Ligase Autophagy Apoptosis Reference Standards	Inflammation/Immunology Cancer
Thalidomide (Standard) is the analytical standard of Thalidomide. This product is intended for research and analytical applications. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K_d of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.

HY-175756

SMARCA2/4 degrader-1	Molecular Glues SWI/SNF Complex	Cancer
SMARCA2/4 degrader-1 is a *SMARCA2/4* molecular glue degrader with a DCAF16 EC₅₀ of 110 nM. SMARCA2/4 degrader-1 covalently adducts at cysteine to form a ternary complex with SMARCA2/4 and recruits CUL4 ^DCAF16 and CRL1 ^FBXO22 E3 ligase complexes. SMARCA2/4 degrader-1 induces ubiquitination and proteasomal degradation of SMARCA2/4. SMARCA2/4 degrader-1 can be used for research of SMARCA4-deficient malignancies, non-small cell lung cancer (NSCLC), and colorectal cancer .

HY-161166

MM-02-57	Others	Others
MM-02-57 is a covalent DDB1 CUL4A adaptor protein recruiter .

HY-148602

KH-4-43 1 Publications Verification	E1/E2/E3 Enzyme	Cancer
KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-4-43 has a binding K_d to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively .

HY-14658S

Thalidomide-d4	Molecular Glues Ligands for E3 Ligase Autophagy Apoptosis	Inflammation/Immunology Cancer
Thalidomide-d₄ is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties .

HY-175187

LO-3-63	CDK E1/E2/E3 Enzyme	Cancer
LO-3-63, a Ribociclib (HY-15777) analog bearing a truncated fumaramide handle, is a PROTAC-like *CDK4/6* degrader. LO-3-63 induces CUL4 ^DCAF16-dependent degradation of *CDK4/6* in cells .

HY-150184

And1-IN-1	DNA/RNA Synthesis	Cancer
And1-IN-1 is a potent And1 inhibitor with an IC₅₀ of 2.08 μM. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer .

HY-176070

HRG038	Epigenetic Reader Domain	Cancer
HRG038 is a selective covalent *BRD4* degrader. HRG038 binds covalently to the E3 ubiquitin ligase CUL4 DCAF16, recruiting it to BRD4, leading to the ubiquitination and subsequent proteasomal degradation of BRD4. HRG038 is promising for research of cancers .

HY-157592

MMH2-NR	Molecular Glues Epigenetic Reader Domain	Cancer
MMH2-NR a negtive control of MMH2. MMH2 is a CUL4-associated factor (DCAF16)-based bromodomain protein 4 (BRD4) degrader .

HY-173274

CB039	Molecular Glues	Cancer
CB039 is a selective a molecular glue degrader that targets RBM39 (RNA-binding protein 39). CB039 promotes the formation of a ternary complex between RBM39 and the E3 ubiquitin ligase CUL4-DCAF15, leading to proteasomal degradation of RBM39. CB039 is promising for research of cancers with RBM39 dependency, such as acute myeloid leukemia (AML) and ovarian cancer .

HY-176067

LO-4-25	Androgen Receptor	Cancer
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its truncated variant AR-V7. LO-4-25 covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, promoting the ubiquitination of AR and AR-V7, which subsequently are recognized and degraded by the proteasome, reducing the protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research of androgen-independent prostate cancers .

HY-157591

MMH1-NR	Molecular Glues Epigenetic Reader Domain	Cancer
MMH1-NR, containing a non-reactive (ethyl) group is a negative control of MMH1. MMH1 is a CUL4-associated factor (DCAF16)-based bromodomain protein 4 (BRD4) degrader .

HY-P11028

M1-20	CDK	Cancer
M1-20 is a CDK1 inhibitor. M1-20 promotes CDK1 ubiquitination by CUL4-DDB1-DCAF1 complexes and degradation through the proteasome pathway. M1-20 abolishes the formation of CDK1/CCNB1 complexes. M1-20 has significant anticancer activity of spontaneous breast cancer in FVB/N MMTV-PyVT mice model .

HY-175179

LO-3-61	Epigenetic Reader Domain E1/E2/E3 Enzyme	Cancer
LO-3-61, a JQ-1 (HY-13030) analog bearing a truncated fumaramide handle, is a PROTAC (proteolysis-targeting chimeras)-like *BRD4* degrader. LO-3-61 degrades both the long and short isoforms of *BRD4* CUL4DcAr16-dependently in cells. LO-3-61 shows selectivity for BRD3 and *BRD4* degradation in MDA-MB-231 cells .

HY-RS28983

Cul4a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cul4a Rat Pre-designed siRNA Set A contains three designed siRNAs for Cul4a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cul4a Rat Pre-designed siRNA Set A Cul4a Rat Pre-designed siRNA Set A

HY-RS03362

CUL4A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CUL4A Human Pre-designed siRNA Set A contains three designed siRNAs for CUL4A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CUL4A Human Pre-designed siRNA Set A CUL4A Human Pre-designed siRNA Set A

HY-RS03363

CUL4B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CUL4B Human Pre-designed siRNA Set A contains three designed siRNAs for CUL4B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CUL4B Human Pre-designed siRNA Set A CUL4B Human Pre-designed siRNA Set A

HY-RS28984

Cul4b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cul4b Rat Pre-designed siRNA Set A contains three designed siRNAs for Cul4b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cul4b Rat Pre-designed siRNA Set A Cul4b Rat Pre-designed siRNA Set A

HY-169389

OICR41114	PROTACs WDR5	Cancer
OICR41114 is a WDR5 PROTAC degrader with an EC₅₀ of 40 nM. OICR41114 binds both DCAF1 and WDR5, and its binding affinity for DCAF1 is significantly enhanced in the presence of WDR5 (K_D increases from 59 nM to 5 nM). OICR41114 exerts antiproliferative effects on MV4-11 cells. OICR41114 can be used for the research of acute myeloid leukemia .

HY-RS22460

Cul4a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cul4a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cul4a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cul4a Mouse Pre-designed siRNA Set A Cul4a Mouse Pre-designed siRNA Set A

HY-RS22461

Cul4b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cul4b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cul4b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cul4b Mouse Pre-designed siRNA Set A Cul4b Mouse Pre-designed siRNA Set A

HY-181164

PROTAC BRD4 Degrader-43	PROTACs Epigenetic Reader Domain HIV	Infection
PROTAC BRD4 Degrader-43 is a BRD4 PROTAC degrader. PROTAC BRD4 Degrader-43 recruits the DCAF1-DDB1-Cul4A E3 ligase complex via a Vpr-derived peptide moiety to induce BRD4 ubiquitination and degradation through the ubiquitin-proteasome system. PROTAC BRD4 Degrader-43 exhibits potent HIV latency-reversing activity. PROTAC BRD4 Degrader-43 can be used for the research of HIV-1 latent infection . (Pink: BRD4 ligand (HY-13030); Blue: Cul4A-DDB1-DCAF1 ligand (HY-P11640); Black: conjugate of PEG linker + cell-penetrating peptide (HY-P2483))

HY-P11640

Vpr (1-14)	Ligands for E3 Ligase HIV	Infection
Vpr (1-14) is a viral protein R and acts as an accessory protein of HIV-1. Vpr (1-14) can binds to Cul4A-DDB1-DCAF1 E3 ligase complex and can be used as an E3 ligase-binding component in PROTACs. Vpr (1-14) can be used to synthesize PROTAC BRD4 Degrader-43 (HY-181164) .

Cat. No.	Product Name	Target	Research Area

HY-P11028

M1-20	CDK	Cancer
M1-20 is a CDK1 inhibitor. M1-20 promotes CDK1 ubiquitination by CUL4-DDB1-DCAF1 complexes and degradation through the proteasome pathway. M1-20 abolishes the formation of CDK1/CCNB1 complexes. M1-20 has significant anticancer activity of spontaneous breast cancer in FVB/N MMTV-PyVT mice model .

HY-P11640

Vpr (1-14)	Ligands for E3 Ligase HIV	Infection
Vpr (1-14) is a viral protein R and acts as an accessory protein of HIV-1. Vpr (1-14) can binds to Cul4A-DDB1-DCAF1 E3 ligase complex and can be used as an E3 ligase-binding component in PROTACs. Vpr (1-14) can be used to synthesize PROTAC BRD4 Degrader-43 (HY-181164) .

Species:	Human (9)
Tag:	His (4) Strep (1) Tag Free (5) Avi (1) Flag (1)
Source:	HEK293 (1) Sf9 insect cells (8)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703246

	CUL4A-RBX1 Protein, Human (Active, sf9) cullin-4A; cul4A; Homo sapiens; Human	Human	Sf9 insect cells

HY-P702817

	*CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (HEK293, Flag, His)* Cereblon-DDB1-cul4A-Rbx1 Complex	Human	HEK293
	CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (HEK293, Flag, His) is the recombinant human-derived Cereblon, expressed by HEK293 , with N-6*His, N-Flag labeled tag.

HY-P702826

	*CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (sf9, His, Avi)* Cereblon-DDB1-cul4A-Rbx1 Complex	Human	Sf9 insect cells
	CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (sf9, His, Avi) is the recombinant human-derived CRBN-DDB1-CUL4A-RBX1 Complex, expressed by Sf9 insect cells , with N-His, N-Avi labeled tag. ,

HY-P703559

	*DCAF16-DDB1-CUL4A-RBX1 Protein, Human (sf9)* C4orf30	Human	Sf9 insect cells
	DCAF16 Protein, a vital component in the CUL4-DDB1 E3 ubiquitin-protein ligase complex, serves as a crucial substrate recognition element. It plays a central role in ubiquitination and subsequent proteasome-dependent degradation of nuclear proteins, emphasizing its key involvement in protein modification processes, particularly in the regulation of protein ubiquitination. DCAF16/DDB1/CUL4A/RBX1 Protein, Human (Sf9) is the recombinant human-derived DCAF16/DDB1/CUL4A/RBX1, expressed by Sf9 insect cells, with tag-free.

HY-P701517

	DCAF16 Protein, Human (sf9) DCAF16; DDB1- and cul4-associated factor 16	Human	Sf9 insect cells
	DCAF16 Protein, a vital component in the CUL4-DDB1 E3 ubiquitin-protein ligase complex, serves as a crucial substrate recognition element. It plays a central role in ubiquitination and subsequent proteasome-dependent degradation of nuclear proteins, emphasizing its key involvement in protein modification processes, particularly in the regulation of protein ubiquitination. DCAF16 Protein, Human (sf9) is the recombinant human-derived DCAF16 protein, expressed by sf9 insect cells , with tag free.

HY-P701518

	DCAF16 Protein, Human (sf9, His) DCAF16; DDB1- and cul4-associated factor 16	Human	Sf9 insect cells
	DCAF16 Protein, a vital component in the CUL4-DDB1 E3 ubiquitin-protein ligase complex, serves as a crucial substrate recognition element. It plays a central role in ubiquitination and subsequent proteasome-dependent degradation of nuclear proteins, emphasizing its key involvement in protein modification processes, particularly in the regulation of protein ubiquitination. DCAF16 Protein, Human (sf9, His) is the recombinant human-derived DCAF16 protein, expressed by sf9 insect cells , with N-6*His labeled tag.

HY-P701519

	DCAF15-DDB1 Protein, Human (sf9) DCAF15-DDB1 complex; DCAF15; DDB1- and cul4-associated factor 15	Human	Sf9 insect cells
	DCAF15 serves as a substrate recognition component in the DCX (DCAF15) complex, coordinating the ubiquitination and degradation of target proteins and may affect NK cell function and APC-NK cell interactions. Notably, arylsulfonamide anticancer drugs alter the substrate specificity of the complex, promoting ubiquitination and degradation of RBM39, RBM23, and PRPF39. DCAF15-DDB1 Protein, Human (sf9) is the recombinant human-derived DCAF15 protein, expressed by sf9 insect cells , with tag free.

HY-P701520

	DCAF15-DDB1 Protein, Human (Active, sf9, His, StrepⅡ) DCAF15-DDB1 complex; DCAF15; DDB1- and cul4-associated factor 15	Human	Sf9 insect cells
	DCAF15 serves as a substrate recognition component in the DCX (DCAF15) complex, coordinating the ubiquitination and degradation of target proteins and may affect NK cell function and APC-NK cell interactions. Notably, arylsulfonamide anticancer drugs alter the substrate specificity of the complex, promoting ubiquitination and degradation of RBM39, RBM23, and PRPF39. DCAF15-DDB1 Protein, Human (sf9, His, Strep) is the recombinant human-derived DCAF15-DDB1 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701521

	DCAF7 Protein, Human (sf9) DCAF7; DDB1- and cul4-associated factor 7; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog	Human	Sf9 insect cells
	The DCAF7 protein occupies a central position in craniofacial development and is critical for the EDN1 pathway and maxillary formation. Its nuanced involvement suggests different requirements for EDN1 function in the first and second arches. DCAF7 Protein, Human (sf9) is the recombinant human-derived DCAF7 protein, expressed by sf9 insect cells , with tag free.

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Thalidomide-d4
Thalidomide-d₄ is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties .

Host:	Rabbit (5)
Reactivity:	Human (5) Rat (4) Mouse (2) Hamster (2)
Application:	IHC-P (5) ICC/IF (1) IF-Tissue (1) IP (2) IHC-F (1) WB (5) FC (1)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (4)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86844

	DCAF13 Antibody (YA6537) DCA13_HUMAN antibody; DCAF13 antibody; DDB1 and cul4 associated factor 13 antibody; DDB1- and cul4-associated factor 13 antibody; DKFZP564O0463 antibody; GM83 antibody; HSPC064 antibody; MGC126859 antibody; MGC138247 antibody; WD repeat and SOF domain-containing protein 1 antibody; DCA13_HUMAN antibody; DCAF13 antibody; DDB1 and cul4 associated factor 13 antibody; DDB1- and cul4-associated factor 13 antibody; DKFZP564O0463 antibody; GM83 antibody; HSPC064 antibody; MGC126859 antibody; MGC138247 antibody; WD repeat and SOF domain-containing protein 1 antibody; WD repeats and SOF1 domain containing antibody; WDSOF1 antibody;	WB, IHC-P, IP	Human, Mouse, Rat
	DCAF13 Antibody (YA6537) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DCAF13.

HY-P86842

	Cullin 4a Antibody (YA6535) 2810470J21Rik antibody; AW495282 antibody; cul 4A antibody; cul-4A antibody; cul4a antibody; cul4a protein antibody; cul4A_HUMAN antibody; cullin-4A antibody; MGC36573 antibody; MGC64071 antibody;	WB, IHC-P, IHC-F, IF-Tissue, FC, ICC/IF, IP	Human
	Cullin 4a Antibody (YA6535) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cullin 4a.

HY-P82838

	Cullin 4A/4B Antibody (YA2583) cul4B; KIAA0695; cullin-4B; cul-4B	WB, IHC-P	Human, Hamster, Rat
	Cullin 4A/4B Antibody (YA2583) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cullin 4A/4B.

HY-P82838A

	Cullin 4A/4B Antibody (YA2583)(PBS only) cul4B; KIAA0695; cullin-4B; cul-4B	WB, IHC-P	Human, Hamster, Rat
	Cullin 4A/4B Antibody (YA2583) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cullin 4A/4B.

HY-P87301

	WDR68 Antibody (YA6984) AN11 antibody; Dcaf7 antibody; DCAF7_HUMAN antibody; DDB1- and cul4-associated factor 7 antibody; HAN11 antibody; Human anthocyanin antibody; Petunia antibody; Seven WD repeat protein of the AN11 family 1 antibody; SWAN 1 antibody; WD repeat domain 68 antibody	WB, IHC-P	Human, Mouse, Rat
	WDR68 Antibody (YA6984) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WDR68.

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